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The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study.
Dicker AJ, Lonergan M, Keir HR, Smith AH, Pollock J, Finch S, Cassidy AJ, Huang JTJ, Chalmers JD. Dicker AJ, et al. Among authors: smith ah. Lancet Respir Med. 2021 Aug;9(8):885-896. doi: 10.1016/S2213-2600(20)30557-9. Epub 2021 May 4. Lancet Respir Med. 2021. PMID: 33961805
We aimed to evaluate the role of the microbiome in determining the risk of exacerbation and long-term outcomes, including all-cause mortality, in bronchiectasis. ...Microbiome characteristics were analysed for their association with measures of clinical disease severity an …
We aimed to evaluate the role of the microbiome in determining the risk of exacerbation and long-term outcomes, including all-cause m …
Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury.
Smith AH, Putta P, Driscoll EC, Chaudhuri P, Birnbaumer L, Rosenbaum MA, Graham LM. Smith AH, et al. JVS Vasc Sci. 2020;1:136-150. doi: 10.1016/j.jvssci.2020.07.002. Epub 2020 Jul 28. JVS Vasc Sci. 2020. PMID: 33554153 Free PMC article.
OBJECTIVE: Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endothelial healing of arterial injuries in hypercholesterolemic animals. Long-term studies utilizing a carotid wire-injury model were underta …
OBJECTIVE: Previous studies showed the benefit of canonical transient receptor potential 6 (TRPC6) channel deficiency in promoting endotheli …
Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study.
Rentsch CT, Edelman EJ, Justice AC, Marshall BDL, Xu K, Smith AH, Crystal S, Gaither JR, Gordon AJ, Smith RV, Kember RL, Polimanti R, Gelernter J, Fiellin DA, Tate JP, Kranzler HR, Becker WC; VACS Project Team. Rentsch CT, et al. Among authors: smith ah. AIDS Behav. 2019 Dec;23(12):3340-3349. doi: 10.1007/s10461-019-02608-3. AIDS Behav. 2019. PMID: 31317364 Free PMC article.
A better understanding of predisposition to transition to high-dose, long-term opioid therapy after initial opioid receipt could facilitate efforts to prevent opioid use disorder (OUD). ...
A better understanding of predisposition to transition to high-dose, long-term opioid therapy after initial opioid receipt could faci …
Extracorporeal membrane oxygenation use in the first 24 hours following pediatric heart transplantation: Incidence, risk factors, and outcomes.
Godown J, Bearl DW, Thurm C, Hall M, Feingold B, Soslow JH, Mettler BA, Smith AH, Profita EL, Singh TP, Dodd DA. Godown J, et al. Among authors: smith ah. Pediatr Transplant. 2019 Jun;23(4):e13414. doi: 10.1111/petr.13414. Epub 2019 Apr 11. Pediatr Transplant. 2019. PMID: 30973190 Free PMC article.
Survival to discharge decreased with increasing duration of post-HTx ECMO support; 89% for 1-3 days, 79.1% for 4-6 days, 63.2% for 7-9 days, and 18.8% for 10 days. There was no difference in long-term survival for patients requiring post-HTx ECMO who survived to hospital d …
Survival to discharge decreased with increasing duration of post-HTx ECMO support; 89% for 1-3 days, 79.1% for 4-6 days, 63.2% for 7-9 days, …
Center Variation in Hospital Costs for Pediatric Heart Transplantation: The Relationship Between Cost and Outcomes.
Godown J, Thurm C, Hall M, Dodd DA, Feingold B, Soslow JH, Mettler BA, Smith AH, Bearl DW, Schumacher KR. Godown J, et al. Among authors: smith ah. Pediatr Cardiol. 2019 Feb;40(2):357-365. doi: 10.1007/s00246-018-2011-8. Epub 2018 Oct 20. Pediatr Cardiol. 2019. PMID: 30343331 Free PMC article.
Patients transplanted at high-cost centers have a higher predicted risk of in-hospital mortality (8.1% vs. 6.1%, p < 0.001). Both early (p = 0.008) and long-term (p = 0.003) post-transplant survival were better in patients transplanted at low-cost centers. ...

