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Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole.
Randell RL, Balevic SJ, Greenberg RG, Cohen-Wolkowiez M, Thompson EJ, Venkatachalam S, Smith MJ, Bendel C, Bliss JM, Chaaban H, Chhabra R, Dammann CEL, Downey LC, Hornik C, Hussain N, Laughon MM, Lavery A, Moya F, Saxonhouse M, Sokol GM, Trembath A, Weitkamp J-H, Hornik CP; Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee. Randell RL, et al. Among authors: smith mj. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0153323. doi: 10.1128/aac.01533-23. Epub 2024 Mar 14. Antimicrob Agents Chemother. 2024. PMID: 38477706 Free PMC article.
Using the resulting predictive equation, we estimated plasma metronidazole concentrations (ePlasma) from 399 DBS collected from 122 preterm and term infants [mean (SD): post natal age 16.7 (15.8) days, GA 31.4 (5.1) weeks] from the Antibiotic Safety in Infants with Complic …
Using the resulting predictive equation, we estimated plasma metronidazole concentrations (ePlasma) from 399 DBS collected from 122 preterm …
Effect of vitamin E-enhanced highly cross-linked polyethylene on wear rate and particle debris in anatomic total shoulder arthroplasty: a biomechanical comparison to ultrahigh-molecular-weight polyethylene.
Khan AZ, Maxwell MJ, Parrott RM, Bowler AR, Glass EA, Miller D, Vasconcellos D, Brownhill JR, Austin LS, Cuff DJ, Murthi AM, Smith MJ, Wiater JM, Jawa A. Khan AZ, et al. Among authors: smith mj. J Shoulder Elbow Surg. 2024 Jan 4:S1058-2746(23)00900-X. doi: 10.1016/j.jse.2023.11.016. Online ahead of print. J Shoulder Elbow Surg. 2024. PMID: 38182025
Vitamin E-enhanced polyethylene shows early promise in shoulder arthroplasty components. Long-term clinical and radiographic investigation needs to be performed to verify if these biomechanical wear properties translate to diminished long-term wear, osteolysis, and …
Vitamin E-enhanced polyethylene shows early promise in shoulder arthroplasty components. Long-term clinical and radiographic investig …
Metal profiling in coronary ischemia-reperfusion injury: Implications for KEAP1/NRF2 regulated redox signaling.
Yang F, Smith MJ. Yang F, et al. Among authors: smith mj. Free Radic Biol Med. 2024 Jan;210:158-171. doi: 10.1016/j.freeradbiomed.2023.11.013. Epub 2023 Nov 19. Free Radic Biol Med. 2024. PMID: 37989446 Review.
In view of the unique double-edged characteristics of metals, we aim to bridge the role of metals and NRF2 regulated redox signaling to antioxidant defenses in IR injury, with a long-term aim of informing the design and application of novel therapeutics....
In view of the unique double-edged characteristics of metals, we aim to bridge the role of metals and NRF2 regulated redox signaling to anti …
Optimization of polygenic risk scores in BRCA1/2 pathogenic variant heterozygotes in epithelial ovarian cancer.
Flaum N, Bowes J, Smith MJ, Crosbie EJ, Edmondson R, Lophatananon A, Evans DG. Flaum N, et al. Among authors: smith mj. Genet Med. 2023 Sep;25(9):100898. doi: 10.1016/j.gim.2023.100898. Epub 2023 May 19. Genet Med. 2023. PMID: 37212253 Free article.
The optimized model (parity, age at menarche, menopause, and first full-term pregnancy) estimated AUC values of 0.872 to 0.876 and 21- to 23-fold increase in OR (BRCA1 heterozygotes) and AUC values of 0.857 to 0.867 and 40- to 41-fold increase (BRCA2 heterozygotes). ...
The optimized model (parity, age at menarche, menopause, and first full-term pregnancy) estimated AUC values of 0.872 to 0.876 and 21 …
Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients.
Stensland ZC, Magera CA, Broncucia H, Gomez BD, Rios-Guzman NM, Wells KL, Nicholas CA, Rihanek M, Hunter MJ, Toole KP, Gottlieb PA, Smith MJ. Stensland ZC, et al. Among authors: smith mj. J Exp Med. 2023 Aug 7;220(8):e20221604. doi: 10.1084/jem.20221604. Epub 2023 May 15. J Exp Med. 2023. PMID: 37184563 Free PMC article.
Unsupervised clustering revealed the existence of a highly activated B cell subset we term BND2 that falls within the previously defined anergic BND subset. ...
