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Transforming research to improve therapies for trauma in the twenty-first century.
Juffermans NP, Gözden T, Brohi K, Davenport R, Acker JP, Reade MC, Maegele M, Neal MD, Spinella PC. Juffermans NP, et al. Among authors: spinella pc. Crit Care. 2024 Feb 13;28(1):45. doi: 10.1186/s13054-024-04805-6. Crit Care. 2024. PMID: 38350971 Free PMC article. Review.
Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. However, as specific treatments for bleeding are largely lacking, man …
Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency departmen …
Cold-stored platelet hemostatic capacity is maintained for three weeks of storage and associated with taurine metabolism.
Shea SM, Reisz JA, Mihalko EP, Rahn KC, Rassam RMG, Chitrakar A, Gamboni F, D'Alessandro A, Spinella PC, Thomas KA. Shea SM, et al. Among authors: spinella pc. J Thromb Haemost. 2024 Apr;22(4):1154-1166. doi: 10.1016/j.jtha.2023.11.025. Epub 2023 Dec 9. J Thromb Haemost. 2024. PMID: 38072374
Cold-stored PLT (CS-PLT) maintain hemostatic potential better than room temperature-stored PLT (RT-PLT). However, whether function in long-term CS-PLT is maintained under physiological flow regimes and/or determined by cold-induced metabolic changes is unknown. ...
Cold-stored PLT (CS-PLT) maintain hemostatic potential better than room temperature-stored PLT (RT-PLT). However, whether function in long- …
The role of sodium citrate during extended cold storage of platelets in platelet additive solutions.
Johnson L, Roan C, Lei P, Spinella PC, Marks DC. Johnson L, et al. Among authors: spinella pc. Transfusion. 2023 May;63 Suppl 3:S126-S137. doi: 10.1111/trf.17328. Epub 2023 Apr 17. Transfusion. 2023. PMID: 36971024
Supplementation of PAS-F with 11 mM sodium citrate improved the platelet content, maintained the pH above specifications and prevented aggregate formation. DISCUSSION: In vitro parameters were similar during short-term cold storage of platelets in PAS-E and PAS-F. Storage …
Supplementation of PAS-F with 11 mM sodium citrate improved the platelet content, maintained the pH above specifications and prevented aggre …
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.
LaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV, McLaughlin GE, Son MBF, Maddux AB, Clouser KN, Rowan CM, McGuire JK, Fitzgerald JC, Gertz SJ, Shein SL, Munoz AC, Thomas NJ, Irby K, Levy ER, Staat MA, Tenforde MW, Feldstein LR, Halasa NB, Giuliano JS Jr, Hall MW, Kong M, Carroll CL, Schuster JE, Doymaz S, Loftis LL, Tarquinio KM, Babbitt CJ, Nofziger RA, Kleinman LC, Keenaghan MA, Cvijanovich NZ, Spinella PC, Hume JR, Wellnitz K, Mack EH, Michelson KN, Flori HR, Patel MM, Randolph AG; Overcoming COVID-19 Investigators. LaRovere KL, et al. Among authors: spinella pc. JAMA Neurol. 2021 May 1;78(5):536-547. doi: 10.1001/jamaneurol.2021.0504. JAMA Neurol. 2021. PMID: 33666649 Free PMC article.
A range of life-threatening and fatal neurologic conditions associated with COVID-19 infrequently occurred. Effects on long-term neurodevelopmental outcomes are unknown....
A range of life-threatening and fatal neurologic conditions associated with COVID-19 infrequently occurred. Effects on long-term neur …
A Pilot Trial of Platelets Stored Cold versus at Room Temperature for Complex Cardiothoracic Surgery.
Strandenes G, Sivertsen J, Bjerkvig CK, Fosse TK, Cap AP, Del Junco DJ, Kristoffersen EK, Haaverstad R, Kvalheim V, Braathen H, Lunde THF, Hervig T, Hufthammer KO, Spinella PC, Apelseth TO. Strandenes G, et al. Among authors: spinella pc. Anesthesiology. 2020 Dec 1;133(6):1173-1183. doi: 10.1097/ALN.0000000000003550. Anesthesiology. 2020. PMID: 32902572 Free article. Clinical Trial.
Secondary outcomes were platelet function measured by multiple electrode impedance aggregometry, total blood usage, immediate and long-term (28 days) adverse events, length of stay in intensive care, and mortality. ...
Secondary outcomes were platelet function measured by multiple electrode impedance aggregometry, total blood usage, immediate and long-te …
