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The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3-induced cell cycle arrest.
Solorzano-Vargas RS, Bjerknes M, Wu SV, Wang J, Stelzner M, Dunn JCY, Dhawan S, Cheng H, Georgia S, Martín MG. Solorzano-Vargas RS, et al. Among authors: stelzner m. J Biol Chem. 2019 Oct 11;294(41):15182-15192. doi: 10.1074/jbc.RA119.008926. Epub 2019 Jul 24. J Biol Chem. 2019. PMID: 31341016 Free PMC article.
In endocrine lineage cells, the cellular quiescence induced by short-term NEUROG3 expression required cyclin-dependent kinase inhibitor 1A (CDKN1A)/p21(CIP1) expression. ...
In endocrine lineage cells, the cellular quiescence induced by short-term NEUROG3 expression required cyclin-dependent kinase inhibit …
Long-term renewable human intestinal epithelial stem cells as monolayers: A potential for clinical use.
Scott A, Rouch JD, Jabaji Z, Khalil HA, Solorzano S, Lewis M, Martín MG, Stelzner MG, Dunn JC. Scott A, et al. Among authors: stelzner mg. J Pediatr Surg. 2016 Jun;51(6):995-1000. doi: 10.1016/j.jpedsurg.2016.02.074. Epub 2016 Mar 2. J Pediatr Surg. 2016. PMID: 26995514 Free PMC article.
RESULTS: Intestinal epithelial monolayers were capable of long-term cell renewal. Less differentiated monolayers expressed high levels of gene marker LGR5, while more differentiated monolayers had higher expressions of CDX2, MUC2, LYZ, DEF5, and CHGA. ...
RESULTS: Intestinal epithelial monolayers were capable of long-term cell renewal. Less differentiated monolayers expressed high level …
A novel culture system for adult porcine intestinal crypts.
Khalil HA, Lei NY, Brinkley G, Scott A, Wang J, Kar UK, Jabaji ZB, Lewis M, Martín MG, Dunn JC, Stelzner MG. Khalil HA, et al. Among authors: stelzner mg. Cell Tissue Res. 2016 Jul;365(1):123-34. doi: 10.1007/s00441-016-2367-0. Epub 2016 Mar 1. Cell Tissue Res. 2016. PMID: 26928041 Free PMC article.
Thus, our method maintains juvenile and adult porcine crypt cells long-term in culture. Porcine enteroids and spheroids can be successfully passaged and transduced by using lentiviral vectors....
Thus, our method maintains juvenile and adult porcine crypt cells long-term in culture. Porcine enteroids and spheroids can be succes …
Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids.
Rouch JD, Scott A, Lei NY, Solorzano-Vargas RS, Wang J, Hanson EM, Kobayashi M, Lewis M, Stelzner MG, Dunn JC, Eckmann L, Martín MG. Rouch JD, et al. Among authors: stelzner mg. PLoS One. 2016 Jan 28;11(1):e0148216. doi: 10.1371/journal.pone.0148216. eCollection 2016. PLoS One. 2016. PMID: 26820624 Free PMC article.
Typhimurium. RESULTS: Functional M cells were generated by short-term culture of freshly isolated human intestinal crypts in a dose- and time-dependent fashion. ...
Typhimurium. RESULTS: Functional M cells were generated by short-term culture of freshly isolated human intestinal crypts in a dose- …
Primary Myofibroblasts Maintain Short-Term Viability following Submucosal Injection in Syngeneic, Immune-Competent Mice Utilizing Murine Colonoscopy.
Khalil HA, Lei NY, Nie W, Lewis MS, Stelzner MG, Martín MG, Dunn JC, Yoo J. Khalil HA, et al. Among authors: stelzner mg. PLoS One. 2015 May 27;10(5):e0127258. doi: 10.1371/journal.pone.0127258. eCollection 2015. PLoS One. 2015. PMID: 26016485 Free PMC article.
