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Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments.
Alaghband Y, Klein PM, Kramár EA, Cranston MN, Perry BC, Shelerud LM, Kane AE, Doan NL, Ru N, Acharya MM, Wood MA, Sinclair DA, Dickstein DL, Soltesz I, Limoli CL, Baulch JE. Alaghband Y, et al. Among authors: sinclair da. Cell Mol Life Sci. 2023 Jan 6;80(1):29. doi: 10.1007/s00018-022-04666-8. Cell Mol Life Sci. 2023. PMID: 36607431 Free PMC article.
Electrophysiology studies used to evaluate synaptic plasticity in the hippocampal CA1 region revealed significant reductions in long-term potentiation after each irradiation paradigm in both sexes. ...
Electrophysiology studies used to evaluate synaptic plasticity in the hippocampal CA1 region revealed significant reductions in long-term …
Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers.
Uddin GM, Youngson NA, Chowdhury SS, Hagan C, Sinclair DA, Morris MJ. Uddin GM, et al. Among authors: sinclair da. Cells. 2020 Mar 25;9(4):791. doi: 10.3390/cells9040791. Cells. 2020. PMID: 32218167 Free PMC article.
Glucose tolerance was tested at 10, 29 and 32 weeks of age to measure short and long term effects of post-weaning HFD, and NMN treatment. Plasma insulin and triglycerides, liver triglycerides and expression of mitochondrial metabolism-related genes were measured at 34 week …
Glucose tolerance was tested at 10, 29 and 32 weeks of age to measure short and long term effects of post-weaning HFD, and NMN treatm …
Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.
Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ. Uddin GM, et al. Among authors: sinclair da. Sci Rep. 2017 Nov 8;7(1):15063. doi: 10.1038/s41598-017-14866-z. Sci Rep. 2017. PMID: 29118320 Free PMC article.
Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upregulating mitochondrial biogenesis or function, via increased levels of nicotinamide adenine dinucleotide (NAD(+)). ...
Maternal overnutrition increases the risk of long-term metabolic dysfunction in offspring. Exercise improves metabolism partly by upr …
Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance.
Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC. Mohamad M, et al. Among authors: sinclair da. Aging Cell. 2016 Aug;15(4):706-15. doi: 10.1111/acel.12481. Epub 2016 Apr 20. Aging Cell. 2016. PMID: 27095270 Free PMC article.
To further define the role of fenestrations in hepatic insulin signaling without any of the long-term adaptive responses that occur with aging, we induced acute defenestration using poloxamer 407 (P407), and this replicated many of the age-related changes in hepatic glucos …
To further define the role of fenestrations in hepatic insulin signaling without any of the long-term adaptive responses that occur w …
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: sinclair da. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle …
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensiti …
Metformin improves healthspan and lifespan in mice.
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Martin-Montalvo A, et al. Among authors: sinclair da. Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192. Nat Commun. 2013. PMID: 23900241 Free PMC article.
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. ...
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin …
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Among authors: sinclair da. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1alpha-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibili …
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC- …
SIRT1 is essential for normal cognitive function and synaptic plasticity.
Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. Michán S, et al. Among authors: sinclair da. J Neurosci. 2010 Jul 21;30(29):9695-707. doi: 10.1523/JNEUROSCI.0027-10.2010. J Neurosci. 2010. PMID: 20660252 Free PMC article.
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Cohen HY, et al. Among authors: sinclair da. Science. 2004 Jul 16;305(5682):390-2. doi: 10.1126/science.1099196. Epub 2004 Jun 17. Science. 2004. PMID: 15205477
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....
11 results