Spine degeneration in a murine model of chronic human tobacco smokers.
Wang D, Nasto LA, Roughley P, Leme AS, Houghton AM, Usas A, Sowa G, Lee J, Niedernhofer L, Shapiro S, Kang J, Vo N.
Wang D, et al. Among authors: sowa g.
Osteoarthritis Cartilage. 2012 Aug;20(8):896-905. doi: 10.1016/j.joca.2012.04.010. Epub 2012 Apr 21.
Osteoarthritis Cartilage. 2012.
PMID: 22531458
Free PMC article.
METHODS: Three month old C57BL/6 mice were exposed to tobacco smoke by direct inhalation (4 cigarettes/day, 5 days/week for 6 months) to model long-term smoking in humans. Total disc proteoglycan (PG) content [1,9-dimethylmethylene blue (DMMB) assay], aggrecan proteolysis …
METHODS: Three month old C57BL/6 mice were exposed to tobacco smoke by direct inhalation (4 cigarettes/day, 5 days/week for 6 months) to mod …