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Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir SK, Axtman AD. Castano A, et al. Among authors: smith jl. Elife. 2023 Jul 25;12:e88206. doi: 10.7554/eLife.88206. Elife. 2023. PMID: 37490324 Free PMC article.
Further, Cdkl5 knock-out rodents have increased GSK3beta activity and often increased long-term potentiation (LTP). Thus, development of a specific CDKL5 inhibitor must be careful to exclude cross-talk with GSK3beta activity. ...
Further, Cdkl5 knock-out rodents have increased GSK3beta activity and often increased long-term potentiation (LTP). Thus, development …
Improved clinical outcomes in response to a 12-week blended digital and community-based long-COVID-19 rehabilitation programme.
Smith JL, Deighton K, Innes AQ, Holl M, Mould L, Liao Z, Doherty P, Whyte G, King JA, Deniszczyc D, Kelly BM. Smith JL, et al. Front Med (Lausanne). 2023 May 24;10:1149922. doi: 10.3389/fmed.2023.1149922. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37293307 Free PMC article.
This rehabilitation model is well placed to support the NHS (and other healthcare systems worldwide) in its aim of controlling the impacts of COVID-19 and delivering on its long-term plan. CLINICAL TRIAL REGISTRATION: https://www.isrctn.com/ISRCTN14707226, identifier 14707 …
This rehabilitation model is well placed to support the NHS (and other healthcare systems worldwide) in its aim of controlling the impacts o …
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.
Castano A, Silvestre M, Wells CI, Sanderson JL, Ferrer CA, Ong HW, Lang Y, Richardson W, Silvaroli JA, Bashore FM, Smith JL, Genereux IM, Dempster K, Drewry DH, Pabla NS, Bullock AN, Benke TA, Ultanir S, Axtman AD. Castano A, et al. Among authors: smith jl. bioRxiv [Preprint]. 2023 Jun 16:2023.04.24.538049. doi: 10.1101/2023.04.24.538049. bioRxiv. 2023. PMID: 37162893 Free PMC article. Updated. Preprint.
Further, Cdkl5 knock-out rodents have increased GSK3b activity and often increased long-term potentiation (LTP). Thus, development of a specific CDKL5 inhibitor must be careful to exclude cross-talk with GSK3b activity. ...
Further, Cdkl5 knock-out rodents have increased GSK3b activity and often increased long-term potentiation (LTP). Thus, development of …
Utility-value intervention promotes persistence and diversity in STEM.
Asher MW, Harackiewicz JM, Beymer PN, Hecht CA, Lamont LB, Else-Quest NM, Priniski SJ, Thoman DB, Hyde JS, Smith JL. Asher MW, et al. Among authors: smith jl. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2300463120. doi: 10.1073/pnas.2300463120. Epub 2023 May 1. Proc Natl Acad Sci U S A. 2023. PMID: 37126675 Free PMC article. Clinical Trial.
We tested the long-term effects of a utility-value intervention administered in a gateway chemistry course, with the goal of promoting persistence and diversity in STEM. ...
We tested the long-term effects of a utility-value intervention administered in a gateway chemistry course, with the goal of promotin …
Development and Preliminary Evaluation of an Implementation Facilitation Training Program.
Kirchner JE, Dollar KM, Smith JL, Pitcock JA, Curtis ND, Morris KK, Fletcher TL, Topor DR. Kirchner JE, et al. Among authors: smith jl. Implement Res Pract. 2022 Apr 18;3:26334895221087475. doi: 10.1177/26334895221087475. eCollection 2022 Jan-Dec. Implement Res Pract. 2022. PMID: 37091085 Free PMC article.
Further research is needed to examine whether ongoing mentoring helps trainees retain confidence in applying some IF skills over the longer term....
Further research is needed to examine whether ongoing mentoring helps trainees retain confidence in applying some IF skills over the longer …
Addressing the impact of canine distemper spreading on an isolated tiger population in northeast Asia.
