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CFTR modulator theratyping: Current status, gaps and future directions.
J Cyst Fibros. 2019 Jan;18(1):22-34. doi: 10.1016/j.jcf.2018.05.004. Epub 2018 Jun 20.
J Cyst Fibros. 2019.
PMID: 29934203
Free PMC article.
Review.
The theme of the workshop was centered on CFTR theratyping, a term that encompasses the use of CFTR modulators to define defects in CFTR in vitro, with application to both common and rare CFTR variants. ...
The theme of the workshop was centered on CFTR theratyping, a term that encompasses the use of CFTR modulators to define defects in C …
SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution.
Plyler ZE, Hill AE, McAtee CW, Cui X, Moseley LA, Sorscher EJ.
Plyler ZE, et al. Among authors: sorscher ej.
Genome Biol Evol. 2015 Aug 6;7(9):2506-19. doi: 10.1093/gbe/evv150.
Genome Biol Evol. 2015.
PMID: 26253317
Free PMC article.
The findings provide insight regarding SNP contextual bias and eukaryotic codon usage as strategies that favor long-term exonic stability. The study also furnishes new information concerning rates of murine genomic evolution and features of DNA mutagenesis (at the time of …
The findings provide insight regarding SNP contextual bias and eukaryotic codon usage as strategies that favor long-term exonic stabi …
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Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis.
Eubanks V, Koppersmith N, Wooldridge N, Clancy JP, Lyrene R, Arani RB, Lee J, Moldawer L, Atchison J, Sorscher EJ, Makris CM.
Eubanks V, et al. Among authors: sorscher ej.
J Pediatr. 2002 Apr;140(4):439-44. doi: 10.1067/mpd.2002.121936.
J Pediatr. 2002.
PMID: 12006958
Clinical Trial.
Reversible adrenal suppression was observed in the majority of patients who received megestrol acetate. CONCLUSIONS: Short-term use of megestrol acetate results in significant weight gain and improved pulmonary function in malnourished subjects with CF. ...
Reversible adrenal suppression was observed in the majority of patients who received megestrol acetate. CONCLUSIONS: Short-term use o …
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Components of human papillomavirus that activate transcription and support plasmid replication in human airway cells.
Gadi VK, Zou N, Liu JS, Cheng S, Broker TR, Sorscher EJ, Chow LT.
Gadi VK, et al. Among authors: sorscher ej.
Am J Respir Cell Mol Biol. 1999 May;20(5):1001-6. doi: 10.1165/ajrcmb.20.5.3479.
Am J Respir Cell Mol Biol. 1999.
PMID: 10226070
Human papillomaviruses (HPVs) such as types 6 and 11 can establish lifelong infections in airway epithelial cells in patients, and long-term infection can lead to pulmonary involvement and death. The mechanisms underlying this persistence depend on both the transcriptional …
Human papillomaviruses (HPVs) such as types 6 and 11 can establish lifelong infections in airway epithelial cells in patients, and long-t …
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