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Neural Stem Cells Derived from Human Parthenogenetic Stem Cells Engraft and Promote Recovery in a Nonhuman Primate Model of Parkinson's Disease.
Gonzalez R, Garitaonandia I, Poustovoitov M, Abramihina T, McEntire C, Culp B, Attwood J, Noskov A, Christiansen-Weber T, Khater M, Mora-Castilla S, To C, Crain A, Sherman G, Semechkin A, Laurent LC, Elsworth JD, Sladek J, Snyder EY, Redmond DE Jr, Kern RA. Gonzalez R, et al. Among authors: snyder ey. Cell Transplant. 2016 Nov;25(11):1945-1966. doi: 10.3727/096368916X691682. Cell Transplant. 2016. PMID: 27213850 Free article.
We have previously reported that human parthenogenetic stem cell-derived neural stem cells (hpNSCs) successfully engraft, survive long term, and increase brain dopamine (DA) levels in rodent and nonhuman primate models of PD. ...
We have previously reported that human parthenogenetic stem cell-derived neural stem cells (hpNSCs) successfully engraft, survive long te …
Human neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury.
Huang L, Wong S, Snyder EY, Hamblin MH, Lee JP. Huang L, et al. Among authors: snyder ey. Stem Cell Res Ther. 2014 Nov 23;5(6):129. doi: 10.1186/scrt519. Stem Cell Res Ther. 2014. PMID: 25418536 Free PMC article.
In support of this idea, in hNSC-transplanted mice we observed reduced microglial activation, decreased expression of proinflammatory factors (tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, monocyte chemotactic protein-1, macrophage inflammatory protein-1alpha) and ad …
In support of this idea, in hNSC-transplanted mice we observed reduced microglial activation, decreased expression of proinflammatory factor …
Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate target.
Wakeman DR, Redmond DE Jr, Dodiya HB, Sladek JR Jr, Leranth C, Teng YD, Samulski RJ, Snyder EY. Wakeman DR, et al. Among authors: snyder ey. Stem Cells Transl Med. 2014 Jun;3(6):692-701. doi: 10.5966/sctm.2013-0208. Epub 2014 Apr 17. Stem Cells Transl Med. 2014. PMID: 24744393 Free PMC article.
Defining Conditions for Sustaining Epiblast Pluripotence Enables Direct Induction of Clinically-Suitable Human Myocardial Grafts from Biologics-Free Human Embryonic Stem Cells.
Parsons JF, Smotrich DB, Gonzalez R, Snyder EY, Moore DA, Parsons XH. Parsons JF, et al. Among authors: snyder ey. J Clin Exp Cardiolog. 2012 Apr 25;S9:001. doi: 10.4172/2155-9880.s9-001. J Clin Exp Cardiolog. 2012. PMID: 22905333 Free PMC article.
Understanding the requirements for sustaining pluripotentce and self-renewal of hESCs will provide the foundation for de novo derivation and long-term maintenance of biologics-free hESCs under optimal yet well-defined culture conditions from which they can be efficiently d …
Understanding the requirements for sustaining pluripotentce and self-renewal of hESCs will provide the foundation for de novo derivation and …
Three-dimensional scaffolding to investigate neuronal derivatives of human embryonic stem cells.
Soman P, Tobe BTD, Lee JW, Winquist AM, Singec I, Vecchio KS, Snyder EY, Chen S. Soman P, et al. Among authors: snyder ey. Biomed Microdevices. 2012 Oct;14(5):829-838. doi: 10.1007/s10544-012-9662-7. Biomed Microdevices. 2012. PMID: 22767243 Free PMC article.
Future refinements of scaffold structure, size and surface chemistries may facilitate long term experiments and designing clinically applicable bioassays....
Future refinements of scaffold structure, size and surface chemistries may facilitate long term experiments and designing clinically …
Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury.
Obenaus A, Dilmac N, Tone B, Tian HR, Hartman R, Digicaylioglu M, Snyder EY, Ashwal S. Obenaus A, et al. Among authors: snyder ey. Ann Neurol. 2011 Feb;69(2):282-91. doi: 10.1002/ana.22168. Epub 2010 Nov 22. Ann Neurol. 2011. PMID: 21387373 Free PMC article.
To be able to pursue clinical trials in newborns using stem cell therapies it is axiomatic that safety be insured through the long-term real time monitoring of cell fate and activity, particularly with regard to observing unanticipated risks to the developing brain. ...
To be able to pursue clinical trials in newborns using stem cell therapies it is axiomatic that safety be insured through the long-term …
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency.
Gonzalez R, Jennings LL, Knuth M, Orth AP, Klock HE, Ou W, Feuerhelm J, Hull MV, Koesema E, Wang Y, Zhang J, Wu C, Cho CY, Su AI, Batalov S, Chen H, Johnson K, Laffitte B, Nguyen DG, Snyder EY, Schultz PG, Harris JL, Lesley SA. Gonzalez R, et al. Among authors: snyder ey. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3552-7. doi: 10.1073/pnas.0914019107. Epub 2010 Feb 2. Proc Natl Acad Sci U S A. 2010. PMID: 20133595 Free PMC article.
We found that the pigment epithelium-derived factor can promote long-term pluripotent growth of human embryonic stem cells without bFGF or TGFbeta/Activin/Nodal ligand supplementation. ...
We found that the pigment epithelium-derived factor can promote long-term pluripotent growth of human embryonic stem cells without bF …
Long-term multilayer adherent network (MAN) expansion, maintenance, and characterization, chemical and genetic manipulation, and transplantation of human fetal forebrain neural stem cells.
Wakeman DR, Hofmann MR, Redmond DE Jr, Teng YD, Snyder EY. Wakeman DR, et al. Among authors: snyder ey. Curr Protoc Stem Cell Biol. 2009 May;Chapter 2:Unit2D.3. doi: 10.1002/9780470151808.sc02d03s9. Curr Protoc Stem Cell Biol. 2009. PMID: 19455542
In the following unit, we describe a new procedure that we have successfully employed to maintain operationally defined human somatic NSC/NPC from developing fetal, pre-term post-natal, and adult cadaveric forebrain. Specifically, we outline the detailed methodology for in …
In the following unit, we describe a new procedure that we have successfully employed to maintain operationally defined human somatic NSC/NP …
Neuroimaging as a basis for rational stem cell therapy.
Ashwal S, Obenaus A, Snyder EY. Ashwal S, et al. Among authors: snyder ey. Pediatr Neurol. 2009 Mar;40(3):227-36. doi: 10.1016/j.pediatrneurol.2008.09.025. Pediatr Neurol. 2009. PMID: 19218036 Review.
Neonatal global or focal hypoxic-ischemic brain injury remains a frequent and devastating condition, with serious long-term sequelae. An important issue in any neonatal clinical trial of neuroprotective agents relates to developing accurate measures of injury severity and …
Neonatal global or focal hypoxic-ischemic brain injury remains a frequent and devastating condition, with serious long-term sequelae. …
21 results