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Long-Term Outcomes of Resynchronization-Defibrillation for Heart Failure.
Sapp JL, Sivakumaran S, Redpath CJ, Khan H, Parkash R, Exner DV, Healey JS, Thibault B, Sterns LD, Lam NHN, Manlucu J, Mokhtar A, Sumner G, McKinlay S, Kimber S, Mondesert B, Talajic M, Rouleau J, McCarron CE, Wells G, Tang ASL; RAFT Long-Term Study Team. Sapp JL, et al. Among authors: sivakumaran s. N Engl J Med. 2024 Jan 18;390(3):212-220. doi: 10.1056/NEJMoa2304542. N Engl J Med. 2024. PMID: 38231622 Clinical Trial.
We assessed long-term outcomes among patients at the eight highest-enrolling participating sites. ...RESULTS: The trial enrolled 1798 patients, of whom 1050 were included in the long-term survival trial; the median duration of follow-up for the 1050 patients was 7.7 …
We assessed long-term outcomes among patients at the eight highest-enrolling participating sites. ...RESULTS: The trial enrolled 1798 …
PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
Caiati MD, Safiulina VF, Fattorini G, Sivakumaran S, Legname G, Cherubini E. Caiati MD, et al. Among authors: sivakumaran s. J Neurosci. 2013 Feb 13;33(7):2973-83. doi: 10.1523/JNEUROSCI.4149-12.2013. J Neurosci. 2013. PMID: 23407955 Free PMC article.
To this aim, calcium transients associated with giant depolarizing potentials, a hallmark of developmental networks, were transiently paired with mossy fiber activation in such a way that the two events were coincident. While this procedure caused long-term potentiation (L …
To this aim, calcium transients associated with giant depolarizing potentials, a hallmark of developmental networks, were transiently paired …
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Caiati MD, Sivakumaran S, Lanore F, Mulle C, Richard E, Verrier D, Marsicano G, Miles R, Cherubini E. Caiati MD, et al. Among authors: sivakumaran s. Sci Rep. 2012;2:285. doi: 10.1038/srep00285. Epub 2012 Feb 24. Sci Rep. 2012. PMID: 22368777 Free PMC article.
Early in postnatal life, mossy fibres (MF), the axons of granule cells in the dentate gyrus, release GABA which is depolarizing and excitatory. Synaptic currents undergo spike-time dependent long-term depression (STD-LTD) regardless of the temporal order of stimulation (pr …
Early in postnatal life, mossy fibres (MF), the axons of granule cells in the dentate gyrus, release GABA which is depolarizing and excitato …
In the developing hippocampus kainate receptors control the release of GABA from mossy fiber terminals via a metabotropic type of action.
Cherubini E, Caiati MD, Sivakumaran S. Cherubini E, et al. Among authors: sivakumaran s. Adv Exp Med Biol. 2011;717:11-26. doi: 10.1007/978-1-4419-9557-5_2. Adv Exp Med Biol. 2011. PMID: 21713663 Review.
At immature MF-CA3 synapses pairing MF stimulation with postsynaptic spiking and vice versa induces long term depression of MF-evoked GABAergic currents. In the case of positive pairing synaptic depression can be switched into spike-time dependent potentiation by blocking …
At immature MF-CA3 synapses pairing MF stimulation with postsynaptic spiking and vice versa induces long term depression of MF-evoked …
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
Flutter B, Edwards N, Fallah-Arani F, Henderson S, Chai JG, Sivakumaran S, Ghorashian S, Bennett CL, Freeman GJ, Sykes M, Chakraverty R. Flutter B, et al. Among authors: sivakumaran s. J Clin Invest. 2010 Nov;120(11):3855-68. doi: 10.1172/JCI41446. Epub 2010 Oct 18. J Clin Invest. 2010. PMID: 20978352 Free PMC article.