The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.
Shea SM, Thomas KA, Spinella PC. Shea SM, et al. Among authors: spinella pc. Blood Transfus. 2019 Jul;17(4):321-330. doi: 10.2450/2019.0095-19. Blood Transfus. 2019. PMID: 31385802 Free PMC article. Review.
In particular, cold storage of platelet products causes many biochemical and functional changes, of which the most notable characterised to date include increased haemostatic activity and altered expression of molecules inherent to platelet:leucocyte interactions. The in vivo con …
In particular, cold storage of platelet products causes many biochemical and functional changes, of which the most notable characterised to …
The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial.
Tucci M, Lacroix J, Fergusson D, Doctor A, Hébert P, Berg RA, Caro J, Josephson CD, Leteurtre S, Menon K, Schechtman K, Steiner ME, Turgeon AF, Clayton L, Bockelmann T, Spinella PC; Canadian Critical Care Trials Group; Pediatric Critical Care Blood Research Network (BloodNet); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Tucci M, et al. Among authors: spinella pc. Trials. 2018 Jul 28;19(1):404. doi: 10.1186/s13063-018-2809-y. Trials. 2018. PMID: 30055634 Free PMC article.
While RBCs can be stored for up to 42 days in additive solutions, their efficacy and safety after long-term storage have been challenged. Preclinical and clinical observational evidence suggests loss of efficacy and lack of safety of older RBC units, especially in more vul …
While RBCs can be stored for up to 42 days in additive solutions, their efficacy and safety after long-term storage have been challen …
The research agenda for trauma critical care.
Asehnoune K, Balogh Z, Citerio G, Cap A, Billiar T, Stocchetti N, Cohen MJ, Pelosi P, Curry N, Gaarder C, Gruen R, Holcomb J, Hunt BJ, Juffermans NP, Maegele M, Midwinter M, Moore FA, O'Dwyer M, Pittet JF, Schöchl H, Schreiber M, Spinella PC, Stanworth S, Winfield R, Brohi K. Asehnoune K, et al. Among authors: spinella pc. Intensive Care Med. 2017 Sep;43(9):1340-1351. doi: 10.1007/s00134-017-4895-9. Epub 2017 Jul 29. Intensive Care Med. 2017. PMID: 28756471 Review.
Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Prediction of the long-term outcome early after TBI remains challenging. Early magnetic resonance imaging has recently been evaluated for pr …
Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Predict …
Isolated pediatric burn injury in Iraq and Afghanistan.
Borgman MA, Matos RI, Spinella PC. Borgman MA, et al. Among authors: spinella pc. Pediatr Crit Care Med. 2015 Feb;16(2):e23-7. doi: 10.1097/PCC.0000000000000307. Pediatr Crit Care Med. 2015. PMID: 25560430

Children with severe burns (total body surface area > 39% or > 29% if < 5 yr) had a high mortality and required significant resources in a setting that is not primarily resourced for long-term care of severe pediatric burn injury. Extraordinary measures are theref

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Children with severe burns (total body surface area > 39% or > 29% if < 5 yr) had a high mortality and required significant resourc

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Red blood cell transfusion and immune function in critically ill children: a prospective observational study.
Muszynski JA, Frazier E, Nofziger R, Nateri J, Hanson-Huber L, Steele L, Nicol K, Spinella PC, Hall MW; Pediatric Critical Care Blood Research Network (Blood Net) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Muszynski JA, et al. Among authors: spinella pc. Transfusion. 2015 Apr;55(4):766-74. doi: 10.1111/trf.12896. Epub 2014 Oct 29. Transfusion. 2015. PMID: 25355535
This was not seen with fresher RBCs. RBC transfusion had no short-term association with adaptive immune function. Further studies are warranted to confirm these findings in a larger cohort of patients....
This was not seen with fresher RBCs. RBC transfusion had no short-term association with adaptive immune function. Further studies are …
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