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Long- and short-term effects of fecal microbiota transplantation on antibiotic resistance genes: results from a randomized placebo-controlled trial.
Rashidi A, Ebadi M, Rehman TU, Elhusseini H, Kazadi D, Halaweish H, Khan MH, Hoeschen A, Cao Q, Luo X, Kabage AJ, Lopez S, Holtan SG, Weisdorf DJ, Liu C, Ishii S, Khoruts A, Staley C. Rashidi A, et al. Among authors: staley c. Gut Microbes. 2024 Jan-Dec;16(1):2327442. doi: 10.1080/19490976.2024.2327442. Epub 2024 Mar 13. Gut Microbes. 2024. PMID: 38478462 Free PMC article. Clinical Trial.
Samples from each patient spanned a period of up to 9 months, allowing us to describe both short- and long-term effects of FMT on ARGs, while the randomized design allowed us to distinguish between spontaneous changes vs. ...The clinical implications of these findings are …
Samples from each patient spanned a period of up to 9 months, allowing us to describe both short- and long-term effects of FMT on ARG …
Validation of the AJCC 8th Edition Staging System for Disseminated Appendiceal Cancer Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Multi-institutional Analysis.
SenthilKumar G, Kothari AN, Maduekwe UN, Fournier K, Abbott DE, Wilson GC, Patel SH, Greer J, Johnston F, Dineen SP, Powers BD, Baumgartner J, Veerapong J, Leiting J, Grotz TE, Maithel SK, Staley C, Raoof M, Lambert L, Lee A, Kim A, Cloyd JM, Mogal H. SenthilKumar G, et al. Among authors: staley c. Ann Surg Oncol. 2023 Sep;30(9):5743-5753. doi: 10.1245/s10434-023-13697-9. Epub 2023 Jun 9. Ann Surg Oncol. 2023. PMID: 37294386
This study was designed to externally validate the staging system and to identify predictors of long-term survival. METHODS: A 12-institution cohort of dAC patients treated with CRS HIPEC was retrospectively analyzed. ...Separation of stage IVA patients based on the presen …
This study was designed to externally validate the staging system and to identify predictors of long-term survival. METHODS: A 12-ins …
Recovery of Patient-reported Quality of Life After Esophagectomy.
Bonanno A, Dixon M, Binongo J, Force SD, Sancheti MS, Pickens A, Kooby DA, Staley CA, Russell MC, Cardona K, Shah MM, Gillespie TW, Fernandez F, Khullar O. Bonanno A, et al. Among authors: staley ca. Ann Thorac Surg. 2023 Apr;115(4):854-861. doi: 10.1016/j.athoracsur.2022.12.015. Epub 2022 Dec 14. Ann Thorac Surg. 2023. PMID: 36526007
These findings are of considerable importance when counseling patients regarding esophagectomy, tracking recovery, and implementing quality improvement initiatives. Further long-term follow-up is needed to determine recovery beyond 100 days....
These findings are of considerable importance when counseling patients regarding esophagectomy, tracking recovery, and implementing quality …
Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens.
Block KE, Iijima K, Pierson MJ, Walsh DA, Tei R, Kucaba TA, Xu J, Khan MH, Staley C, Griffith TS, McSorley HJ, Kita H, Jameson SC. Block KE, et al. Among authors: staley c. Nat Immunol. 2022 Dec;23(12):1703-1713. doi: 10.1038/s41590-022-01350-8. Epub 2022 Nov 21. Nat Immunol. 2022. PMID: 36411381 Free PMC article.
These findings suggest that ILC2s respond dynamically to environmental cues and that microbial exposures do not control long-term desensitization of innate type 2 responses to allergens....
These findings suggest that ILC2s respond dynamically to environmental cues and that microbial exposures do not control long-term des …
Opioid Prescribing Behavior in the Emergency Department During Routine Orthopedic Manipulations.
Medline A, Wham R, Kim G, Staley C, Steck A, Boissonneault A, Schenker ML. Medline A, et al. Among authors: staley c. Am Surg. 2023 Jun;89(6):2376-2382. doi: 10.1177/00031348221091957. Epub 2022 May 6. Am Surg. 2023. PMID: 35522851
BACKGROUND: The emergency department (ED) often represents the first exposure orthopedic trauma patients have to prescription opioids and thus a critical opportunity for prevention of potential long-term opioid use. This study will analyze the impact of opioid prescribing …
BACKGROUND: The emergency department (ED) often represents the first exposure orthopedic trauma patients have to prescription opioids and th …
Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative.
