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A cost-consequence model of using the 21-gene assay to identify patients with early-stage node-positive breast cancer who benefit from adjuvant chemotherapy in the Netherlands.
Simons MJHG, Machielsen PM, Spoorendonk JA, Ignacio T, Drost PB, Jacobs T, de Jongh FE. Simons MJHG, et al. J Med Econ. 2024 Jan-Dec;27(1):445-454. doi: 10.1080/13696998.2024.2324612. Epub 2024 Mar 12. J Med Econ. 2024. PMID: 38436289 Free article.
Many patients have no benefit from ACT and receive unnecessary, costly treatment often associated with short- and long-term adverse events (AEs). Gene expression profiling (GEP) assays, such as the 21-gene assay (i.e. the Oncotype DX assay), can identify patients at higher …
Many patients have no benefit from ACT and receive unnecessary, costly treatment often associated with short- and long-term adverse e …
Long-Term Outcomes of Eladocagene Exuparvovec Compared with Standard of Care in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Modelling Study.
Simons CL, Hwu WL, Zhang R, Simons MJHG, Bergkvist M, Bennison C. Simons CL, et al. Among authors: simons mjhg. Adv Ther. 2023 Dec;40(12):5399-5414. doi: 10.1007/s12325-023-02689-6. Epub 2023 Oct 6. Adv Ther. 2023. PMID: 37803205 Free PMC article.
INTRODUCTION: Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare disease with symptoms including movement disorders, developmental delays, and autonomic symptoms starting from birth; further, patients with AADC deficiency are at a high risk of death in the fir …
INTRODUCTION: Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare disease with symptoms including movement disorders, developmen …
Early-life telomere length predicts life-history strategy and reproductive senescence in a threatened wild songbird.
Morland F, Ewen JG, Simons MJP, Brekke P, Hemmings N. Morland F, et al. Among authors: simons mjp. Mol Ecol. 2023 Jul;32(14):4031-4043. doi: 10.1111/mec.16981. Epub 2023 May 12. Mol Ecol. 2023. PMID: 37173827 Free PMC article.
Whether these effects are caused by a change in lifespan, reproductive rate or perhaps most importantly reproductive senescence is unclear. Using long-term data on female breeding success from a threatened songbird (the hihi, Notiomystis cincta), we show that the early-lif …
Whether these effects are caused by a change in lifespan, reproductive rate or perhaps most importantly reproductive senescence is unclear. …
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis.
Phillips EJ, Simons MJP. Phillips EJ, et al. Among authors: simons mjp. Geroscience. 2023 Apr;45(2):1263-1270. doi: 10.1007/s11357-022-00691-4. Epub 2022 Nov 18. Geroscience. 2023. PMID: 36399256 Free PMC article.
Therefore, arguably, the most holistic measurement of immune function is survival from an acute pathogenic infection. We reanalysed published post-infection short-term survival data of mice (n = 1223 from 23 studies comprising 46 effect sizes involving DR (n = 17) and rapa …
Therefore, arguably, the most holistic measurement of immune function is survival from an acute pathogenic infection. We reanalysed publishe …
Early-life environment and differences in costs of reproduction in a preindustrial human population.
Nenko I, Hayward AD, Simons MJP, Lummaa V. Nenko I, et al. Among authors: simons mjp. PLoS One. 2018 Dec 12;13(12):e0207236. doi: 10.1371/journal.pone.0207236. eCollection 2018. PLoS One. 2018. PMID: 30540747 Free PMC article.
Reproduction is predicted to trade-off with long-term maternal survival, but the survival costs often vary between individuals, cohorts and populations, limiting our understanding of this trade-off, which is central to life-history theory. ...We quantified the effect of ea …
Reproduction is predicted to trade-off with long-term maternal survival, but the survival costs often vary between individuals, cohor …
HLA and nasopharyngeal carcinoma in Chinese--a further study.
Chan SH, Day NE, Kunaratnam N, Chia KB, Simons MJ. Chan SH, et al. Among authors: simons mj. Int J Cancer. 1983 Aug 15;32(2):171-6. doi: 10.1002/ijc.2910320206. Int J Cancer. 1983. PMID: 6874140
Earlier results had indicated an association with A2 and BW46, but the heterogeneity of the earlier case series, which contained a proportion of long-term survivors, obscured other aspects of the relationship. In this paper, the risk associated with A2 (relative risk = 1.5 …
Earlier results had indicated an association with A2 and BW46, but the heterogeneity of the earlier case series, which contained a proportio …
Nasopharyngeal carcinoma and histocompatibility antigens.
Simons MJ, Chan SH, Wee GB, Shanmugaratnam K, Goh EH, Ho JH, Chau JC, Darmalingam S, Prasad U, Betuel H, Day NE, de-The G. Simons MJ, et al. IARC Sci Publ (1971). 1978;(20):271-82. IARC Sci Publ (1971). 1978. PMID: 730194
When attention is confined to newly diagnosed cases, it can be shown that, apart from the increased risk associated with the joint occurrence of A2 and B-Sin 2, there is also an increased risk associated with BW17 and a decrease in risk associated with A11. Among long-term …
When attention is confined to newly diagnosed cases, it can be shown that, apart from the increased risk associated with the joint occurrenc …