Wang D, Smith JLD, Accatino F, Ge J, Wang T. Wang D, et al. Among authors: smith jld. Integr Zool. 2023 Nov;18(6):994-1008. doi: 10.1111/1749-4877.12712. Epub 2023 Mar 21. Integr Zool. 2023. PMID: 36881515
Our key management recommendations for this population underline the importance of reducing CDV threats and expanding tiger occupancy to its former range in China, but re-establishing habitat connectivity to the neighboring population is an important long-term objective... …
Our key management recommendations for this population underline the importance of reducing CDV threats and expanding tiger occupancy to its …
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease.
Erickson MA, Logsdon AF, Rhea EM, Hansen KM, Holden SJ, Banks WA, Smith JL, German C, Farr SA, Morley JE, Weaver RR, Hirsch AJ, Kovac A, Kontsekova E, Baumann KK, Omer MA, Raber J. Erickson MA, et al. Among authors: smith jl. Brain Behav Immun. 2023 Mar;109:251-268. doi: 10.1016/j.bbi.2023.01.010. Epub 2023 Jan 20. Brain Behav Immun. 2023. PMID: 36682515 Free PMC article.
COVID-19 and especially Long COVID are associated with severe CNS symptoms and may place persons at risk to develop long-term cognitive impairments. Here, we show that two non-infective models of SARS-CoV-2 can cross the blood-brain barrier (BBB) and induce neuroinflammati …
COVID-19 and especially Long COVID are associated with severe CNS symptoms and may place persons at risk to develop long-term cogniti …
Hydrocephalus surveillance following CSF diversion: a modified Delphi study.
Hersh DS, Martin JE, Bristol RE, Browd SR, Grant G, Gupta N, Hankinson TC, Jackson EM, Kestle JRW, Krieger MD, Kulkarni AV, Madura CJ, Pindrik J, Pollack IF, Raskin JS, Riva-Cambrin J, Rozzelle CJ, Smith JL, Wellons JC. Hersh DS, et al. Among authors: smith jl. J Neurosurg Pediatr. 2022 Jun 17;30(2):177-187. doi: 10.3171/2022.5.PEDS22116. Print 2022 Aug 1. J Neurosurg Pediatr. 2022. PMID: 35901763
OBJECTIVE: Long-term follow-up is often recommended for patients with hydrocephalus, but the frequency of clinical follow-up, timing and modality of imaging, and duration of surveillance have not been clearly defined. ...
OBJECTIVE: Long-term follow-up is often recommended for patients with hydrocephalus, but the frequency of clinical follow-up, timing …
Association of Dulaglutide Initiation Timing With Treatment Patterns and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus in the United States.
Hoog M, Smith JL, Yu M, Peleshok J, Mody R, Grabner M. Hoog M, et al. Among authors: smith jl. Clin Ther. 2022 Jun;44(6):873-887. doi: 10.1016/j.clinthera.2022.04.005. Epub 2022 May 24. Clin Ther. 2022. PMID: 35618571 Free article.
IMPLICATIONS: Cohorts of dulaglutide therapy initiators, defined by prior OAD use as a proxy of timing of initiation, differed in their baseline characteristics and short-term follow-up outcomes. Earlier dulaglutide therapy initiation was associated with lower mean HbA(1c) …
IMPLICATIONS: Cohorts of dulaglutide therapy initiators, defined by prior OAD use as a proxy of timing of initiation, differed in their base …
A lyophilized colorimetric RT-LAMP test kit for rapid, low-cost, at-home molecular testing of SARS-CoV-2 and other pathogens.
Song X, Coulter FJ, Yang M, Smith JL, Tafesse FG, Messer WB, Reif JH. Song X, et al. Among authors: smith jl. Sci Rep. 2022 Apr 29;12(1):7043. doi: 10.1038/s41598-022-11144-5. Sci Rep. 2022. PMID: 35487969 Free PMC article.

The entire sample-to-answer workflow takes < 60 min, including noninvasive sample collection, one-step RNA preparation, reverse-transcription loop-mediated isothermal amplification (RT-LAMP) in a thermos, and direct visual inspection of a colorimetric test result. To facilitat

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The entire sample-to-answer workflow takes < 60 min, including noninvasive sample collection, one-step RNA preparation, reverse-transcrip

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67 results