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Association of perioperative transfusion of fresh frozen plasma and outcomes after cardiac surgery.
Hinton JV, Xing Z, Fletcher C, Perry LA, Karamesinis A, Shi J, Penny-Dimri JC, Ramson D, Coulson TG, Segal R, Smith JA, Williams-Spence J, Weinberg L, Bellomo R. Hinton JV, et al. Among authors: smith ja. Acta Anaesthesiol Scand. 2024 Mar 11. doi: 10.1111/aas.14406. Online ahead of print. Acta Anaesthesiol Scand. 2024. PMID: 38467589
FFP transfusion was associated with 30-day mortality (odds ratio (OR), 1.41; 99% CI, 1.17-1.71; p < .0001), but not with long-term mortality (hazard ratio (HR), 0.92; 99% CI, 0.85-1.00; p = .007, Holm-Bonferroni alpha = 0.0004). ...

FFP transfusion was associated with 30-day mortality (odds ratio (OR), 1.41; 99% CI, 1.17-1.71; p < .0001), but not with long-term

…
Epigenome-wide association study of long-term psychosocial stress in older adults.
Opsasnick LA, Zhao W, Schmitz LL, Ratliff SM, Faul JD, Zhou X, Needham BL, Smith JA. Opsasnick LA, et al. Among authors: smith ja. Epigenetics. 2024 Dec;19(1):2323907. doi: 10.1080/15592294.2024.2323907. Epub 2024 Mar 3. Epigenetics. 2024. PMID: 38431869 Free PMC article.
Long-term psychosocial stress is strongly associated with negative physical and mental health outcomes, as well as adverse health behaviours; however, little is known about the role that stress plays on the epigenome. ...
Long-term psychosocial stress is strongly associated with negative physical and mental health outcomes, as well as adverse health beh …
Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial.
Wu Z, Spencer LG, Banya W, Westoby J, Tudor VA, Rivera-Ortega P, Chaudhuri N, Jakupovic I, Patel B, Thillai M, West A, Wijsenbeek M, Maher TM, Smith JA, Molyneaux PL. Wu Z, et al. Among authors: smith ja. Lancet Respir Med. 2024 Apr;12(4):273-280. doi: 10.1016/S2213-2600(23)00432-0. Epub 2024 Jan 15. Lancet Respir Med. 2024. PMID: 38237620 Free article. Clinical Trial.
Morphine shows promise as an effective treatment to palliate cough in patients with idiopathic pulmonary fibrosis, and longer term studies should be the focus of future research. FUNDING: The Jon Moulton Charity Trust....
Morphine shows promise as an effective treatment to palliate cough in patients with idiopathic pulmonary fibrosis, and longer term st …
Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease.
Li Y, Wang M, Liu X, Rong J, Miller PE, Joehanes R, Huan T, Guo X, Rotter JI, Smith JA, Yu B, Nayor M, Levy D, Liu C, Ma J. Li Y, et al. Among authors: smith ja. BMC Med. 2023 Nov 16;21(1):443. doi: 10.1186/s12916-023-03149-2. BMC Med. 2023. PMID: 37968697 Free PMC article.
BACKGROUND: Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alcohol drinking and cardiovascular disease (CVD), we investigated circulating metabolites associated with long-term alcohol consumption …
BACKGROUND: Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alco …
Survival Benefit of Multiple Arterial Revascularization With and Without Supplementary Saphenous Vein Graft.
Ren J, Tian DH, Gaudino M, Fremes S, Reid CM, Vallely M, Smith JA, Srivastav N, Royse C, Royse A. Ren J, et al. Among authors: smith ja. J Am Heart Assoc. 2023 Nov 10;12(22):e031986. doi: 10.1161/JAHA.123.031986. Online ahead of print. J Am Heart Assoc. 2023. PMID: 37947115 Free PMC article.
Conclusions Multiple arterial grafting has significantly improved long-term survival compared with single arterial grafting. A further incremental survival benefit exists when no SVG is used....
Conclusions Multiple arterial grafting has significantly improved long-term survival compared with single arterial grafting. A furthe …
Propranolol treatment during repetitive mild traumatic brain injuries induces transcriptomic changes in the bone marrow of mice.
