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Impact of direct-acting antiviral agents on liver function in patients with chronic hepatitis C virus infection.
Johnson PJ, Berhane S, Walker AJ, Gordon FH, Ryder SD, McPherson S, Sreedharan A, Ustianowski AA, Agarwal K, Mutimer D, Kumada T, Toyoda H, Irving WL; HCV Research UK. Johnson PJ, et al. Among authors: sreedharan a. J Viral Hepat. 2021 Jan;28(1):168-176. doi: 10.1111/jvh.13408. Epub 2020 Nov 2. J Viral Hepat. 2021. PMID: 32978982
Experience with interferon-based therapy suggests that failure to achieve SVR is associated with long-term decline in liver function and, in contrast, patients who do achieve SVR can expect long-term disease improvement and subsequent stabilization of liver function …
Experience with interferon-based therapy suggests that failure to achieve SVR is associated with long-term decline in liver function …
Prednisolone or pentoxifylline for alcoholic hepatitis.
Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, Downs N, Gleeson D, MacGilchrist A, Grant A, Hood S, Masson S, McCune A, Mellor J, O'Grady J, Patch D, Ratcliffe I, Roderick P, Stanton L, Vergis N, Wright M, Ryder S, Forrest EH; STOPAH Trial. Thursz MR, et al. N Engl J Med. 2015 Apr 23;372(17):1619-28. doi: 10.1056/NEJMoa1412278. N Engl J Med. 2015. PMID: 25901427 Free article. Clinical Trial.
BACKGROUND: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease exceeds 30%. Prednisolone and pentox …
BACKGROUND: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history …
The cost of treatment failure: resource use and costs incurred by hepatitis C virus genotype 1-infected patients who do or do not achieve sustained virological response to therapy.
Backx M, Lewszuk A, White JR, Cole J, Sreedharan A, van Sanden S, Diels J, Lawson A, Neal KR, Wiselka MJ, Ito T, Irving WL. Backx M, et al. Among authors: sreedharan a. J Viral Hepat. 2014 Mar;21(3):208-15. doi: 10.1111/jvh.12132. Epub 2013 Aug 1. J Viral Hepat. 2014. PMID: 24438682
Cost-effectiveness analyses of antiviral treatment for patients with chronic HCV infection are dependent on assumptions about cost reductions following sustained virological response (SVR) to therapy. This study quantified the medium-term difference in health resource usag …
Cost-effectiveness analyses of antiviral treatment for patients with chronic HCV infection are dependent on assumptions about cost reduction …
Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding.
Leontiadis GI, Sreedharan A, Dorward S, Barton P, Delaney B, Howden CW, Orhewere M, Gisbert J, Sharma VK, Rostom A, Moayyedi P, Forman D. Leontiadis GI, et al. Among authors: sreedharan a. Health Technol Assess. 2007 Dec;11(51):iii-iv, 1-164. doi: 10.3310/hta11510. Health Technol Assess. 2007. PMID: 18021578 Free article. Review.
Giving oral PPI both before and after endoscopy, with endoscopic haemostatic therapy (EHT) for those with major SRH, is preferred to all others on cost-effectiveness grounds at any threshold over 25,000 pounds per QALY, even if only short-term effects are taken into accoun …
Giving oral PPI both before and after endoscopy, with endoscopic haemostatic therapy (EHT) for those with major SRH, is preferred to all oth …
Macrophage activation syndrome and other systemic inflammatory conditions after BMT.
Sreedharan A, Bowyer S, Wallace CA, Robertson MJ, Schmidt K, Woolfrey AE, Nelson RP Jr. Sreedharan A, et al. Bone Marrow Transplant. 2006 Apr;37(7):629-34. doi: 10.1038/sj.bmt.1705305. Bone Marrow Transplant. 2006. PMID: 16501594 Review.
Autologous hematopoietic cell transplantation (HCT) is being used to treat autoimmune diseases refractory to conventional therapy, including rheumatoid arthritis. Macrophage activation syndrome (MAS) is a descriptive term for a systemic inflammatory disorder that has been …
Autologous hematopoietic cell transplantation (HCT) is being used to treat autoimmune diseases refractory to conventional therapy, including …
Cost-effectiveness and long-term impact of Helicobacter pylori 'test and treat' service in reducing open access endoscopy referrals.
Sreedharan A, Clough M, Hemingbrough E, Gatta L, Chalmers DM, Axon AT, Moayyedi P. Sreedharan A, et al. Eur J Gastroenterol Hepatol. 2004 Oct;16(10):981-6. doi: 10.1097/00042737-200410000-00005. Eur J Gastroenterol Hepatol. 2004. PMID: 15371920

INTRODUCTION: We have shown that the introduction of a carbon urea breath test (13C-UBT) service for Helicobacter pylori screening and eradication is effective in reducing the rate of open access endoscopy referrals in patients aged < 40 years in the short term. This ha

INTRODUCTION: We have shown that the introduction of a carbon urea breath test (13C-UBT) service for Helicobacter pylori screening and eradi …
The transplantation of human fetal neuroretinal cells in advanced retinitis pigmentosa patients: results of a long-term safety study.
Das T, del Cerro M, Jalali S, Rao VS, Gullapalli VK, Little C, Loreto DA, Sharma S, Sreedharan A, del Cerro C, Rao GN. Das T, et al. Among authors: sreedharan a. Exp Neurol. 1999 May;157(1):58-68. doi: 10.1006/exnr.1998.6992. Exp Neurol. 1999. PMID: 10222108 Clinical Trial.
The purpose of this study was to determine the long-term safety of transplanting human fetal neuroretinal cells (14 to 18 week gestational age) into a series of patients with advanced retinitis pigmentosa (RP). ...
The purpose of this study was to determine the long-term safety of transplanting human fetal neuroretinal cells (14 to 18 week gestat …