Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial.
Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN.
Van Hove JLK, et al. Among authors: spector eb.
J Inherit Metab Dis. 2019 May;42(3):424-437. doi: 10.1002/jimd.12085. Epub 2019 Apr 11.
J Inherit Metab Dis. 2019.
PMID: 30873612
Clinical Trial.
STUDY OBJECTIVE: A phase 1/2 clinical trial was performed in individuals with cystathionine beta synthase (CBS) deficient homocystinuria with aims to: (a) assess pharmacokinetics and safety of taurine therapy, (b) evaluate oxidative stress, inflammation, and vascular function in …
STUDY OBJECTIVE: A phase 1/2 clinical trial was performed in individuals with cystathionine beta synthase (CBS) deficient homocystinuria wit …