Patients transplanted at high-cost centers have a higher predicted risk of in-hospital mortality (8.1% vs. 6.1%, p < 0.001). Both early (

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Age at Exposure to Arsenic in Water and Mortality 30-40 Years After Exposure Cessation.
Roh T, Steinmaus C, Marshall G, Ferreccio C, Liaw J, Smith AH. Roh T, et al. Among authors: smith ah. Am J Epidemiol. 2018 Nov 1;187(11):2297-2305. doi: 10.1093/aje/kwy159. Am J Epidemiol. 2018. PMID: 30084889 Free PMC article.
Increased SMRs for lung, bladder, and laryngeal cancer were evident for exposures starting at all ages, but the highest SMRs were for exposures beginning at birth (for bladder cancer, SMR = 16.0 (95% CI: 10.3, 23.8); for laryngeal cancer, SMR = 6.8 (95% CI: 2.2, 15.8); for …
Increased SMRs for lung, bladder, and laryngeal cancer were evident for exposures starting at all ages, but the highest SMRs were for exposu …
High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile.
Steinmaus C, Ferreccio C, Acevedo J, Balmes JR, Liaw J, Troncoso P, Dauphiné DC, Nardone A, Smith AH. Steinmaus C, et al. Among authors: smith ah. Toxicol Appl Pharmacol. 2016 Dec 15;313:10-15. doi: 10.1016/j.taap.2016.10.006. Epub 2016 Oct 8. Toxicol Appl Pharmacol. 2016. PMID: 27725189 Free PMC article.
BACKGROUND: Arsenic in drinking water has been associated with increases in lung disease, but information on the long-term impacts of early-life exposure or moderate exposure levels are limited. METHODS: We investigated pulmonary disease and lung function in 795 subjects f …
BACKGROUND: Arsenic in drinking water has been associated with increases in lung disease, but information on the long-term impacts of …
SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Glerup S, Bolcho U, Mølgaard S, Bøggild S, Vaegter CB, Smith AH, Nieto-Gonzalez JL, Ovesen PL, Pedersen LF, Fjorback AN, Kjolby M, Login H, Holm MM, Andersen OM, Nyengaard JR, Willnow TE, Jensen K, Nykjaer A. Glerup S, et al. Among authors: smith ah. Mol Psychiatry. 2016 Dec;21(12):1740-1751. doi: 10.1038/mp.2016.108. Epub 2016 Jul 26. Mol Psychiatry. 2016. PMID: 27457814
This defect was traced to the ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-derived neurotrophic factor (BDNF) to induce long-term depression, and with the BDNF receptor tyrosine kinase TrkB to elicit long-term p …
This defect was traced to the ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-derived ne …
Elevated lung cancer in younger adults and low concentrations of arsenic in water.
Steinmaus C, Ferreccio C, Yuan Y, Acevedo J, González F, Perez L, Cortés S, Balmes JR, Liaw J, Smith AH. Steinmaus C, et al. Among authors: smith ah. Am J Epidemiol. 2014 Dec 1;180(11):1082-7. doi: 10.1093/aje/kwu238. Epub 2014 Nov 4. Am J Epidemiol. 2014. PMID: 25371173 Free PMC article.
The unusual geology and good information on past exposure found in northern Chile are key advantages for investigating the potential long-term effects of arsenic. We performed a case-control study of lung cancer from 2007 to 2010 in areas of northern Chile that had a wide …
The unusual geology and good information on past exposure found in northern Chile are key advantages for investigating the potential long- …
Increased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure.
Steinmaus C, Ferreccio C, Acevedo J, Yuan Y, Liaw J, Durán V, Cuevas S, García J, Meza R, Valdés R, Valdés G, Benítez H, VanderLinde V, Villagra V, Cantor KP, Moore LE, Perez SG, Steinmaus S, Smith AH. Steinmaus C, et al. Among authors: smith ah. Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1529-38. doi: 10.1158/1055-9965.EPI-14-0059. Epub 2014 May 23. Cancer Epidemiol Biomarkers Prev. 2014. PMID: 24859871 Free PMC article.
IMPACT: Policies aimed at reducing early-life exposure may help reduce the long-term risks of arsenic-related disease....
IMPACT: Policies aimed at reducing early-life exposure may help reduce the long-term risks of arsenic-related disease....
32 results