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Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?
Ling KM, Stick SM, Kicic A. Ling KM, et al. Among authors: stick sm. Front Med (Lausanne). 2023 May 17;10:1088494. doi: 10.3389/fmed.2023.1088494. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37265479 Free PMC article. Review.
Early treatment with antibiotics limits the prevalence of bacterial pathogens but permanently alters the CF airway microenvironment, resulting in antibiotic resistance and other long-term consequences. With little investment into new traditional antibiotics, safe and effec …
Early treatment with antibiotics limits the prevalence of bacterial pathogens but permanently alters the CF airway microenvironment, resulti …
Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease.
Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R. Margaroli C, et al. Among authors: stick sm. J Cyst Fibros. 2022 Nov;21(6):967-976. doi: 10.1016/j.jcf.2022.06.001. Epub 2022 Jun 19. J Cyst Fibros. 2022. PMID: 35732550 Free article.
In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior to chronic infection, suggesting a potential defect in macrophage immunomodulatory function. ...In an in vitro model mimicking leukocyte rec …
In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior …
Changes in airway inflammation with pseudomonas eradication in early cystic fibrosis.
Garratt LW, Breuer O, Schofield CJ, McLean SA, Laucirica DR, Tirouvanziam R, Clements BS, Kicic A, Ranganathan S, Stick SM, Cf OBOA. Garratt LW, et al. Among authors: stick sm. J Cyst Fibros. 2021 Nov;20(6):941-948. doi: 10.1016/j.jcf.2020.12.015. Epub 2021 Jan 15. J Cyst Fibros. 2021. PMID: 33461938 Free article.
Evaluating strategies to diminish neutrophilic inflammation is essential for improving long-term outcomes....
Evaluating strategies to diminish neutrophilic inflammation is essential for improving long-term outcomes....
Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus.
De Jong E, Garratt LW, Looi K, Lee AHY, Ling KM, Smith ML, Falsafi R, Sutanto EN, Hillas J, Iosifidis T, Martinovich KM, Shaw NC, Montgomery ST, Kicic-Starcevich E, Lannigan FJ, Vijayasekaran S, Hancock REW, Stick SM, Kicic A; WAERP; Arest CF. De Jong E, et al. Among authors: stick sm. J Cyst Fibros. 2021 Jan;20(1):97-105. doi: 10.1016/j.jcf.2020.07.004. Epub 2020 Jul 17. J Cyst Fibros. 2021. PMID: 32684439 Free article.
In addition, CFTR modulators did not affect viral copy number, or levels of pro-inflammatory cytokines produced post-infection. CONCLUSIONS: Though long-term clinical data is not yet available, results presented here suggest that first generation CFTR modulators do not int …
In addition, CFTR modulators did not affect viral copy number, or levels of pro-inflammatory cytokines produced post-infection. CONCLUSIONS: …
BAL Inflammatory Markers Can Predict Pulmonary Exacerbations in Children With Cystic Fibrosis.
Ishak A, Stick SM, Turkovic L, Ranganathan SC, King L, Harrison J, Sly PD, Caudri D, Schultz A; AREST CF. Ishak A, et al. Among authors: stick sm. Chest. 2020 Dec;158(6):2314-2322. doi: 10.1016/j.chest.2020.06.044. Epub 2020 Jul 3. Chest. 2020. PMID: 32622821
Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. RESEARCH QUESTION: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obta …
Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbi …
Structural determinants of long-term functional outcomes in young children with cystic fibrosis.
Turkovic L, Caudri D, Rosenow T, Breuer O, Murray C, Tiddens HAWM, Ramanauskas F, Ranganathan SC, Hall GL, Stick SM; AREST CF. Turkovic L, et al. Among authors: stick sm. Eur Respir J. 2020 May 21;55(5):1900748. doi: 10.1183/13993003.00748-2019. Print 2020 May. Eur Respir J. 2020. PMID: 32139454 Free article.
DISCUSSION: Chest CT identifies children at an early age who have adverse long-term outcomes. The prevention of structural lung damage should be a goal of early intervention and can be usefully assessed with chest CT. In an era of therapeutics that might alter disease traj …
DISCUSSION: Chest CT identifies children at an early age who have adverse long-term outcomes. The prevention of structural lung damag …
The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis.
Rosenow T, Mok LC, Turkovic L, Berry LJ, Sly PD, Ranganathan S, Tiddens HAWM, Stick SM. Rosenow T, et al. Among authors: stick sm. Eur Respir J. 2019 Jul 11;54(1):1801771. doi: 10.1183/13993003.01771-2018. Print 2019 Jul. Eur Respir J. 2019. PMID: 31023850 Free article.
However, whether in young children they are transient findings or have cumulative, long-term impacts on respiratory health is largely unknown. We aimed to determine whether their repeated detection has a deleterious effect on structural lung disease. ...
However, whether in young children they are transient findings or have cumulative, long-term impacts on respiratory health is largely …
Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients.
Ling KM, Hillas J, Lavender MA, Wrobel JP, Musk M, Stick SM, Kicic A. Ling KM, et al. Among authors: stick sm. Respirology. 2019 Dec;24(12):1212-1219. doi: 10.1111/resp.13550. Epub 2019 Apr 15. Respirology. 2019. PMID: 30989728
BACKGROUND AND OBJECTIVE: Human rhinovirus (RV) is a common upper and lower respiratory pathogen in lung allograft recipients causing respiratory tract exacerbation and contributing towards allograft dysfunction and long-term lung decline. In this study, we tested the hypo …
BACKGROUND AND OBJECTIVE: Human rhinovirus (RV) is a common upper and lower respiratory pathogen in lung allograft recipients causing respir …
Early Lung Disease in Infants and Preschool Children with Cystic Fibrosis. What Have We Learned and What Should We Do about It?
Ranganathan SC, Hall GL, Sly PD, Stick SM, Douglas TA; Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF). Ranganathan SC, et al. Among authors: stick sm. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1567-1575. doi: 10.1164/rccm.201606-1107CI. Am J Respir Crit Care Med. 2017. PMID: 27911585 Free PMC article. Review.
Early childhood represents a pivotal period amenable to intervention strategies that could delay or prevent the onset of lung damage and alter the longer-term clinical trajectory for individuals with CF. This review summarizes what we have learned about early lung disease …
Early childhood represents a pivotal period amenable to intervention strategies that could delay or prevent the onset of lung damage and alt …
Respiratory function and symptoms in young preterm children in the contemporary era.
Verheggen M, Wilson AC, Pillow JJ, Stick SM, Hall GL. Verheggen M, et al. Among authors: stick sm. Pediatr Pulmonol. 2016 Dec;51(12):1347-1355. doi: 10.1002/ppul.23487. Epub 2016 May 26. Pediatr Pulmonol. 2016. PMID: 27228468
METHODS: Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non-BPD, and healthy term controls were studied. Lung function was measured by forced oscillation technique (respiratory resistance [Rrs] and reactance [Xrs]) and spirometry. …
METHODS: Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non-BPD, and healthy term controls …
17 results