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Increased Risk of Cryptogenic Stroke Associated with Patent Foramen Ovale in Young Adults.
Knupp AJ, Smith DA. Knupp AJ, et al. Among authors: smith da. Cureus. 2024 Feb 3;16(2):e53502. doi: 10.7759/cureus.53502. eCollection 2024 Feb. Cureus. 2024. PMID: 38440035 Free PMC article.
Cryptogenic strokes attributable to PFO present an important clinical occurrence because they do not fit the typical template regarding those most at risk for such acutely devastating outcomes, making their identification uniquely important for both immediate and long-term …
Cryptogenic strokes attributable to PFO present an important clinical occurrence because they do not fit the typical template regarding thos …
Through a computer monitor darkly: artificial intelligence in absorption, distribution, metabolism and excretion science.
Smith DA, Burton LM, Amanda S. Smith DA, et al. Xenobiotica. 2023 Dec 14:1-15. doi: 10.1080/00498254.2023.2295361. Online ahead of print. Xenobiotica. 2023. PMID: 38095217 Review.
The literature contains many flaws, protein binding influence on unbound drug concentration, is one of the examples cited, and without direction AI may help to popularise them.ADME science has a relatively small number of key assays and values but these are produced under widely …
The literature contains many flaws, protein binding influence on unbound drug concentration, is one of the examples cited, and without direc …
Association of Long-term Exposure to Air Pollution and Dementia Risk: The Role of Homocysteine, Methionine, and Cardiovascular Burden.
Grande G, Hooshmand B, Vetrano DL, Smith DA, Refsum H, Fratiglioni L, Ljungman P, Wu J, Bellavia A, Eneroth K, Bellander T, Rizzuto D. Grande G, et al. Among authors: smith da. Neurology. 2023 Sep 19;101(12):e1231-e1240. doi: 10.1212/WNL.0000000000207656. Epub 2023 Jul 13. Neurology. 2023. PMID: 37442622 Free PMC article.
Semi-automated Segmentation and Quantification of Perivascular Spaces at 7 Tesla in COVID-19.
Langan MT, Smith DA, Verma G, Khegai O, Saju S, Rashid S, Ranti D, Markowitz M, Belani P, Jette N, Mathew B, Goldstein J, Kirsch CFE, Morris LS, Becker JH, Delman BN, Balchandani P. Langan MT, et al. Among authors: smith da. Front Neurol. 2022 Apr 1;13:846957. doi: 10.3389/fneur.2022.846957. eCollection 2022. Front Neurol. 2022. PMID: 35432151 Free PMC article.
Due to the novelty of COVID-19, there is a need to better understand the possible long-term effects it may have on patients, particularly linkage to neuroinflammatory processes. ...
Due to the novelty of COVID-19, there is a need to better understand the possible long-term effects it may have on patients, particul …
Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure.
Smith DA, Fernandez-Antunez C, Magri A, Bowden R, Chaturvedi N, Fellay J, McLauchlan J, Foster GR, Irving WL; STOP-HCV Consortium; Simmonds P, Pedergnana V, Ramirez S, Bukh J, Barnes E, Ansari MA. Smith DA, et al. Nat Commun. 2021 Oct 20;12(1):6105. doi: 10.1038/s41467-021-25649-6. Nat Commun. 2021. PMID: 34671027 Free PMC article.
They are also associated with lower reductions in viral load in the first week of therapy. Using in vitro short-term dose-response assays, these polymorphisms do not cause any reduction in sofosbuvir potency, suggesting an indirect mechanism of action in decreasing sofosbu …
They are also associated with lower reductions in viral load in the first week of therapy. Using in vitro short-term dose-response as …
A Foundational Guide to Understanding Radiology Department Business Operations for Trainees.
Parikh KD, Smith DA, Kasprzak TP, Stovicek B, Pandya H, Ramaiya NH. Parikh KD, et al. Among authors: smith da. J Am Coll Radiol. 2021 Jun;18(6):868-876. doi: 10.1016/j.jacr.2020.11.009. Epub 2020 Dec 14. J Am Coll Radiol. 2021. PMID: 33326756 Review.
Radiology leaders strategically balance these revenue streams with various departmental costs utilizing tools such as budgets and forecasts to ensure long-term organizational viability. Notably, payment practices in the United States are transforming from fee-for-service t …
Radiology leaders strategically balance these revenue streams with various departmental costs utilizing tools such as budgets and forecasts …
A phase 2 study of ofatumumab (Arzerra®) in combination with a pan-AKT inhibitor (afuresertib) in previously treated patients with chronic lymphocytic leukemia (CLL).
Chen CI, Paul H, Le LW, Wei EN, Snitzler S, Wang T, Levina O, Kakar S, Lau A, Queau M, Johnston JB, Smith DA, Trudel S. Chen CI, et al. Among authors: smith da. Leuk Lymphoma. 2019 Jan;60(1):92-100. doi: 10.1080/10428194.2018.1468892. Epub 2018 Jun 19. Leuk Lymphoma. 2019. PMID: 29916761 Clinical Trial.
We aimed to achieve deeper and more durable responses, without requiring long-term continuous treatment. Treatment was generally well tolerated but respiratory infections were common, with 18% severe requiring hospitalization. ...
We aimed to achieve deeper and more durable responses, without requiring long-term continuous treatment. Treatment was generally well …
Pancreatitis and Systemic Coronavirus Infection in a Ferret (Mustela putorius furo).
Wills SE, Beaufrère HH, Brisson BA, Fraser RS, Smith DA. Wills SE, et al. Among authors: smith da. Comp Med. 2018 Jun 1;68(3):208-211. doi: 10.30802/AALAS-CM-17-000109. Epub 2018 May 18. Comp Med. 2018. PMID: 29776456 Free PMC article.
Although FSCD has been reported extensively, this case is noteworthy for the presence of suppurative pancreatitis and the positive long-term outcome after corticosteroid therapy....
Although FSCD has been reported extensively, this case is noteworthy for the presence of suppurative pancreatitis and the positive long-t …
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA. O'Neill PM, et al. Among authors: smith da. Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159. Nat Commun. 2017. PMID: 28537265 Free PMC article.
K13 gene mutations are a primary marker of artemisinin resistance in Plasmodium falciparum malaria that threatens the long-term clinical utility of artemisinin-based combination therapies, the cornerstone of modern day malaria treatment. ...
K13 gene mutations are a primary marker of artemisinin resistance in Plasmodium falciparum malaria that threatens the long-term clini …
Diagnosis and Management of Polycythemia Vera in a Ferret (Mustela putorius furo).
Le K, Beaufrère H, Bassel LL, Wills S, Laniesse D, Blois SL, Smith DA. Le K, et al. Among authors: smith da. Comp Med. 2016 Dec 1;66(6):463-467. Comp Med. 2016. PMID: 28304249 Free PMC article.
To our knowledge, this report is the first to describe the diagnosis and long-term management of polycythemia vera in a ferret and the use of hydroxyurea for this purpose....
To our knowledge, this report is the first to describe the diagnosis and long-term management of polycythemia vera in a ferret and th …
51 results