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Human MAIT cells inhibit alloreactive T cell responses and protect against acute graft-versus-host disease.
Talvard-Balland N, Lambert M, Chevalier MF, Minet N, Salou M, Tourret M, Bohineust A, Milo I, Parietti V, Yvorra T, Socié G, Lantz O, Caillat-Zucman S. Talvard-Balland N, et al. Among authors: socie g. JCI Insight. 2024 Feb 1;9(5):e166310. doi: 10.1172/jci.insight.166310. JCI Insight. 2024. PMID: 38300704 Free article.
Here, we analyzed the immunosuppressive effect of MAIT cells in an in vitro model of alloreactivity and explored their adoptive transfer in a preclinical xenogeneic GVHD model. We found that MAIT cells, whether freshly purified or short-term expanded, dose-dependently inhi …
Here, we analyzed the immunosuppressive effect of MAIT cells in an in vitro model of alloreactivity and explored their adoptive transfer in …
Complex karyotype but not other cytogenetic abnormalities is associated with worse posttransplant survival of patients with nucleophosmin 1-mutated acute myeloid leukemia: A study from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party.
Moukalled N, Labopin M, Versluis J, Socié G, Blaise D, Salmenniemi U, Rambaldi A, Gedde-Dahl T, Tholouli E, Kröger N, Bourhis JH, Von Dem Borne P, Daguindau E, Forcade E, Nagler A, Esteve J, Ciceri F, Bazarbachi A, Mohty M. Moukalled N, et al. Among authors: socie g. Am J Hematol. 2024 Mar;99(3):360-369. doi: 10.1002/ajh.27187. Epub 2024 Jan 2. Am J Hematol. 2024. PMID: 38165072
Nevertheless, even for this subgroup, a significant proportion of patients can achieve long-term posttransplant survival....
Nevertheless, even for this subgroup, a significant proportion of patients can achieve long-term posttransplant survival....
Thiotepa-busulfan-fludarabine Compared to Treosulfan-based Conditioning for Haploidentical Transplant With Posttransplant Cyclophosphamide in Patients With Acute Myeloid Leukemia in Remission: A Study From the Acute Leukemia Working Party of the EBMT.
Saraceni F, Labopin M, Raiola AM, Blaise D, Reményi P, Sorà F, Pavlu J, Bramanti S, Busca A, Berceanu A, Battipaglia G, Visani G, Sociè G, Bug G, Micò C, La Nasa G, Musso M, Olivieri A, Spyridonidis A, Savani B, Ciceri F, Nagler A, Mohty M. Saraceni F, et al. Among authors: socie g. Hemasphere. 2023 Sep 20;7(10):e952. doi: 10.1097/HS9.0000000000000952. eCollection 2023 Oct. Hemasphere. 2023. PMID: 37746158 Free PMC article.
Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria.
Gurnari C, Pagliuca S, Prata PH, Galimard JE, Catto LFB, Larcher L, Sebert M, Allain V, Patel BJ, Durmaz A, Pinto AL, Inacio MCB, Hernandez L, Dhedin N, Caillat-Zucman S, Clappier E, Sicre de Fontbrune F, Voso MT, Visconte V, Peffault de Latour R, Soulier J, Calado RT, Socié G, Maciejewski JP. Gurnari C, et al. Among authors: socie g. J Clin Oncol. 2023 Jan 1;41(1):132-142. doi: 10.1200/JCO.22.00710. Epub 2022 Sep 2. J Clin Oncol. 2023. PMID: 36054881 Free PMC article.
PURPOSE: Secondary myeloid neoplasms (sMNs) remain the most serious long-term complications in patients with aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH). ...
PURPOSE: Secondary myeloid neoplasms (sMNs) remain the most serious long-term complications in patients with aplastic anemia (AA) and …
Azithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation.
Vallet N, Le Grand S, Bondeelle L, Hoareau B, Corneau A, Bouteiller D, Tournier S, Derivry L, Bohineust A, Tourret M, Gibert D, Mayeur E, Itzykson R, Pacchiardi K, Ingram B, Cassonnet S, Lepage P, Peffault de Latour R, Socié G, Bergeron A, Michonneau D. Vallet N, et al. Among authors: socie g. Blood. 2022 Dec 8;140(23):2500-2513. doi: 10.1182/blood.2022016926. Blood. 2022. PMID: 35984904 Free article. Clinical Trial.
These results highlight that azithromycin directly affects immune cells that favor relapse, which raises caution about long-term use of azithromycin treatment in patients at high risk of malignancies. ...
These results highlight that azithromycin directly affects immune cells that favor relapse, which raises caution about long-term use …
Long-Term Outcomes After Transplantation for Acute Myelogenous Leukemia.
