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Cdk12 maintains the integrity of adult axons by suppressing actin remodeling.
Townsend LN, Clarke H, Maddison D, Jones KM, Amadio L, Jefferson A, Chughtai U, Bis DM, Züchner S, Allen ND, Van der Goes van Naters W, Peters OM, Smith GA. Townsend LN, et al. Among authors: smith ga. Cell Death Discov. 2023 Sep 20;9(1):348. doi: 10.1038/s41420-023-01642-4. Cell Death Discov. 2023. PMID: 37730761 Free PMC article.
We demonstrate that Cdk12 is also an essential gene for long-term neuronal survival and loss of this gene causes age-dependent neurodegeneration. ...
We demonstrate that Cdk12 is also an essential gene for long-term neuronal survival and loss of this gene causes age-dependent neurod …
Short-term impacts of all-driver handheld cellphone bans on high-schoolers' texting while driving: quasi-experimental analyses of Illinois and Georgia.
Benedetti MH, Schwebel DC, Lu B, Rudisill TM, Smith GA, Zhu M. Benedetti MH, et al. Among authors: smith ga. Accid Anal Prev. 2023 May;184:107014. doi: 10.1016/j.aap.2023.107014. Epub 2023 Feb 27. Accid Anal Prev. 2023. PMID: 36858001
We hypothesize that recent policy changes in Georgia and Illinois from teen cellphone bans with all-driver texting bans to all-driver handheld phone bans yielded short-term reductions in teen texting while driving. We analyzed Youth Risk Behavior Surveys in Georgia, Illino …
We hypothesize that recent policy changes in Georgia and Illinois from teen cellphone bans with all-driver texting bans to all-driver handhe …
Clonal Imaging of Mitochondria in the Dissected Fly Wing.
Maddison DC, Mattedi F, Vagnoni A, Smith GA. Maddison DC, et al. Among authors: smith ga. Cold Spring Harb Protoc. 2023 Feb 1;2023(2):100-105. doi: 10.1101/pdb.prot108051. Cold Spring Harb Protoc. 2023. PMID: 36180212
Mitochondria are essential for long-term neuronal function and survival. They are maintained in neurons, including long axonal stretches, through dynamic processes such as fission, fusion, biogenesis, and mitophagy. ...Therefore, an understanding of the axonal mitochondria …
Mitochondria are essential for long-term neuronal function and survival. They are maintained in neurons, including long axonal stretc …
Clinical Utility of Routine Postoperative Imaging in Spinal Fusion Surgery: A Systematic Review.
Shost MD, Jella TK, Ronald AA, Herring EZ, Sajatovic M, Smith GA. Shost MD, et al. Among authors: smith ga. World Neurosurg. 2022 Nov;167:222-228.e1. doi: 10.1016/j.wneu.2022.07.091. Epub 2022 Jul 31. World Neurosurg. 2022. PMID: 35922007 Review.
CONCLUSIONS: Our analysis found that routine imaging after spinal fusion surgery had no direct benefit on clinical management. The utility of baseline imaging for long-term comparison and medicolegal concerns were not studied and remain up to the provider's judgment. ...
CONCLUSIONS: Our analysis found that routine imaging after spinal fusion surgery had no direct benefit on clinical management. The utility o …
A nod and a Wnk to axon branching and destruction.
Peters OM, Smith GA. Peters OM, et al. Among authors: smith ga. Neuron. 2021 Sep 15;109(18):2799-2802. doi: 10.1016/j.neuron.2021.08.027. Neuron. 2021. PMID: 34534451 Free article.
In this issue of Neuron, Izadifar et al. (2021) have identified a conserved molecule Wnk as a key regulator in both developmental axon branching and long-term survival of neurons, characterizing its interplay with axon destruction genes including Sarm. ...
In this issue of Neuron, Izadifar et al. (2021) have identified a conserved molecule Wnk as a key regulator in both developmental axon branc …
Frailty Is Associated With Decreased Time Spent at Home After Critical Illness: A Population-Based Study.