These 2 factors acted together to induce even more profound failure in long-term immunosurveillance. Crucially, the functions of exhausted CD8+ T cells could be partially restored by late in vivo blockade of the interaction between PD-1 and its ligand, PD-L1, without induc …
These 2 factors acted together to induce even more profound failure in long-term immunosurveillance. Crucially, the functions of exha …
Control of GABA Release at Mossy Fiber-CA3 Connections in the Developing Hippocampus.
Safiulina VF, Caiati MD, Sivakumaran S, Bisson G, Migliore M, Cherubini E. Safiulina VF, et al. Among authors: sivakumaran s. Front Synaptic Neurosci. 2010 Feb 22;2:1. doi: 10.3389/neuro.19.001.2010. eCollection 2010. Front Synaptic Neurosci. 2010. PMID: 21423487 Free PMC article.
We found that GABA(A)-mediated postsynaptic currents (MF-GPSCs) exhibited a very low probability of release, were sensitive to L-AP4, a group III metabotropic glutamate receptor agonist, and revealed short-term frequency-dependent facilitation. Moreover, MF-GPSCs were down …
We found that GABA(A)-mediated postsynaptic currents (MF-GPSCs) exhibited a very low probability of release, were sensitive to L-AP4, a grou …
At immature mossy-fiber-CA3 synapses, correlated presynaptic and postsynaptic activity persistently enhances GABA release and network excitability via BDNF and cAMP-dependent PKA.
Sivakumaran S, Mohajerani MH, Cherubini E. Sivakumaran S, et al. J Neurosci. 2009 Feb 25;29(8):2637-47. doi: 10.1523/JNEUROSCI.5019-08.2009. J Neurosci. 2009. PMID: 19244539 Free PMC article.
Depending on the relative timing, pairing postsynaptic spiking and single MF-GPSPs induced bidirectional changes in synaptic efficacy. In case of positive pairing, spike-timing-dependent-long-term potentiation (STD-LTP) was associated with a persistent increase in GPSP slo …
Depending on the relative timing, pairing postsynaptic spiking and single MF-GPSPs induced bidirectional changes in synaptic efficacy. In ca …
Outcome of the Fidelis implantable cardioverter-defibrillator lead advisory: a report from the Canadian Heart Rhythm Society Device Advisory Committee.
Krahn AD, Champagne J, Healey JS, Cameron D, Simpson CS, Thibault B, Mangat I, Tung S, Sterns L, Birnie DH, Exner DV, Parkash R, Sivakumaran S, Davies T, Coutu B, Crystal E, Wolfe K, Verma A, Stephenson EA, Sanatani S, Gow R, Connors S, Paredes FA, Essebag V; Canadian Heart Rhythm Society Device Advisory Committee. Krahn AD, et al. Among authors: sivakumaran s. Heart Rhythm. 2008 May;5(5):639-42. doi: 10.1016/j.hrthm.2008.01.029. Epub 2008 Jan 29. Heart Rhythm. 2008. PMID: 18452862
OBJECTIVE: The purpose of this study was to contact pediatric and adult implantable cardioverter-defibrillator (ICD) implant centers across Canada to determine the short-term response to the October 15, 2007 Medtronic Fidelis lead advisory. ...
OBJECTIVE: The purpose of this study was to contact pediatric and adult implantable cardioverter-defibrillator (ICD) implant centers across …
The impact of CCA-treated posts in vineyards on soil and ground water.
Greven M, Green S, Robinson B, Clothier B, Vogeler I, Agnew R, Neal S, Sivakumaran S. Greven M, et al. Among authors: sivakumaran s. Water Sci Technol. 2007;56(2):161-8. doi: 10.2166/wst.2007.485. Water Sci Technol. 2007. PMID: 17849991
Further modelling revealed a steady plume of As moving downwards after about 200-300 years. However, long-term hydrogeological modelling showed that sufficient aquifer water flow prevented the accumulation of CCA in the ground water. ...
Further modelling revealed a steady plume of As moving downwards after about 200-300 years. However, long-term hydrogeological modell …
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