Smith JA, Nguyen T, Davis BC, Lahiri DK, Hato T, Obukhov AG, White FA. Smith JA, et al. Front Neurosci. 2023 Sep 12;17:1219941. doi: 10.3389/fnins.2023.1219941. eCollection 2023. Front Neurosci. 2023. PMID: 37817806 Free PMC article.
INTRODUCTION: There are 1.5 million new mild traumatic brain injuries (mTBI) annually in the US, with many of the injured experiencing long-term consequences lasting months after the injury. Although the post injury mechanisms are not well understood, current knowledge ind …
INTRODUCTION: There are 1.5 million new mild traumatic brain injuries (mTBI) annually in the US, with many of the injured experiencing long- …
Impact of persistent PSA after salvage radical prostatectomy: a multicenter study.
Preisser F, Incesu RB, Rajwa P, Chlosta M, Nohe F, Ahmed M, Abreu AL, Cacciamani G, Ribeiro L, Kretschmer A, Westhofen T, Smith JA, Steuber T, Calleris G, Raskin Y, Gontero P, Joniau S, Sanchez-Salas R, Shariat SF, Gill I, Karnes RJ, Cathcart P, Van Der Poel H, Marra G, Tilki D. Preisser F, et al. Among authors: smith ja. Prostate Cancer Prostatic Dis. 2023 Oct 6. doi: 10.1038/s41391-023-00728-5. Online ahead of print. Prostate Cancer Prostatic Dis. 2023. PMID: 37803241
To investigate the impact of persistent PSA after salvage RP on long-term oncologic outcomes. MATERIAL AND METHODS: Patients who underwent salvage RP for recurrent prostate cancer between 2000 and 2021 were identified from twelve high-volume centers. ...
To investigate the impact of persistent PSA after salvage RP on long-term oncologic outcomes. MATERIAL AND METHODS: Patients who unde …
Female and male patients have similar outcomes after transcarotid artery revascularization in prospective trials.
Smith JA, Chung JM, Schneider PA, Kwolek CJ, Arko FR, Henao S, Titus J, DiMuzio P, Roddy S, Farber MA, Kashyap VS; ROADSTER Trial Investigators. Smith JA, et al. J Vasc Surg. 2024 Jan;79(1):81-87.e1. doi: 10.1016/j.jvs.2023.09.007. Epub 2023 Sep 15. J Vasc Surg. 2024. PMID: 37716579
Female patients were more often <65 years old (20.6% vs 15%) or 80 years old (22.6% vs 20.2%) compared with males, and were more often of Black/African American ethnicity (7.5% vs 4.3%). There were no differences by sex in term of comorbidities, current or prior smoking …
Female patients were more often <65 years old (20.6% vs 15%) or 80 years old (22.6% vs 20.2%) compared with males, and were more often of …
Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization.
Nguyen T, Nguyen N, Cochran AG, Smith JA, Al-Juboori M, Brumett A, Saxena S, Talley S, Campbell EM, Obukhov AG, White FA. Nguyen T, et al. Among authors: smith ja. J Neuroinflammation. 2023 Aug 27;20(1):196. doi: 10.1186/s12974-023-02871-1. J Neuroinflammation. 2023. PMID: 37635235 Free PMC article.
Despite extensive studies investigating the underlying mechanisms of mTBI-associated chronic pain, the role of inflammation in long-term pain after mTBIs is not fully elucidated. Given the shifting dynamics of inflammation, it is important to understand the spatial-longitu …
Despite extensive studies investigating the underlying mechanisms of mTBI-associated chronic pain, the role of inflammation in long-term …
Weekend effect in emergency laparotomy: a propensity score-matched analysis.
Sylivris A, Ramson DM, Penny-Dimri JC, Liu Z, Perry LA, Au J, Yang Z, Park B, Pitesa R, Singh S, Smith JA, Taneja A, Eglinton T, Welsh F, Koea J, MacCormick AD, Barazanchi A, Hill AG. Sylivris A, et al. Among authors: smith ja. ANZ J Surg. 2023 Jul-Aug;93(7-8):1806-1810. doi: 10.1111/ans.18595. Epub 2023 Jul 7. ANZ J Surg. 2023. PMID: 37420316
BACKGROUND: The 'weekend effect' is the term given to the observed discrepancy regarding patient care and outcomes on weekends compared to weekdays. ...
BACKGROUND: The 'weekend effect' is the term given to the observed discrepancy regarding patient care and outcomes on weekends compar …
204 results