Myofibroblasts injected either into the submucosa or lamina propria maintained viability on post-injection day 7 as evidenced by positive alpha-SMA staining. qPCR of lamina propria injections showed a dose-dependent increase in GFP DNA transcripts on post-injection day 1, whereas …
Myofibroblasts injected either into the submucosa or lamina propria maintained viability on post-injection day 7 as evidenced by positive al …
Type I collagen as an extracellular matrix for the in vitro growth of human small intestinal epithelium.
Jabaji Z, Brinkley GJ, Khalil HA, Sears CM, Lei NY, Lewis M, Stelzner M, Martín MG, Dunn JC. Jabaji Z, et al. Among authors: stelzner m. PLoS One. 2014 Sep 15;9(9):e107814. doi: 10.1371/journal.pone.0107814. eCollection 2014. PLoS One. 2014. PMID: 25222024 Free PMC article.
These markers were maintained through several passages. CONCLUSION: Type I collagen gel supports long-term in vitro maintenance and expansion of fully elaborated human intestinal epithelium. ...
These markers were maintained through several passages. CONCLUSION: Type I collagen gel supports long-term in vitro maintenance and e …
Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells.
Lei NY, Jabaji Z, Wang J, Joshi VS, Brinkley GJ, Khalil H, Wang F, Jaroszewicz A, Pellegrini M, Li L, Lewis M, Stelzner M, Dunn JC, Martín MG. Lei NY, et al. Among authors: stelzner m. PLoS One. 2014 Jan 6;9(1):e84651. doi: 10.1371/journal.pone.0084651. eCollection 2014. PLoS One. 2014. PMID: 24400106 Free PMC article.
Co-culture of ISCs with supportive ISEMFs relinquished the requirement of exogenous R-spondin1 to sustain long-term growth and differentiation of ISCs. Mono- and co-cultures were implanted subcutaneously in syngeneic mice. ...
Co-culture of ISCs with supportive ISEMFs relinquished the requirement of exogenous R-spondin1 to sustain long-term growth and differ …
Use of collagen gel as an alternative extracellular matrix for the in vitro and in vivo growth of murine small intestinal epithelium.
Jabaji Z, Sears CM, Brinkley GJ, Lei NY, Joshi VS, Wang J, Lewis M, Stelzner M, Martín MG, Dunn JC. Jabaji Z, et al. Among authors: stelzner m. Tissue Eng Part C Methods. 2013 Dec;19(12):961-9. doi: 10.1089/ten.TEC.2012.0710. Epub 2013 May 10. Tissue Eng Part C Methods. 2013. PMID: 23566043 Free PMC article.
We demonstrate for the first time the capacity to support the long-term in vitro growth of murine intestinal epithelium in monoculture, using type I collagen. ...
We demonstrate for the first time the capacity to support the long-term in vitro growth of murine intestinal epithelium in monocultur …
A nomenclature for intestinal in vitro cultures.
Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J; NIH Intestinal Stem Cell Consortium. Stelzner M, et al. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1359-63. doi: 10.1152/ajpgi.00493.2011. Epub 2012 Mar 29. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22461030 Free PMC article. Review.
Many advances have been reported in the long-term culture of intestinal mucosal cells in recent years. A significant number of publications have described new culture media, cell formations, and growth patterns. ...
Many advances have been reported in the long-term culture of intestinal mucosal cells in recent years. A significant number of public …
Clinical features and treatment outcome of intussusception in premature neonates.
Avansino JR, Bjerke S, Hendrickson M, Stelzner M, Sawin R. Avansino JR, et al. Among authors: stelzner m. J Pediatr Surg. 2003 Dec;38(12):1818-21. doi: 10.1016/j.jpedsurg.2003.08.048. J Pediatr Surg. 2003. PMID: 14666476
BACKGROUND/PURPOSE: Less than 1.3% of all cases of intussusception occur in term neonates. Intussusception in premature neonates (IPN) is exceedingly rare. ...RESULTS: The 35 patients with IPN had an average gestational age, postconceptual age at diagnosis, and birth …
BACKGROUND/PURPOSE: Less than 1.3% of all cases of intussusception occur in term neonates. Intussusception in premature neonates (IPN …
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