Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

11 results

Filters applied: . Clear all
Page 1
Long-Term Evolution of Burkholderia multivorans during a Chronic Cystic Fibrosis Infection Reveals Shifting Forces of Selection.
Silva IN, Santos PM, Santos MR, Zlosnik JE, Speert DP, Buskirk SW, Bruger EL, Waters CM, Cooper VS, Moreira LM. Silva IN, et al. Among authors: speert dp. mSystems. 2016 May 24;1(3):e00029-16. doi: 10.1128/mSystems.00029-16. eCollection 2016 May-Jun. mSystems. 2016. PMID: 27822534 Free PMC article.
All together, our observations suggest that selection on B. multivorans populations during long-term colonization of CF patient lungs either directly or indirectly targets adherence, metabolism, and changes in the cell envelope related to adaptation to the biofilm lifestyl …
All together, our observations suggest that selection on B. multivorans populations during long-term colonization of CF patient lungs …
Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada. 30 years' experience.
Zlosnik JE, Zhou G, Brant R, Henry DA, Hird TJ, Mahenthiralingam E, Chilvers MA, Wilcox P, Speert DP. Zlosnik JE, et al. Among authors: speert dp. Ann Am Thorac Soc. 2015 Jan;12(1):70-8. doi: 10.1513/AnnalsATS.201408-395OC. Ann Am Thorac Soc. 2015. PMID: 25474359
During this time, our understanding of their multispecies taxonomy and infection control has evolved substantially. OBJECTIVES: To evaluate the long-term (30 year) epidemiology and clinical outcome of Burkholderia infection in CF, and fully define the risks associated with …
During this time, our understanding of their multispecies taxonomy and infection control has evolved substantially. OBJECTIVES: To evaluate …
Pseudomonas aeruginosa enhances production of a non-alginate exopolysaccharide during long-term colonization of the cystic fibrosis lung.
Huse HK, Kwon T, Zlosnik JE, Speert DP, Marcotte EM, Whiteley M. Huse HK, et al. Among authors: speert dp. PLoS One. 2013 Dec 6;8(12):e82621. doi: 10.1371/journal.pone.0082621. eCollection 2013. PLoS One. 2013. PMID: 24324811 Free PMC article.
Because CF lacks an animal model that can acquire chronic P. aeruginosa infections, identifying genes important for long-term in vivo fitness remains difficult. However, since clonal, chronological samples can be obtained from chronically infected individuals, traits under …
Because CF lacks an animal model that can acquire chronic P. aeruginosa infections, identifying genes important for long-term in vivo …
Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life.
Reikie BA, Naidoo S, Ruck CE, Slogrove AL, de Beer C, la Grange H, Adams RC, Ho K, Smolen K, Speert DP, Cotton MF, Preiser W, Esser M, Kollmann TR. Reikie BA, et al. Among authors: speert dp. Clin Vaccine Immunol. 2013 Jan;20(1):33-8. doi: 10.1128/CVI.00557-12. Epub 2012 Oct 31. Clin Vaccine Immunol. 2013. PMID: 23114697 Free PMC article.
The possibility exists that altered response to vaccination contributes to the higher rate of infection in HEU than in HUU infants. While short-term, cross-sectional studies support this notion, it is unclear whether or not HEU infants develop long-term protective i …
The possibility exists that altered response to vaccination contributes to the higher rate of infection in HEU than in HUU infants. While sh …
Metabolic adaptations of Pseudomonas aeruginosa during cystic fibrosis chronic lung infections.
Behrends V, Ryall B, Zlosnik JE, Speert DP, Bundy JG, Williams HD. Behrends V, et al. Among authors: speert dp. Environ Microbiol. 2013 Feb;15(2):398-408. doi: 10.1111/j.1462-2920.2012.02840.x. Epub 2012 Aug 8. Environ Microbiol. 2013. PMID: 22882524
Understanding how this opportunistic pathogen adapts to the CF lung during chronic infections is important to increase the efficacy of treatment and is likely to increase insight into other long-term infections. Previous studies of P. aeruginosa adaptation and divergence i …
Understanding how this opportunistic pathogen adapts to the CF lung during chronic infections is important to increase the efficacy of treat …
Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants.
