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Impact of extended Elexacaftor/Tezacaftor/Ivacaftor therapy on the gut microbiome in cystic fibrosis.
Marsh R, Santos CD, Yule A, Dellschaft NS, Hoad CL, Ng C, Major G, Smyth AR, Rivett D, van der Gast C. Marsh R, et al. Among authors: smyth ar. J Cyst Fibros. 2024 May 14:S1569-1993(24)00064-X. doi: 10.1016/j.jcf.2024.05.002. Online ahead of print. J Cyst Fibros. 2024. PMID: 38749891
BACKGROUND: There is a paucity of knowledge on the longer-term effects of CF transmembrane conductance regulator (CFTR) modulator therapies upon the gut microbiome and associated outcomes. ...We recommend future studies use integrated omics approaches within a combination …
BACKGROUND: There is a paucity of knowledge on the longer-term effects of CF transmembrane conductance regulator (CFTR) modulator the …
Why and how should children be protected from the deluge of vaping related media and marketing overexposure?
White D, Bush A, Smyth AR, Bhatt JM. White D, et al. Among authors: smyth ar. Breathe (Sheff). 2023 Dec;19(4):230141. doi: 10.1183/20734735.0141-2023. Epub 2023 Dec 19. Breathe (Sheff). 2023. PMID: 38125806 Free PMC article. Review.
E-liquids used for e-cigarettes contain a wide range of harmful substances, and the clinical consequences of this are now being increasingly demonstrated, such as the rise in cases of e-cigarette- or vaping-associated lung injury. In addition, early use may result in long-term …
E-liquids used for e-cigarettes contain a wide range of harmful substances, and the clinical consequences of this are now being increasingly …
Tezacaftor/Ivacaftor therapy has negligible effects on the cystic fibrosis gut microbiome.
Marsh R, Dos Santos C, Hanson L, Ng C, Major G, Smyth AR, Rivett D, van der Gast C. Marsh R, et al. Among authors: smyth ar. Microbiol Spectr. 2023 Aug 21;11(5):e0117523. doi: 10.1128/spectrum.01175-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 37607068 Free PMC article.
Future longitudinal CFTR modulator studies will investigate more effective CFTR modulators and should use prolonged sampling periods, to determine whether longer-term changes occur in the CF gut microbiome. IMPORTANCE People with cystic fibrosis (pwCF) experience persisten …
Future longitudinal CFTR modulator studies will investigate more effective CFTR modulators and should use prolonged sampling periods, to det …
Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis.
Langton Hewer SC, Smith S, Rowbotham NJ, Yule A, Smyth AR. Langton Hewer SC, et al. Among authors: smyth ar. Cochrane Database Syst Rev. 2023 Jun 2;6(6):CD004197. doi: 10.1002/14651858.CD004197.pub6. Cochrane Database Syst Rev. 2023. PMID: 37268599 Review.
Ciprofloxacin and colistin versus TNS We are uncertain whether there is any difference between groups in eradication of P aeruginosa at up to six months (OR 0.43, 95% CI 0.15 to 1.23; 1 trial, 58 participants) or up to 24 months (OR 0.76, 95% CI 0.24 to 2.42; 1 trial, 47 particip …
Ciprofloxacin and colistin versus TNS We are uncertain whether there is any difference between groups in eradication of P aeruginosa at up t …
Digital technology for monitoring adherence to inhaled therapies in people with cystic fibrosis.
Smith S, Calthorpe R, Herbert S, Smyth AR. Smith S, et al. Among authors: smyth ar. Cochrane Database Syst Rev. 2023 Feb 3;2(2):CD013733. doi: 10.1002/14651858.CD013733.pub2. Cochrane Database Syst Rev. 2023. PMID: 36734528 Free PMC article. Review.
AUTHORS' CONCLUSIONS: Digital monitoring plus tailored support via an online platform probably improves adherence to inhaled therapies and reduces treatment burden (but without a corresponding change in QoL) in the medium term (low- and moderate-certainty evidence). In a s …
AUTHORS' CONCLUSIONS: Digital monitoring plus tailored support via an online platform probably improves adherence to inhaled therapies and r …
Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia.