Unsupervised clustering revealed the existence of a highly activated B cell subset we term BND2 that falls within the previously defi …
Associations between baseline cognitive status and motor outcomes after treadmill training in people with Parkinson's disease: a pilot study.
Amin RM, Phillips JJ, Humbert AT, Cholerton BA, Short VD, Smith MJ, Zabetian CP, Mata IF, Kelly VE. Amin RM, et al. Among authors: smith mj. Disabil Rehabil. 2024 Mar;46(6):1082-1091. doi: 10.1080/09638288.2023.2189318. Epub 2023 Apr 3. Disabil Rehabil. 2024. PMID: 37010072 Clinical Trial.
Response to intervention was assessed by gait speed measured after week 2 (short-term) and week 10 (long-term). RESULTS: Participants (n = 19; 12 PD-NCI, 7 PD-MCI) had a mean (standard deviation) age of 66.5 (6.3) years, disease duration of 8.8 (6.3) years, and MDS- …
Response to intervention was assessed by gait speed measured after week 2 (short-term) and week 10 (long-term). RESULTS: Parti …
Umbilical Cord Blood-Derived Cell Therapy for Perinatal Brain Injury: A Systematic Review & Meta-Analysis of Preclinical Studies.
Nguyen T, Purcell E, Smith MJ, Penny TR, Paton MCB, Zhou L, Jenkin G, Miller SL, McDonald CA, Malhotra A. Nguyen T, et al. Among authors: smith mj. Int J Mol Sci. 2023 Feb 22;24(5):4351. doi: 10.3390/ijms24054351. Int J Mol Sci. 2023. PMID: 36901781 Free PMC article. Review.
Perinatal brain injury is a major contributor to long-term adverse neurodevelopment. There is mounting preclinical evidence for use of umbilical cord blood (UCB)-derived cell therapy as potential treatment. ...
Perinatal brain injury is a major contributor to long-term adverse neurodevelopment. There is mounting preclinical evidence for use o …
Between rules and resistance: moving public health emergency responses beyond fear, racism and greed.
Jackson C, Habibi R, Forman L, Silva DS, Smith MJ. Jackson C, et al. Among authors: smith mj. BMJ Glob Health. 2022 Dec;7(12):e009945. doi: 10.1136/bmjgh-2022-009945. BMJ Glob Health. 2022. PMID: 36593643 Free PMC article. Review.
With a new pandemic treaty and amendments to the WHO's International Health Regulations (IHR) on the near-term horizon, ethics and international law are at a key inflection point in global health governance. ...
With a new pandemic treaty and amendments to the WHO's International Health Regulations (IHR) on the near-term horizon, ethics and in …
Predictive Factors for Failure of Intraarticular Injection in Management of Adhesive Capsulitis of the Shoulder.
Hanish SJ, Resnick ML, Kim HM, Smith MJ. Hanish SJ, et al. Among authors: smith mj. J Clin Med. 2022 Oct 21;11(20):6212. doi: 10.3390/jcm11206212. J Clin Med. 2022. PMID: 36294535 Free PMC article.
Intraarticular (IA) corticosteroid injections have been demonstrated to be an effective management for adhesive capsulitis in both the short- and mid-term. Yet, certain patients fail to improve both subjectively and clinically. ...
Intraarticular (IA) corticosteroid injections have been demonstrated to be an effective management for adhesive capsulitis in both the short …
Chronic tracheostomy care of ventilator-dependent and -independent children: Clinical practice patterns of pediatric respirologists in a publicly funded (Canadian) healthcare system.
St-Laurent A, Zielinski D, Qazi A, AlAwadi A, Almajed A, Adamko DJ, Alabdoulsalam T, Chiang J, Derynck M, Gerdung C, Kam K, Katz SL, MacLusky I, Mehta K, Mateos D, Nguyen TTD, Praud JP, Proulx F, Seear M, Smith MJ, Wensley D, Amin R. St-Laurent A, et al. Among authors: smith mj. Pediatr Pulmonol. 2023 Jan;58(1):140-151. doi: 10.1002/ppul.26171. Epub 2022 Oct 11. Pediatr Pulmonol. 2023. PMID: 36178281
Domains assessed included tracheostomy tube care, caregiver competency and home monitoring, speaking valves, medical management of tracheostomy complications, decannulation, and long-term follow-up. RESULTS: The response rate was 100% (17/17) with all Canadian tertiary car …
Domains assessed included tracheostomy tube care, caregiver competency and home monitoring, speaking valves, medical management of tracheost …
84 results