Lavoie PM, Ladd M, Hirschfeld AF, Huusko J, Mahlman M, Speert DP, Hallman M, Lacaze-Masmonteil T, Turvey SE. Lavoie PM, et al. Among authors: speert dp. PLoS One. 2012;7(2):e31351. doi: 10.1371/journal.pone.0031351. Epub 2012 Feb 14. PLoS One. 2012. PMID: 22348075 Free PMC article.
In this study, we analyzed two population-based cohorts of preterm infants at risk for BPD as well as ethnicity-matched infants born at term, to test whether the TLR4 polymorphisms Asp299Gly (rs4986790) and Thr399Ile (rs4986791) are independently associated with BPD or pre …
In this study, we analyzed two population-based cohorts of preterm infants at risk for BPD as well as ethnicity-matched infants born at t …
Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.
Silva IN, Ferreira AS, Becker JD, Zlosnik JEA, Speert DP, He J, Mil-Homens D, Moreira LM. Silva IN, et al. Among authors: speert dp. Microbiology (Reading). 2011 Nov;157(Pt 11):3124-3137. doi: 10.1099/mic.0.050989-0. Epub 2011 Aug 11. Microbiology (Reading). 2011. PMID: 21835880 Free article.
Burkholderia cepacia complex (Bcc) bacteria are opportunistic pathogens infecting hosts such as cystic fibrosis (CF) patients. Long-term Bcc infection of CF patients' airways has been associated with emergence of phenotypic variation. ...
Burkholderia cepacia complex (Bcc) bacteria are opportunistic pathogens infecting hosts such as cystic fibrosis (CF) patients. Long-term …
Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.
Lavoie PM, Huang Q, Jolette E, Whalen M, Nuyt AM, Audibert F, Speert DP, Lacaze-Masmonteil T, Soudeyns H, Kollmann TR. Lavoie PM, et al. Among authors: speert dp. J Infect Dis. 2010 Dec 1;202(11):1754-63. doi: 10.1086/657143. Epub 2010 Oct 26. J Infect Dis. 2010. PMID: 20977341 Free PMC article.
METHODS: To investigate homeostatic immune control early in life, we used advanced multiparameter flow cytometry to compare responses to multiple Toll-like receptor (TLR) ligands in single cells and mononuclear cell populations in term neonates versus preterm neonates born …
METHODS: To investigate homeostatic immune control early in life, we used advanced multiparameter flow cytometry to compare responses to mul …
Chlamydia pneumoniae infection in preeclampsia.
Xie F, Hu Y, Magee LA, Money DM, Patrick DM, Brunham RM, Thomas E, von Dadelszen P; Toxaemia group. Xie F, et al. Hypertens Pregnancy. 2010;29(4):468-77. doi: 10.3109/10641950903242642. Hypertens Pregnancy. 2010. PMID: 20818953
STUDY DESIGN: A case-control study was performed on 50 women with preeclampsia, 57 women with normal pregnancies at term, and 25 non-pregnant controls. Anti-C. pneumoniae antibodies were examined by enzyme-linked immunosorbent assay and C. pneumoniae genomic DNA (gDNA) loa …
STUDY DESIGN: A case-control study was performed on 50 women with preeclampsia, 57 women with normal pregnancies at term, and 25 non- …
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.
Smith EE, Buckley DG, Wu Z, Saenphimmachak C, Hoffman LR, D'Argenio DA, Miller SI, Ramsey BW, Speert DP, Moskowitz SM, Burns JL, Kaul R, Olson MV. Smith EE, et al. Among authors: speert dp. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8487-92. doi: 10.1073/pnas.0602138103. Epub 2006 May 10. Proc Natl Acad Sci U S A. 2006. PMID: 16687478 Free PMC article.
With the exception of intensively studied viral infections such as HIV/AIDs, little is known about the extent to which the clonal expansion that occurs during long-term infection by pathogens involves important genetic adaptations. ...
With the exception of intensively studied viral infections such as HIV/AIDs, little is known about the extent to which the clonal expansion …
11 results