Calthorpe RJ, Poulter C, Smyth AR, Sharkey D, Bhatt J, Jenkins G, Tatler AL. Calthorpe RJ, et al. Among authors: smyth ar. Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1;324(3):L285-L296. doi: 10.1152/ajplung.00106.2021. Epub 2023 Jan 10. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36625900 Free PMC article. Review.
As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antena …
As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one …
Interventions for the eradication of meticillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis.
Lo DK, Muhlebach MS, Smyth AR. Lo DK, et al. Among authors: smyth ar. Cochrane Database Syst Rev. 2022 Dec 13;12(12):CD009650. doi: 10.1002/14651858.CD009650.pub5. Cochrane Database Syst Rev. 2022. PMID: 36511181 Free PMC article. Review.
However, follow-up at three or six months showed no difference between treatment and control in the proportion of participants remaining MRSA-negative. Moreover, the longer-term clinical consequences - in terms of lung function, mortality and cost of care - remain unclear. …
However, follow-up at three or six months showed no difference between treatment and control in the proportion of participants remaining MRS …
Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis.
Webb K, Zain NMM, Stewart I, Fogarty A, Nash EF, Whitehouse JL, Smyth AR, Lilley AK, Knox A, Williams P, Cámara M, Bruce K, Barr HL. Webb K, et al. Among authors: smyth ar. J Med Microbiol. 2022 Feb;71(2):001481. doi: 10.1099/jmm.0.001481. J Med Microbiol. 2022. PMID: 35113780 Free PMC article.
This is the first study to prospectively investigate viable anaerobic bacteria present in the sputum microbiota and their relationship with long-term outcomes in adults with CF. We performed 16S rRNA analysis using a viability quantitative PCR technique on sputum samples o …
This is the first study to prospectively investigate viable anaerobic bacteria present in the sputum microbiota and their relationship with …
Perspectives of patients, family members, health professionals and the public on the impact of COVID-19 on mental health.
Gardiner E, Baumgart A, Tong A, Elliott JH, Azevedo LC, Bersten A, Cervantes L, Chew DP, Cho Y, Crowe S, Douglas IS, Evangelidis N, Flemyng E, Horby P, Howell M, Lee J, Lorca E, Lynch D, Marshall JC, Gonzalez AM, McKenzie A, Manera K, Mehta S, Mer M, Morris AC, Nseir S, Povoa P, Reid M, Sakr Y, Shen N, Smyth AR, Snelling T, Strippoli GFM, Teixeira-Pinto A, Torres A, Viecelli AK, Webb S, Williamson PR, Woc-Colburn L, Zhang J, Craig JC. Gardiner E, et al. Among authors: smyth ar. J Ment Health. 2022 Aug;31(4):524-533. doi: 10.1080/09638237.2021.2022637. Epub 2022 Jan 4. J Ment Health. 2022. PMID: 34983279
CONCLUSION: We found that the unpredictability of COVID-19, the fear of long-term health consequences, burden of guilt, and suffering in isolation profoundly impacted mental health. ...
CONCLUSION: We found that the unpredictability of COVID-19, the fear of long-term health consequences, burden of guilt, and suffering …
Calcification-driven CO2 emissions exceed "Blue Carbon" sequestration in a carbonate seagrass meadow.
Van Dam BR, Zeller MA, Lopes C, Smyth AR, Böttcher ME, Osburn CL, Zimmerman T, Pröfrock D, Fourqurean JW, Thomas H. Van Dam BR, et al. Among authors: smyth ar. Sci Adv. 2021 Dec 17;7(51):eabj1372. doi: 10.1126/sciadv.abj1372. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910519 Free PMC article.
Long-term "Blue Carbon" burial in seagrass meadows is complicated by other carbon and alkalinity exchanges that shape net carbon sequestration. ...
Long-term "Blue Carbon" burial in seagrass meadows is complicated by other carbon and alkalinity exchanges that shape net carbon sequ …
25 results