Hendin A, Tanuseputro P, McIsaac DI, Hsu AT, Smith GA, Begum J, Thompson LH, Stelfox HT, Reardon P, Herritt B, Chaudhuri D, Rosenberg E, Kyeremanteng K. Hendin A, et al. Among authors: smith ga. J Intensive Care Med. 2021 Aug;36(8):937-944. doi: 10.1177/0885066620939055. Epub 2020 Jul 15. J Intensive Care Med. 2021. PMID: 32666869
Secondary outcomes included mortality, health care-associated costs, ICU interventions, long-term care admissions, and hospital readmissions. RESULTS: Frail patients spent significantly fewer days at home within 1 year of index hospitalization (mean 159 days vs 223 days in …
Secondary outcomes included mortality, health care-associated costs, ICU interventions, long-term care admissions, and hospital readm …
How Often, Where, and by Which Specialty Do Long-Term Care Home Residents Receive Specialist Physician Care? A Retrospective Cohort Study.
Shaver NS, Lapenskie J, Smith GA, Hsu AT, Liddy C, Tanuseputro P. Shaver NS, et al. Among authors: smith ga. J Appl Gerontol. 2021 Aug;40(8):837-846. doi: 10.1177/0733464819901255. Epub 2020 Feb 6. J Appl Gerontol. 2021. PMID: 32028821
This retrospective cohort study describes the rates, location, and determinants of specialist physician visits among 257,216 long-term care (LTC) residents across 648 LTC homes in Ontario, Canada, between 2007 and 2016. ...
This retrospective cohort study describes the rates, location, and determinants of specialist physician visits among 257,216 long-term …
Incidence and outcomes of major trauma in New Zealand: findings from a feasibility study of New Zealand's first national trauma registry.
Czuba KJ, Kersten P, Anstiss D, Kayes NM, Gabbe BJ, Civil I, Kool B, Terry G, Smith GA, Rohan M, Vandal AC, Siegert RJ. Czuba KJ, et al. Among authors: smith ga. N Z Med J. 2019 May 3;132(1494):26-40. N Z Med J. 2019. PMID: 31048822
AIMS: The aim of the study was to pilot the feasibility of long-term outcomes data collection from adult major trauma survivors in New Zealand. This initial paper aims to characterise the New Zealand major trauma population in terms of long-term disability and funct …
AIMS: The aim of the study was to pilot the feasibility of long-term outcomes data collection from adult major trauma survivors in Ne …
Rare Neurosurgical Complications of Epidural Injections: An 8-Yr Single-Institution Experience.
Smith GA, Pace J, Strohl M, Kaul A, Hayek S, Miller JP. Smith GA, et al. Oper Neurosurg (Hagerstown). 2017 Apr 1;13(2):271-279. doi: 10.1093/ons/opw014. Oper Neurosurg (Hagerstown). 2017. PMID: 28927205
Six patients who developed epidural hematoma had been managed in accordance with current guidelines, either after prolonged cessation of anticoagulation (n = 3) or taking only aspirin (n = 3); all were decompressed promptly with good long-term outcome. All infections were …
Six patients who developed epidural hematoma had been managed in accordance with current guidelines, either after prolonged cessation of ant …
Rare Complications of Cervical Spine Surgery: Pseudomeningocoele.
Ailon T, Smith JS, Nassr A, Smith ZA, Hsu WK, Fehlings MG, Fish DE, Wang JC, Hilibrand AS, Mummaneni PV, Chou D, Sasso RC, Traynelis VC, Arnold PM, Mroz TE, Buser Z, Lord EL, Massicotte EM, Sebastian AS, Than KD, Steinmetz MP, Smith GA, Pace J, Corriveau M, Lee S, Riew KD, Shaffrey C. Ailon T, et al. Among authors: smith ga. Global Spine J. 2017 Apr;7(1 Suppl):109S-114S. doi: 10.1177/2192568216687769. Epub 2017 Apr 1. Global Spine J. 2017. PMID: 28451481 Free PMC article.
Approximately half of PMCs required surgery and all ultimately resolved without residual neurologic or other long-term effects....
Approximately half of PMCs required surgery and all ultimately resolved without residual neurologic or other long-term effects....
23 results