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Four-year overall survival update from the phase III HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma.
Sangro B, Chan SL, Kelley RK, Lau G, Kudo M, Sukeepaisarnjaroen W, Yarchoan M, De Toni EN, Furuse J, Kang YK, Galle PR, Rimassa L, Heurgué A, Tam VC, Van Dao T, Thungappa SC, Breder V, Ostapenko Y, Reig M, Makowsky M, Paskow MJ, Gupta C, Kurland JF, Negro A, Abou-Alfa GK; HIMALAYA investigators. Sangro B, et al. Ann Oncol. 2024 Feb 19:S0923-7534(24)00049-8. doi: 10.1016/j.annonc.2024.02.005. Online ahead of print. Ann Oncol. 2024. PMID: 38382875 Free article.
Long-term survivors with STRIDE (n = 103) included participants across clinically relevant subgroups, and 57.3% (59/103) had no reported subsequent anticancer therapy. ...Results continue to support the long-term benefits of STRIDE in a diverse population, reflectiv …
Long-term survivors with STRIDE (n = 103) included participants across clinically relevant subgroups, and 57.3% (59/103) had no repor …
Treatment and follow-up of children with chronic myeloid leukaemia in chronic phase (CML-CP) in the tyrosine kinase inhibitor (TKI) era-Two decades of experience from the Tata Memorial Hospital paediatric CML (pCML) cohort.
Roy Moulik N, Keerthivasagam S, Pandey A, Agiwale J, Hegde K, Chatterjee G, Dhamne C, Prasad M, Chichra A, Srinivasan S, Mohanty P, Jain H, Shetty D, Tembhare P, Patkar N, Narula G, Subramanian PG, Banavali S. Roy Moulik N, et al. Among authors: srinivasan s. Br J Haematol. 2024 Apr;204(4):1249-1261. doi: 10.1111/bjh.19251. Epub 2023 Dec 14. Br J Haematol. 2024. PMID: 38098201
Tyrosine kinase inhibitors (TKIs) have drastically improved the outcomes of pCML (paediatric CML) but data on long-term off-target toxicities of TKIs in children are scarce. In this single-centre, retrospective cum prospective study of pCML in chronic phase, we report our …
Tyrosine kinase inhibitors (TKIs) have drastically improved the outcomes of pCML (paediatric CML) but data on long-term off-target to …
Robotic Kidney Transplant Beyond the Learning Curve: 8-Year Single-center Experience and Matched Comparison With Open Kidney Transplant.
Kishore TA, Kaddu DJ, Sodhi BS, Srinivasan SP, Unni NV. Kishore TA, et al. Among authors: srinivasan sp. Urology. 2024 Jan;183:100-105. doi: 10.1016/j.urology.2023.10.031. Epub 2023 Nov 10. Urology. 2024. PMID: 37952604
OBJECTIVE: To investigate the medium to long-term outcomes of robotic-assisted kidney transplantation (RAKT) and propensity-matched comparison with open kidney transplant (OKT). ...RAKT shows comparable graft and patient survival rates to OKT in the medium to long term …
OBJECTIVE: To investigate the medium to long-term outcomes of robotic-assisted kidney transplantation (RAKT) and propensity-matched c …
Long-term outcomes of liver transplantation for homozygous familial hypercholesterolaemia in Australia and New Zealand.
Page MM, Hardikar W, Alex G, Bates S, Srinivasan S, Stormon M, Hall K, Evans HM, Johnston P, Chen J, Wigg A, John L, Ekinci EI, O'Brien RC, Jones R, Watts GF. Page MM, et al. Among authors: srinivasan s. Atherosclerosis. 2023 Dec;387:117305. doi: 10.1016/j.atherosclerosis.2023.117305. Epub 2023 Oct 10. Atherosclerosis. 2023. PMID: 37863699
Newer drugs including lomitapide and evinacumab might reduce the need for apheresis and LT. We sought to determine the long-term outcomes following LT in Australia and New Zealand. METHODS: We analysed demographic, biochemical and clinical data from all patients in Austral …
Newer drugs including lomitapide and evinacumab might reduce the need for apheresis and LT. We sought to determine the long-term outc …
Detection and classification of adult epilepsy using hybrid deep learning approach.
Srinivasan S, Dayalane S, Mathivanan SK, Rajadurai H, Jayagopal P, Dalu GT. Srinivasan S, et al. Sci Rep. 2023 Oct 16;13(1):17574. doi: 10.1038/s41598-023-44763-7. Sci Rep. 2023. PMID: 37845403 Free PMC article.
Based on five evaluation criteria, the labelled hybrid convolutional auto-encoder (LHCAE) model, which utilizes a classifier based on bidirectional long short-term memory (Bi-LSTM) and an EEG segment length of 4 s, had the best efficiency. ...
