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The research agenda for trauma critical care.
Asehnoune K, Balogh Z, Citerio G, Cap A, Billiar T, Stocchetti N, Cohen MJ, Pelosi P, Curry N, Gaarder C, Gruen R, Holcomb J, Hunt BJ, Juffermans NP, Maegele M, Midwinter M, Moore FA, O'Dwyer M, Pittet JF, Schöchl H, Schreiber M, Spinella PC, Stanworth S, Winfield R, Brohi K. Asehnoune K, et al. Among authors: spinella pc. Intensive Care Med. 2017 Sep;43(9):1340-1351. doi: 10.1007/s00134-017-4895-9. Epub 2017 Jul 29. Intensive Care Med. 2017. PMID: 28756471 Review.
Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Prediction of the long-term outcome early after TBI remains challenging. Early magnetic resonance imaging has recently been evaluated for pr …
Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Predict …
Short-Term but not Long-Term Blood Pressure Variability Is a Predictor of Adverse Cardiovascular Outcomes in Young Untreated Hypertensives.
Saladini F, Fania C, Mos L, Vriz O, Mazzer A, Spinella P, Garavelli G, Ermolao A, Rattazzi M, Palatini P. Saladini F, et al. Among authors: spinella p. Am J Hypertens. 2020 Nov 3;33(11):1030-1037. doi: 10.1093/ajh/hpaa121. Am J Hypertens. 2020. PMID: 32710778
BACKGROUND: Whether blood pressure variability (BPV) measured with ambulatory monitoring (short-term BPV) or computed from office visits (long-term BPV) are related to each other and carry similar prognostic information is not well known. ...Short-term BPV wa …
BACKGROUND: Whether blood pressure variability (BPV) measured with ambulatory monitoring (short-term BPV) or computed from office vis …
Optimal use of blood in trauma patients.
Holcomb JB, Spinella PC. Holcomb JB, et al. Among authors: spinella pc. Biologicals. 2010 Jan;38(1):72-7. doi: 10.1016/j.biologicals.2009.10.007. Epub 2010 Jan 13. Biologicals. 2010. PMID: 20074980 Free PMC article. Review.
Finally, blood components themselves have evolved over the last 30 years, with great attention paid to product safety and inventory management, yet there are surprisingly limited clinical outcome data describing the long term effects of these changes, or how the components …
Finally, blood components themselves have evolved over the last 30 years, with great attention paid to product safety and inventory manageme …
Transforming research to improve therapies for trauma in the twenty-first century.
Juffermans NP, Gözden T, Brohi K, Davenport R, Acker JP, Reade MC, Maegele M, Neal MD, Spinella PC. Juffermans NP, et al. Among authors: spinella pc. Crit Care. 2024 Feb 13;28(1):45. doi: 10.1186/s13054-024-04805-6. Crit Care. 2024. PMID: 38350971 Free PMC article. Review.
Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. However, as specific treatments for bleeding are largely lacking, man …
Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency departmen …
The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.
Shea SM, Thomas KA, Spinella PC. Shea SM, et al. Among authors: spinella pc. Blood Transfus. 2019 Jul;17(4):321-330. doi: 10.2450/2019.0095-19. Blood Transfus. 2019. PMID: 31385802 Free PMC article. Review.
In particular, cold storage of platelet products causes many biochemical and functional changes, of which the most notable characterised to date include increased haemostatic activity and altered expression of molecules inherent to platelet:leucocyte interactions. The in vivo con …
In particular, cold storage of platelet products causes many biochemical and functional changes, of which the most notable characterised to …
Short-term blood pressure variability outweighs average 24-h blood pressure in the prediction of cardiovascular events in hypertension of the young.
Palatini P, Saladini F, Mos L, Fania C, Mazzer A, Cozzio S, Zanata G, Garavelli G, Biasion T, Spinella P, Vriz O, Casiglia E, Reboldi G. Palatini P, et al. Among authors: spinella p. J Hypertens. 2019 Jul;37(7):1419-1426. doi: 10.1097/HJH.0000000000002074. J Hypertens. 2019. PMID: 30882599
OBJECTIVE: The association of short-term blood pressure (BP) variability (BPV) with cardiovascular events (CVEs) is controversial. ...Of note, in all Cox models average 24-h BP was no longer an independent predictor of outcome after BPV was included. CONCLUSION: Short-t
OBJECTIVE: The association of short-term blood pressure (BP) variability (BPV) with cardiovascular events (CVEs) is controversial. .. …
Caffeine intake reduces incident atrial fibrillation at a population level.
Casiglia E, Tikhonoff V, Albertini F, Gasparotti F, Mazza A, Montagnana M, Danese E, Benati M, Spinella P, Palatini P. Casiglia E, et al. Among authors: spinella p. Eur J Prev Cardiol. 2018 Jul;25(10):1055-1062. doi: 10.1177/2047487318772945. Epub 2018 Apr 25. Eur J Prev Cardiol. 2018. PMID: 29692210
Age, chronic pulmonary disease, history of heart failure and of coronary artery disease, and systolic blood pressure - but not the genotype or the caffeine CYP1A2 interaction term - were significant confounders of the association between incident atrial fibrillation and be …
Age, chronic pulmonary disease, history of heart failure and of coronary artery disease, and systolic blood pressure - but not the genotype …
The role of sodium citrate during extended cold storage of platelets in platelet additive solutions.
Johnson L, Roan C, Lei P, Spinella PC, Marks DC. Johnson L, et al. Among authors: spinella pc. Transfusion. 2023 May;63 Suppl 3:S126-S137. doi: 10.1111/trf.17328. Epub 2023 Apr 17. Transfusion. 2023. PMID: 36971024
Supplementation of PAS-F with 11 mM sodium citrate improved the platelet content, maintained the pH above specifications and prevented aggregate formation. DISCUSSION: In vitro parameters were similar during short-term cold storage of platelets in PAS-E and PAS-F. Storage …
Supplementation of PAS-F with 11 mM sodium citrate improved the platelet content, maintained the pH above specifications and prevented aggre …
Combined Before-and-After Workplace Intervention to Promote Healthy Lifestyles in Healthcare Workers (STI-VI Study): Short-Term Assessment.
Scapellato ML, Comiati V, Buja A, Buttignol G, Valentini R, Burati V, La Serra L, Maccà I, Mason P, Scopa P, Volpin A, Trevisan A, Spinella P. Scapellato ML, et al. Among authors: spinella p. Int J Environ Res Public Health. 2018 Sep 19;15(9):2053. doi: 10.3390/ijerph15092053. Int J Environ Res Public Health. 2018. PMID: 30235849 Free PMC article. Clinical Trial.
Cold-stored platelet hemostatic capacity is maintained for three weeks of storage and associated with taurine metabolism.
Shea SM, Reisz JA, Mihalko EP, Rahn KC, Rassam RMG, Chitrakar A, Gamboni F, D'Alessandro A, Spinella PC, Thomas KA. Shea SM, et al. Among authors: spinella pc. J Thromb Haemost. 2024 Apr;22(4):1154-1166. doi: 10.1016/j.jtha.2023.11.025. Epub 2023 Dec 9. J Thromb Haemost. 2024. PMID: 38072374
Cold-stored PLT (CS-PLT) maintain hemostatic potential better than room temperature-stored PLT (RT-PLT). However, whether function in long-term CS-PLT is maintained under physiological flow regimes and/or determined by cold-induced metabolic changes is unknown. ...
Cold-stored PLT (CS-PLT) maintain hemostatic potential better than room temperature-stored PLT (RT-PLT). However, whether function in long- …
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