Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

21 results

Filters applied: . Clear all
Page 1
PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults.
Bogaards FA, Gehrmann T, Beekman M, van den Akker EB, van de Rest O, Hangelbroek RWJ, Noordam R, Mooijaart SP, de Groot LCPGM, Reinders MJT, Slagboom PE. Bogaards FA, et al. Among authors: slagboom pe. FASEB J. 2022 Nov;36(11):e22578. doi: 10.1096/fj.202201037R. FASEB J. 2022. PMID: 36183353
To conclude, we found that the sex-specific PLIS score was able to track the individual short-term metabolic health gain of the GOTO lifestyle intervention study. ...
To conclude, we found that the sex-specific PLIS score was able to track the individual short-term metabolic health gain of the GOTO …
The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging.
Wiersema JM, Kamphuis AEP, Rohling JHT, Kervezee L, Akintola AA, Jansen SW, Slagboom PE, van Heemst D, van der Spoel E. Wiersema JM, et al. Among authors: slagboom pe. Aging (Albany NY). 2022 Aug 16;14(18):7223-7239. doi: 10.18632/aging.204219. Epub 2022 Aug 16. Aging (Albany NY). 2022. PMID: 35980264 Free PMC article.
Interestingly, middle-aged participants had a less optimal HRV during long-term recordings in both the sleep and awake periods, which might indicate that their heart is less adaptable than that of young participants. ...
Interestingly, middle-aged participants had a less optimal HRV during long-term recordings in both the sleep and awake periods, which …
Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort.
Stokes CS, Weber D, Wagenpfeil S, Stuetz W, Moreno-Villanueva M, Dollé MET, Jansen E, Gonos ES, Bernhardt J, Grubeck-Loebenstein B, Fiegl S, Sikora E, Toussaint O, Debacq-Chainiaux F, Capri M, Hervonen A, Slagboom PE, Breusing N, Frank J, Bürkle A, Franceschi C, Grune T. Stokes CS, et al. Among authors: slagboom pe. Br J Nutr. 2022 Aug 14;128(3):433-443. doi: 10.1017/S0007114521004633. Epub 2021 Nov 19. Br J Nutr. 2022. PMID: 34794520 Free PMC article.
Lower vitamin A and D status emerged as independent markers for fair/poor SRH. Further insights into the long-term implications of these modifiable nutrients on health status are warranted....
Lower vitamin A and D status emerged as independent markers for fair/poor SRH. Further insights into the long-term implications of th …
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood.
Maas SCE, Vidaki A, Teumer A, Costeira R, Wilson R, van Dongen J, Beekman M, Völker U, Grabe HJ, Kunze S, Ladwig KH, van Meurs JBJ, Uitterlinden AG, Voortman T, Boomsma DI, Slagboom PE, van Heemst D, van der Kallen CJH, van den Berg LH, Waldenberger M, Völzke H, Peters A, Bell JT, Ikram MA, Ghanbari M, Kayser M. Maas SCE, et al. Among authors: slagboom pe. Clin Epigenetics. 2021 Oct 26;13(1):198. doi: 10.1186/s13148-021-01186-3. Clin Epigenetics. 2021. PMID: 34702360 Free PMC article.
BACKGROUND: Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas. ...
BACKGROUND: Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and oth …
Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population.
Julkunen H, Cichońska A, Slagboom PE, Würtz P; Nightingale Health UK Biobank Initiative. Julkunen H, et al. Among authors: slagboom pe. Elife. 2021 May 4;10:e63033. doi: 10.7554/eLife.63033. Elife. 2021. PMID: 33942721 Free PMC article.
However, the risk for severe pneumonia occurring during the first 2 years after blood sampling for people with elevated levels of the multi-biomarker score was over four times higher than for long-term risk (8.0 [4.1-15.6]). If these hypothesis generating findings on incre …
However, the risk for severe pneumonia occurring during the first 2 years after blood sampling for people with elevated levels of the multi- …
Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data.
Pool R, Hagenbeek FA, Hendriks AM, van Dongen J, Willemsen G, de Geus E; BBMRI Metabolomics Consortium; Willems van Dijk K, Verhoeven A, Suchiman HE, Beekman M, Slagboom PE, Harms AC, Hankemeier T, Boomsma DI. Pool R, et al. Among authors: slagboom pe. Twin Res Hum Genet. 2020 Jun;23(3):145-155. doi: 10.1017/thg.2020.53. Twin Res Hum Genet. 2020. PMID: 32635965
Metabolites are small molecules involved in cellular metabolism where they act as reaction substrates or products. The term 'metabolomics' refers to the comprehensive study of these molecules. ...
Metabolites are small molecules involved in cellular metabolism where they act as reaction substrates or products. The term 'metabolo …
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals.
Deelen J, Kettunen J, Fischer K, van der Spek A, Trompet S, Kastenmüller G, Boyd A, Zierer J, van den Akker EB, Ala-Korpela M, Amin N, Demirkan A, Ghanbari M, van Heemst D, Ikram MA, van Klinken JB, Mooijaart SP, Peters A, Salomaa V, Sattar N, Spector TD, Tiemeier H, Verhoeven A, Waldenberger M, Würtz P, Davey Smith G, Metspalu A, Perola M, Menni C, Geleijnse JM, Drenos F, Beekman M, Jukema JW, van Duijn CM, Slagboom PE. Deelen J, et al. Among authors: slagboom pe. Nat Commun. 2019 Aug 20;10(1):3346. doi: 10.1038/s41467-019-11311-9. Nat Commun. 2019. PMID: 31431621 Free PMC article.
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic predictors of long-term mortality in the circulation of 44,168 individuals (age a …
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-stand …
Do senescence markers correlate in vitro and in situ within individual human donors?
Waaijer MEC, Gunn DA, van Heemst D, Slagboom PE, Sedivy JM, Dirks RW, Tanke HJ, Westendorp RGJ, Maier AB. Waaijer MEC, et al. Among authors: slagboom pe. Aging (Albany NY). 2018 Feb 28;10(2):278-289. doi: 10.18632/aging.101389. Aging (Albany NY). 2018. PMID: 29500330 Free PMC article.
Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal fibroblasts were assessed for reactive oxygen species (ROS), telomere-associated foci (TAF), p16INK4a and senescence-associated beta-gal (S …
Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal …
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.
Tobi EW, Slieker RC, Luijk R, Dekkers KF, Stein AD, Xu KM; Biobank-based Integrative Omics Studies Consortium; Slagboom PE, van Zwet EW, Lumey LH, Heijmans BT. Tobi EW, et al. Among authors: slagboom pe. Sci Adv. 2018 Jan 31;4(1):eaao4364. doi: 10.1126/sciadv.aao4364. eCollection 2018 Jan. Sci Adv. 2018. PMID: 29399631 Free PMC article.
Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in early life on long-term metabolic health. The specific mechanism awaits elucidation....
Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in e …
21 results