Socie G. Socie G. J Clin Oncol. 2022 Oct 1;40(28):3235-3238. doi: 10.1200/JCO.22.01177. Epub 2022 Aug 5. J Clin Oncol. 2022. PMID: 35930761 Review.
Improvement in transplantation strategies, supportive care, and increased donor source availability led to increased numbers of long-term survivors after HSCT. In the accompanying paper of this ground rounds, Armenian and coworkers analyzed the burden of late complications …
Improvement in transplantation strategies, supportive care, and increased donor source availability led to increased numbers of long-term …
Life expectancy and burden of late complications after reduced intensity conditioning allogeneic transplantation.
Del Galy AS, Rousseau A, Capes A, Michonneau D, Robin M, de Fontbrune FS, Xhaard A, Frieri C, Adès L, Raffoux E, Himberlin C, Baudet M, Peffault de Latour R, Socié G. Del Galy AS, et al. Among authors: socie g. Bone Marrow Transplant. 2022 Sep;57(9):1365-1372. doi: 10.1038/s41409-022-01715-5. Epub 2022 Jun 2. Bone Marrow Transplant. 2022. PMID: 35654824
In conclusion, with life expectancy rate of 70%, late survivors after RIC warrants long-term follow-up and active intervention on averting cardiovascular disease and screening cancers....
In conclusion, with life expectancy rate of 70%, late survivors after RIC warrants long-term follow-up and active intervention on ave …
Treosulfan compared with reduced-intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial.
Beelen DW, Stelljes M, Reményi P, Wagner-Drouet EM, Dreger P, Bethge W, Ciceri F, Stölzel F, Junghanß C, Labussiere-Wallet H, Schaefer-Eckart K, Grigoleit GU, Scheid C, Patriarca F, Rambaldi A, Niederwieser D, Hilgendorf I, Russo D, Socié G, Holler E, Glass B, Casper J, Wulf G, Basara N, Bieniaszewska M, Stuhler G, Verbeek M, La Rocca U, Finke J, Benedetti F, Pichlmeier U, Klein A, Baumgart J, Markiewicz M. Beelen DW, et al. Among authors: socie g. Am J Hematol. 2022 Aug;97(8):1023-1034. doi: 10.1002/ajh.26620. Epub 2022 Jun 8. Am J Hematol. 2022. PMID: 35617104 Free article. Clinical Trial.
Here, the final study results and pre-specified subgroup analyses of all 570 randomized patients with completed longer-term follow-up are presented. Patients presenting HCT-specific comorbidity index >2 or aged 50 years were randomly assigned (1:1) to intravenous (IV) f …
Here, the final study results and pre-specified subgroup analyses of all 570 randomized patients with completed longer-term follow-up …
Metabolic syndrome and cardiovascular disease after haematopoietic cell transplantation (HCT) in adults: an EBMT cross-sectional non-interventional study.
Greenfield DM, Salooja N, Peczynski C, van der Werf S, Schoemans H, Hill K, Cortelezzi A, Lupo-Stangellini M, Özkurt ZN, Arat M, Metzner B, Turlure P, Rovo A, Socié G, Mohty M, Nagler A, Kröger N, Dreger P, Labopin M, Han TS, Tichelli A, Duarte R, Basak G, Snowden JA. Greenfield DM, et al. Among authors: socie g. Bone Marrow Transplant. 2021 Nov;56(11):2820-2825. doi: 10.1038/s41409-021-01414-7. Epub 2021 Jul 17. Bone Marrow Transplant. 2021. PMID: 34274955 Free PMC article.
Screening for and management of MetS should be integrated within routine HCT long-term follow-up care for both allogeneic and autologous HCT survivors. ...
Screening for and management of MetS should be integrated within routine HCT long-term follow-up care for both allogeneic and autolog …
Comparison of long-term outcome for AML patients alive free of disease 2 years after allogeneic hematopoietic cell transplantation with umbilical cord blood versus unrelated donor: a study from the ALWP of the EBMT.
Baron F, Ngoya M, Labopin M, Cornelissen JJ, Ganser A, Forcade E, Sengeloev H, Socié G, Blaise D, Bornhäuser M, Valerius T, Reinhardt HC, Kröger N, Ruggeri A, Nagler A, Mohty M. Baron F, et al. Among authors: socie g. Bone Marrow Transplant. 2021 Nov;56(11):2742-2748. doi: 10.1038/s41409-021-01387-7. Epub 2021 Jul 10. Bone Marrow Transplant. 2021. PMID: 34247199 Free article.
Since cord blood transplantation (CBT) has been associated with high graft-versus-leukemia effects and a low incidence of chronic graft-versus-host disease (GVHD), we hypothesized that long-term outcomes might be better in CBT patients than in those given grafts from unrel …
Since cord blood transplantation (CBT) has been associated with high graft-versus-leukemia effects and a low incidence of chronic graft-vers …
163 results