Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

27 results

Filters applied: . Clear all
Page 1
mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory.
Sharma V, Oliveira MM, Sood R, Khlaifia A, Lou D, Hooshmandi M, Hung TY, Mahmood N, Reeves M, Ho-Tieng D, Cohen N, Cheng PC, Rahim MMA, Prager-Khoutorsky M, Kaufman RJ, Rosenblum K, Lacaille JC, Khoutorsky A, Klann E, Sonenberg N. Sharma V, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2308671120. doi: 10.1073/pnas.2308671120. Epub 2023 Nov 28. Proc Natl Acad Sci U S A. 2023. PMID: 38015848
Activation of neuronal protein synthesis upon learning is critical for the formation of long-term memory. Here, we report that learning in the contextual fear conditioning paradigm engenders a decrease in eIF2alpha (eukaryotic translation initiation factor 2) phosphorylati …
Activation of neuronal protein synthesis upon learning is critical for the formation of long-term memory. Here, we report that learni …
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
Wiebe S, Huang Z, Ladak RJ, Skalecka A, Cagnetta R, Lacaille JC, Aguilar-Valles A, Sonenberg N. Wiebe S, et al. Among authors: sonenberg n. Mol Brain. 2023 Jan 18;16(1):9. doi: 10.1186/s13041-023-00995-2. Mol Brain. 2023. PMID: 36650535 Free PMC article.
Similarly, long-term contextual fear memory was not altered in Gad2-directed 4EHP knockout mice (4EHP-cKO(inh)). However, when subjected to a short-term T-maze working memory task, both mouse models exhibited impaired cognition. ...
Similarly, long-term contextual fear memory was not altered in Gad2-directed 4EHP knockout mice (4EHP-cKO(inh)). However, when subjec …
Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation.
Saviuk N, Chong Y, Wang P, Bermudez S, Zhao Z, Bhaskaran AA, Bowie D, Sonenberg N, Cooper E, Haghighi AP. Saviuk N, et al. Among authors: sonenberg n. Cell Rep. 2022 Jun 7;39(10):110911. doi: 10.1016/j.celrep.2022.110911. Cell Rep. 2022. PMID: 35675781 Free article.
We show that genetic removal of 4E-BP, a translational suppressor and target of mammalian target of rapamycin complex 1, results in a striking change in cerebellar synaptic plasticity. We find that cerebellar long-term depression (LTD) at parallel fiber-Purkinje cell synap …
We show that genetic removal of 4E-BP, a translational suppressor and target of mammalian target of rapamycin complex 1, results in a striki …
High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors.
García A, Maldonado G, González JL, Svitkin Y, Cantú D, García-Carrancá A, Sonenberg N, Hernández G. García A, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2108359118. doi: 10.1073/pnas.2108359118. Proc Natl Acad Sci U S A. 2021. PMID: 34615711 Free PMC article.
We show that the translation of HPV-18 E6 cistron is regulated by the motif ACCaugGCGCG(C/A)UUU surrounding the AUG start codon, which we term Translation Initiation of Leaderless mRNAs (TILM). This motif is conserved in all HPV types of the phylogenetically coherent group …
We show that the translation of HPV-18 E6 cistron is regulated by the motif ACCaugGCGCG(C/A)UUU surrounding the AUG start codon, which we …
eIF2α controls memory consolidation via excitatory and somatostatin neurons.
Sharma V, Sood R, Khlaifia A, Eslamizade MJ, Hung TY, Lou D, Asgarihafshejani A, Lalzar M, Kiniry SJ, Stokes MP, Cohen N, Nelson AJ, Abell K, Possemato AP, Gal-Ben-Ari S, Truong VT, Wang P, Yiannakas A, Saffarzadeh F, Cuello AC, Nader K, Kaufman RJ, Costa-Mattioli M, Baranov PV, Quintana A, Sanz E, Khoutorsky A, Lacaille JC, Rosenblum K, Sonenberg N. Sharma V, et al. Among authors: sonenberg n. Nature. 2020 Oct;586(7829):412-416. doi: 10.1038/s41586-020-2805-8. Epub 2020 Oct 7. Nature. 2020. PMID: 33029011 Free PMC article.
An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory(1-4). The regulation of proteostasis is a critical and rate-limiting step in the consolidation of new memories(5-10). ...Phosphorylation of the alp …
An important tenet of learning and memory is the notion of a molecular switch that promotes the formation of long-term memory(1-4). T …
Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs.
Maity S, Rah S, Sonenberg N, Gkogkas CG, Nguyen PV. Maity S, et al. Among authors: sonenberg n. Learn Mem. 2015 Sep 15;22(10):499-508. doi: 10.1101/lm.039222.115. Print 2015 Oct. Learn Mem. 2015. PMID: 26373828 Free PMC article.
Previous studies demonstrated that a beta-adrenergic receptor agonist, isoproterenol, can modify the threshold for long-term potentiation (LTP), a putative cellular mechanism for learning and memory, in a process known as "metaplasticity." ...
Previous studies demonstrated that a beta-adrenergic receptor agonist, isoproterenol, can modify the threshold for long-term potentia …
Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.
Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N. Aguilar-Valles A, et al. Among authors: sonenberg n. J Neurosci. 2015 Aug 5;35(31):11125-32. doi: 10.1523/JNEUROSCI.4615-14.2015. J Neurosci. 2015. PMID: 26245973 Free PMC article.
We investigated the potential reversal of autistic-like phenotypes in Eif4ebp2(-/-) mice by using antagonists of mGluR1 (JNJ16259685) or mGluR5 (fenobam). Augmented hippocampal mGluR-induced long-term depression (LTD; or chemically induced mGluR-LTD) in Eif4ebp2(-/-) mice …
We investigated the potential reversal of autistic-like phenotypes in Eif4ebp2(-/-) mice by using antagonists of mGluR1 (JNJ16259685) or mGl …
Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.
Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R, Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N. Khoutorsky A, et al. Among authors: sonenberg n. Neuron. 2013 Apr 24;78(2):298-311. doi: 10.1016/j.neuron.2013.02.025. Neuron. 2013. PMID: 23622065 Free article.
Paip2a knockout mice exhibit a lowered threshold for the induction of sustained long-term potentiation and an enhancement of long-term memory after weak training. ...
Paip2a knockout mice exhibit a lowered threshold for the induction of sustained long-term potentiation and an enhancement of long- …
Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory.
Stern E, Chinnakkaruppan A, David O, Sonenberg N, Rosenblum K. Stern E, et al. Among authors: sonenberg n. J Neurosci. 2013 Feb 6;33(6):2517-25. doi: 10.1523/JNEUROSCI.2322-12.2013. J Neurosci. 2013. PMID: 23392680 Free PMC article.
Cognitive enhancement can be achieved by using psycho-stimulants, such as caffeine or nicotine, but very little is known about drugs that can enhance the consolidation phase of memories in the cortex, the brain structure considered to store, at least partially, long-term m …
Cognitive enhancement can be achieved by using psycho-stimulants, such as caffeine or nicotine, but very little is known about drugs that ca …
27 results