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The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA.
Jenke AC, Eisenberger T, Baiker A, Stehle IM, Wirth S, Lipps HJ. Jenke AC, et al. Among authors: stehle im. Hum Gene Ther. 2005 Apr;16(4):533-9. doi: 10.1089/hum.2005.16.533. Hum Gene Ther. 2005. PMID: 15871685
These results demonstrate that the vector system pEPI-1 allows specific and efficient long term gene suppression by using a short hairpin RNA transcription unit....
These results demonstrate that the vector system pEPI-1 allows specific and efficient long term gene suppression by using a short hai …
Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation.
Jenke AC, Scinteie MF, Stehle IM, Lipps HJ. Jenke AC, et al. Among authors: stehle im. Mol Biol Rep. 2004 Jun;31(2):85-90. doi: 10.1023/b:mole.0000031363.35839.46. Mol Biol Rep. 2004. PMID: 15293783
The ideal vector has to be free of these side effects and should allow long-term expression of a transgene in the absence of selection. In this report we describe a novel non-viral episomal expression system fulfilling these criteria. ...Moreover, we provide the first expe …
The ideal vector has to be free of these side effects and should allow long-term expression of a transgene in the absence of selectio …