Based on five evaluation criteria, the labelled hybrid convolutional auto-encoder (LHCAE) model, which utilizes a classifier based on bidire …
In utero and post-natal opioid exposure followed by mild traumatic brain injury contributes to cortical neuroinflammation, mitochondrial dysfunction, and behavioral deficits in juvenile rats.
Gowen AM, Yi J, Stauch K, Miles L, Srinivasan S, Odegaard K, Pendyala G, Yelamanchili SV. Gowen AM, et al. Among authors: srinivasan s. Brain Behav Immun Health. 2023 Jul 28;32:100669. doi: 10.1016/j.bbih.2023.100669. eCollection 2023 Oct. Brain Behav Immun Health. 2023. PMID: 37588011 Free PMC article.
Using a rat model of in utero and post-natal oxycodone (IUO) exposure and a low force weight drop model of mTBI, we show that not only neonatal opioid exposure significantly affects neuroinflammation, brain metabolites, synaptic proteome, mitochondrial function, and altered behav …
Using a rat model of in utero and post-natal oxycodone (IUO) exposure and a low force weight drop model of mTBI, we show that not only neona …
Clinico-radiological profile, management and follow-up of methotrexate induced neurotoxicity in children with acute lymphoblastic leukemia.
Dhariwal N, Roy Moulik N, Smriti V, Dhamne C, Chichra A, Srinivasan S, Narula G, Banavali S. Dhariwal N, et al. Among authors: srinivasan s. Leuk Lymphoma. 2023 Dec;64(12):1971-1980. doi: 10.1080/10428194.2023.2245093. Epub 2023 Aug 11. Leuk Lymphoma. 2023. PMID: 37565568
With emerging evidence, thirty-one patients were re-challenged with methotrexate (IV/IT), of whom 4 patients had recurrence of symptoms. No long-term neurological sequalae were noted in our cohort, despite rechallenging. ...
With emerging evidence, thirty-one patients were re-challenged with methotrexate (IV/IT), of whom 4 patients had recurrence of symptoms. No …
Treatment of Pediatric Acute Promyelocytic Leukemia with Retinoic Acid and Arsenic Trioxide along with Chemotherapy.
Srinivasan S, Dhamne C, Moulik NR, Chichra A, Tembhare P, Patkar N, Subramanian PG, Shetty D, Narula G, Banavali S. Srinivasan S, et al. Indian J Pediatr. 2023 Jun 29. doi: 10.1007/s12098-023-04689-4. Online ahead of print. Indian J Pediatr. 2023. PMID: 37380920
Two of 4 patients with relapse of disease could be salvaged with only differentiating agents followed by autologous transplantation. CONCLUSIONS: Long-term outcomes of Indian children with APL are excellent. Timely management of coagulopathy and prompt initiation of differ …
Two of 4 patients with relapse of disease could be salvaged with only differentiating agents followed by autologous transplantation. CONCLUS …
Greater Improvement in Obesity Among Children With Prediabetes in a Clinical Weight Management Program.
Tester JM, Xiao L, Chau CA, Tinajero-Deck L, Srinivasan S, Rosas LG. Tester JM, et al. Among authors: srinivasan s. Child Obes. 2023 Jun 21. doi: 10.1089/chi.2022.0234. Online ahead of print. Child Obes. 2023. PMID: 37347933
Random effects (individual growth curves) and fixed effects (prediabetes status, starting age and %BMIp95, sex, race/ethnicity, and linear slope and quadratic term of months since the initial visit) were modeled. Interactions between prediabetes and elapsed time estimated …
Random effects (individual growth curves) and fixed effects (prediabetes status, starting age and %BMIp95, sex, race/ethnicity, and linear s …
Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies.
Venkatesan V, Christopher AC, Rhiel M, Azhagiri MKK, Babu P, Walavalkar K, Saravanan B, Andrieux G, Rangaraj S, Srinivasan S, Karuppusamy KV, Jacob A, Bagchi A, Pai AA, Nakamura Y, Kurita R, Balasubramanian P, Pai R, Marepally SK, Mohankumar KM, Velayudhan SR, Boerries M, Notani D, Cathomen T, Srivastava A, Thangavel S. Venkatesan V, et al. Among authors: srinivasan s. Mol Ther Nucleic Acids. 2023 Apr 26;32:671-688. doi: 10.1016/j.omtn.2023.04.024. eCollection 2023 Jun 13. Mol Ther Nucleic Acids. 2023. PMID: 37215154 Free PMC article.
PRR-betaE1-edited hematopoietic stem and progenitor cells (HSPCs) retained their genome integrity and their engraftment potential to repopulate for long-term hematopoiesis in immunocompromised mice producing HbF positive cells in vivo. ...
PRR-betaE1-edited hematopoietic stem and progenitor cells (HSPCs) retained their genome integrity and their engraftment potential to repopul …
133 results