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Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial.
Williams Roberson S, Nwosu S, Collar EM, Kiehl AL, Harrison FE, Bastarache J, Wilson JE, Mart MF, Sevransky JE, Ely EW, Lindsell CJ, Jackson JC; VICTAS Investigators. Williams Roberson S, et al. JAMA Netw Open. 2023 Feb 1;6(2):e230380. doi: 10.1001/jamanetworkopen.2023.0380. JAMA Netw Open. 2023. PMID: 36853612 Free PMC article. Clinical Trial.
IMPORTANCE: Sepsis is associated with long-term cognitive impairment and worse psychological and functional outcomes. ...These findings challenge the hypothesis that antioxidant and anti-inflammatory therapy during critical illness mitigates the development of long-term
IMPORTANCE: Sepsis is associated with long-term cognitive impairment and worse psychological and functional outcomes. ...These findin …
AAV gene therapy in companion dogs with severe hemophilia: Real-world long-term data on immunogenicity, efficacy, and quality of life.
Doshi BS, Samelson-Jones BJ, Nichols TC, Merricks EP, Siner JL, French RA, Lee BJ, Arruda VR, Callan MB. Doshi BS, et al. Among authors: siner jl. Mol Ther Methods Clin Dev. 2024 Feb 2;32(1):101205. doi: 10.1016/j.omtm.2024.101205. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2024. PMID: 38374963 Free PMC article.
The canine hemophilia model has proven to be one of the best predictors of therapeutic response in humans. Here, we report long-term follow-up of 12 companion dogs with severe hemophilia that were treated in a real-world setting with AAV gene therapy. ...
The canine hemophilia model has proven to be one of the best predictors of therapeutic response in humans. Here, we report long-term