Leiting JL, Cloyd JM, Ahmed A, Fournier K, Lee AJ, Dessureault S, Felder S, Veerapong J, Baumgartner JM, Clarke C, Mogal H, Staley CA, Zaidi MY, Patel SH, Ahmad SA, Hendrix RJ, Lambert L, Abbott DE, Pokrzywa C, Raoof M, LaRocca CJ, Johnston FM, Greer J, Grotz TE. Leiting JL, et al. Among authors: staley ca. World J Gastrointest Oncol. 2020 Jul 15;12(7):756-767. doi: 10.4251/wjgo.v12.i7.756. World J Gastrointest Oncol. 2020. PMID: 32864043 Free PMC article.
AIM: To evaluate the impact of HIPEC method on post-operative and long-term survival outcomes. METHODS: Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative database. ...CONCLUSION: In this multi-institutional analysis, …
AIM: To evaluate the impact of HIPEC method on post-operative and long-term survival outcomes. METHODS: Patients undergoing CRS with …
Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk.
Prizment AE, Staley C, Onyeaghala GC, Vivek S, Thyagarajan B, Straka RJ, Demmer RT, Knights D, Meyer KA, Shaukat A, Sadowsky MJ, Church TR. Prizment AE, et al. Among authors: staley c. Aliment Pharmacol Ther. 2020 Sep;52(6):976-987. doi: 10.1111/apt.16013. Epub 2020 Aug 8. Aliment Pharmacol Ther. 2020. PMID: 32770859 Free PMC article. Clinical Trial.
Mixed-effect regression with binomial distribution estimated the effect of aspirin use on changes in the relative abundance of individual bacterial taxa via an interaction term (treatment time). RESULTS: Over the study period, there were differences in microbial compositio …
Mixed-effect regression with binomial distribution estimated the effect of aspirin use on changes in the relative abundance of individual ba …
Impact of Atrazine Exposure on the Microbial Community Structure in a Brazilian Tropical Latosol Soil.
Fernandes AFT, Wang P, Staley C, Aparecida Silva Moretto J, Miguel Altarugio L, Chagas Campanharo S, Guedes Stehling E, Jay Sadowsky M. Fernandes AFT, et al. Among authors: staley c. Microbes Environ. 2020;35(2):ME19143. doi: 10.1264/jsme2.ME19143. Microbes Environ. 2020. PMID: 32269200 Free PMC article.
The present results revealed that while the application of atrazine may temporarily increase the quantities of the atzA and trzN genes in a Brazilian Red Latosol soil, it does not lead to significant and long-term changes in the bacterial community structure....
The present results revealed that while the application of atrazine may temporarily increase the quantities of the atzA and trzN genes in a …
Predictors of Anastomotic Failure After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Does Technique Matter?
Wiseman JT, Kimbrough C, Beal EW, Zaidi MY, Staley CA, Grotz T, Leiting J, Fournier K, Lee AJ, Dineen S, Powers B, Veerapong J, Baumgartner JM, Clarke C, Patel SH, Dhar V, Hendrix RJ, Lambert L, Abbott DE, Pokrzywa C, Raoof M, Lee B, Fackche N, Greer J, Pawlik TM, Abdel-Misih S, Cloyd JM. Wiseman JT, et al. Among authors: staley ca. Ann Surg Oncol. 2020 Mar;27(3):783-792. doi: 10.1245/s10434-019-07964-x. Epub 2019 Oct 28. Ann Surg Oncol. 2020. PMID: 31659645
CONCLUSIONS: Among patients undergoing CRS-HIPEC, AF is independently associated with postoperative morbidity and worse long-term outcomes. Because patient- and tumor-related, but not technical, factors are associated with AF, operative technique may be individualized base …
CONCLUSIONS: Among patients undergoing CRS-HIPEC, AF is independently associated with postoperative morbidity and worse long-term out …
Durable Long-Term Bacterial Engraftment following Encapsulated Fecal Microbiota Transplantation To Treat Clostridium difficile Infection.
Staley C, Kaiser T, Vaughn BP, Graiziger C, Hamilton MJ, Kabage AJ, Khoruts A, Sadowsky MJ. Staley C, et al. mBio. 2019 Jul 23;10(4):e01586-19. doi: 10.1128/mBio.01586-19. mBio. 2019. PMID: 31337728 Free PMC article.
Fecal microbiota transplantation (FMT) has become a common rescue therapy for recurrent Clostridium difficile infection, and encapsulated delivery (cFMT) of healthy donor microbiota shows similar clinical efficacy as more traditional routes of administration. In this study, we ch …
Fecal microbiota transplantation (FMT) has become a common rescue therapy for recurrent Clostridium difficile infection, and encapsulated de …
30 results