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Human Health during Space Travel: State-of-the-Art Review.
Krittanawong C, Singh NK, Scheuring RA, Urquieta E, Bershad EM, Macaulay TR, Kaplin S, Dunn C, Kry SF, Russomano T, Shepanek M, Stowe RP, Kirkpatrick AW, Broderick TJ, Sibonga JD, Lee AG, Crucian BE. Krittanawong C, et al. Among authors: sibonga jd. Cells. 2022 Dec 22;12(1):40. doi: 10.3390/cells12010040. Cells. 2022. PMID: 36611835 Free PMC article. Review.
However, current evidence regarding human health in space is very limited, particularly pertaining to short-term and long-term space travel. This review synthesizes developments across the continuum of space health including prior studies and unpublished data from N …
However, current evidence regarding human health in space is very limited, particularly pertaining to short-term and long-term …
Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight.
Gabel L, Liphardt AM, Hulme PA, Heer M, Zwart SR, Sibonga JD, Smith SM, Boyd SK. Gabel L, et al. Among authors: sibonga jd. Sci Rep. 2022 Jun 30;12(1):9446. doi: 10.1038/s41598-022-13461-1. Sci Rep. 2022. PMID: 35773442 Free PMC article.
Determining the extent of bone recovery after prolonged spaceflight is important for understanding risks to astronaut long-term skeletal health. We examined bone strength, density, and microarchitecture in seventeen astronauts (14 males; mean 47 years) using high-resolutio …
Determining the extent of bone recovery after prolonged spaceflight is important for understanding risks to astronaut long-term skele …
Relations Between Bone Quantity, Microarchitecture, and Collagen Cross-links on Mechanics Following In Vivo Irradiation in Mice.
Pendleton MM, Emerzian SR, Sadoughi S, Li A, Liu JW, Tang SY, O'Connell GD, Sibonga JD, Alwood JS, Keaveny TM. Pendleton MM, et al. Among authors: sibonga jd. JBMR Plus. 2021 Sep 26;5(11):e10545. doi: 10.1002/jbm4.10545. eCollection 2021 Nov. JBMR Plus. 2021. PMID: 34761148 Free PMC article.
Mice were administered doses of either 0 Gy (sham), 1 Gy (motivated by cumulative exposures from a Mars mission), or 5 Gy (motivated by clinical therapy regimens) with retrieval of the lumbar vertebrae at either a short-term (11-day) or long-term (12-week) time poin …
Mice were administered doses of either 0 Gy (sham), 1 Gy (motivated by cumulative exposures from a Mars mission), or 5 Gy (motivated by clin …
Evaluating Bone Loss in ISS Astronauts.
Sibonga JD, Spector ER, Johnston SL, Tarver WJ. Sibonga JD, et al. Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A38-A44. doi: 10.3357/AMHP.EC06.2015. Aerosp Med Hum Perform. 2015. PMID: 26630194
Consequently, use of relatively new research technologies is being proposed to NASA for risk surveillance and to enhance long-term management of skeletal health in long-duration astronauts. Sibonga JD, Spector ER, Johnston SL, Tarver WJ. ...
Consequently, use of relatively new research technologies is being proposed to NASA for risk surveillance and to enhance long-term ma …
Bone metabolism and renal stone risk during International Space Station missions.
Smith SM, Heer M, Shackelford LC, Sibonga JD, Spatz J, Pietrzyk RA, Hudson EK, Zwart SR. Smith SM, et al. Among authors: sibonga jd. Bone. 2015 Dec;81:712-720. doi: 10.1016/j.bone.2015.10.002. Epub 2015 Oct 8. Bone. 2015. PMID: 26456109
Loss of bone calcium leads to concerns about fracture risk and increased long-term risk of osteoporosis. Bone metabolism involves many factors and is interconnected with muscle metabolism and diet. ...
Loss of bone calcium leads to concerns about fracture risk and increased long-term risk of osteoporosis. Bone metabolism involves man …
Long-term risedronate treatment normalizes mineralization and continues to preserve trabecular architecture: sequential triple biopsy studies with micro-computed tomography.
Borah B, Dufresne TE, Ritman EL, Jorgensen SM, Liu S, Chmielewski PA, Phipps RJ, Zhou X, Sibonga JD, Turner RT. Borah B, et al. Among authors: sibonga jd. Bone. 2006 Aug;39(2):345-52. doi: 10.1016/j.bone.2006.01.161. Epub 2006 Mar 29. Bone. 2006. PMID: 16571382 Clinical Trial.
The objective of the study was to assess the time course of changes in bone mineralization and architecture using sequential triple biopsies from women with postmenopausal osteoporosis (PMO) who received long-term treatment with risedronate. Transiliac biopsies were obtain …
The objective of the study was to assess the time course of changes in bone mineralization and architecture using sequential triple biopsies …
Moderate alcohol consumption suppresses bone turnover in adult female rats.
Turner RT, Kidder LS, Kennedy A, Evans GL, Sibonga JD. Turner RT, et al. Among authors: sibonga jd. J Bone Miner Res. 2001 Mar;16(3):589-94. doi: 10.1359/jbmr.2001.16.3.589. J Bone Miner Res. 2001. PMID: 11277278 Free article.
Chronic alcohol abuse is a major risk factor for osteoporosis but the effects of moderate drinking on bone metabolism are largely uninvestigated. Here, we studied the long-term dose-response (0, 3, 6, 13, and 35% caloric intake) effects of alcohol on cancellous bone in the …
Chronic alcohol abuse is a major risk factor for osteoporosis but the effects of moderate drinking on bone metabolism are largely uninvestig …
Lack of an effect of sodium zeolite A on rat tibia histomorphometry.
Firling CE, Evans GL, Wakley GK, Sibonga J, Turner RT. Firling CE, et al. Among authors: sibonga j. J Bone Miner Res. 1996 Feb;11(2):254-63. doi: 10.1002/jbmr.5650110215. J Bone Miner Res. 1996. PMID: 8822350 Free article.
Cell culture studies suggest that the aluminum silicate polymer sodium Zeolite A (SZA) increases bone cell proliferation and extracellular matrix production. This study in rats investigated the short-term (2 weeks) and long-term (18 weeks) in vivo effects of SZA on …
Cell culture studies suggest that the aluminum silicate polymer sodium Zeolite A (SZA) increases bone cell proliferation and extracellular m …
Ovarian status influences the skeletal effects of tamoxifen in adult rats.
Sibonga JD, Evans GL, Hauck ER, Bell NH, Turner RT. Sibonga JD, et al. Breast Cancer Res Treat. 1996;41(1):71-9. doi: 10.1007/BF01807038. Breast Cancer Res Treat. 1996. PMID: 8932878
In light of this clinical application in young women, the skeleton's potential predisposition for osteoporosis following long-term treatment with an antiestrogen is a concern. In postmenopausal women being treated for breast cancer TAM was shown to prevent bone loss. ...We …
In light of this clinical application in young women, the skeleton's potential predisposition for osteoporosis following long-term tr …