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Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target.
Bhongsatiern J, Stockmann C, Roberts JK, Yu T, Korgenski KE, Spigarelli MG, Desai PB, Sherwin CM. Bhongsatiern J, et al. Among authors: spigarelli mg. Ther Drug Monit. 2015 Dec;37(6):756-65. doi: 10.1097/FTD.0000000000000216. Ther Drug Monit. 2015. PMID: 26562817 Free PMC article.
AIM: To develop a vancomycin population pharmacokinetic model and assess the probability of attaining a pharmacodynamic target associated with clinical and microbiological success, a ratio of the 24-hour area under the concentration-time curve to the minimum inhibitory concentrat …
AIM: To develop a vancomycin population pharmacokinetic model and assess the probability of attaining a pharmacodynamic target associated wi …
Comanagement of Pediatric Depression and Obesity: A Clear Need for Evidence.
Mihalopoulos NL, Spigarelli MG. Mihalopoulos NL, et al. Among authors: spigarelli mg. Clin Ther. 2015 Sep 1;37(9):1933-7. doi: 10.1016/j.clinthera.2015.08.009. Epub 2015 Aug 29. Clin Ther. 2015. PMID: 26321691 Free PMC article. Review.
Bariatric surgery may play a role in some adolescents, but larger and long-term clinical studies with the use of therapeutic agents in conjunction with lifestyle modification need to be conducted to support this. ...
Bariatric surgery may play a role in some adolescents, but larger and long-term clinical studies with the use of therapeutic agents i …
Neonatal magnesium levels correlate with motor outcomes in premature infants: a long-term retrospective cohort study.
Doll E, Wilkes J, Cook LJ, Korgenski EK, Faix RG, Yoder BA, Srivastava R, Sherwin CM, Spigarelli MG, Clark EA, Bonkowsky JL. Doll E, et al. Among authors: spigarelli mg. Front Pediatr. 2014 Nov 5;2:120. doi: 10.3389/fped.2014.00120. eCollection 2014. Front Pediatr. 2014. PMID: 25414842 Free PMC article.
Our objective was to determine whether higher neonatal serum magnesium levels were associated with better long-term neurodevelopmental outcomes in very-low birth weight infants. ...CONCLUSION: This study demonstrates a correlation between higher neonatal magnesium l …
Our objective was to determine whether higher neonatal serum magnesium levels were associated with better long-term neurodevelopmenta …
Development of an optimal sampling schedule for children receiving ketamine for short-term procedural sedation and analgesia.
Sherwin CM, Stockmann C, Grimsrud K, Herd DW, Anderson BJ, Spigarelli MG. Sherwin CM, et al. Among authors: spigarelli mg. Paediatr Anaesth. 2015 Feb;25(2):211-6. doi: 10.1111/pan.12521. Epub 2014 Sep 12. Paediatr Anaesth. 2015. PMID: 25212712
CONCLUSION: An optimal sampling schedule was developed that allowed assessment of the pharmacokinetic parameters of ketamine among children requiring short-term procedural sedation....
CONCLUSION: An optimal sampling schedule was developed that allowed assessment of the pharmacokinetic parameters of ketamine among children …
Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity.
Schoen K, Yu T, Stockmann C, Spigarelli MG, Sherwin CM. Schoen K, et al. Among authors: spigarelli mg. Paediatr Drugs. 2014 Apr;16(2):169-77. doi: 10.1007/s40272-013-0063-z. Paediatr Drugs. 2014. PMID: 24399614 Free PMC article. Review.
Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more than 80 % of neonates with a birth weight less than 1,000 g. ...When used as a therapeutic agent, larger doses of caffeine citrate have been shown to improve acute neonatal outc …
Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more than 80 % of neonates with a birth we …
Considerations in the pharmacologic treatment and prevention of neonatal sepsis.
Stockmann C, Spigarelli MG, Campbell SC, Constance JE, Courter JD, Thorell EA, Olson J, Sherwin CM. Stockmann C, et al. Among authors: spigarelli mg. Paediatr Drugs. 2014 Feb;16(1):67-81. doi: 10.1007/s40272-013-0057-x. Paediatr Drugs. 2014. PMID: 24218112 Review.
Antifungal prophylaxis with fluconazole has also been reported to dramatically reduce rates of neonatal invasive fungal infections and to improve long-term neurodevelopmental outcomes among treated children. Additionally, several large multicenter studies are currently inv …
Antifungal prophylaxis with fluconazole has also been reported to dramatically reduce rates of neonatal invasive fungal infections and to im …
Retrospective review of the relationship between weight change and demographic factors following initial depot medroxyprogesterone acetate injection in adolescents.
Gerlach LS, Saldaña SN, Wang Y, Nick TG, Spigarelli MG. Gerlach LS, et al. Among authors: spigarelli mg. Clin Ther. 2011 Feb;33(2):182-7. doi: 10.1016/j.clinthera.2011.02.008. Epub 2011 Mar 12. Clin Ther. 2011. PMID: 21397330 Review.
DMPA is an increasingly popular contraceptive choice for adolescents, yet its use is associated with weight gain as well as subsequent nonadherence and long-term obesity-related diseases and mortality. Precise risk factors for DMPA-associated weight gain and the time perio …
DMPA is an increasingly popular contraceptive choice for adolescents, yet its use is associated with weight gain as well as subsequent nonad …