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Carotid Artery Bypass Surgery of In-Body Tissue Architecture-Induced Small-Diameter Biotube in a Goat Model: A Pilot Study.
Umeno T, Mori K, Iwai R, Kawashima T, Shuto T, Nakashima Y, Tajikawa T, Nakayama Y, Miyamoto S. Umeno T, et al. Among authors: shuto t. Bioengineering (Basel). 2024 Feb 21;11(3):203. doi: 10.3390/bioengineering11030203. Bioengineering (Basel). 2024. PMID: 38534477 Free PMC article.
We revealed the importance of Biotubes that are homogeneous, demonstrate a tensile strength > 5 N, and are implanted under appropriate antithrombotic conditions to achieve long-term patency of Biotube. Further, we clarified the Biotube regeneration process and the mecha …
We revealed the importance of Biotubes that are homogeneous, demonstrate a tensile strength > 5 N, and are implanted under appropriate an …
T3 Intratracheal Therapy Alleviates Pulmonary Pathology in an Elastase-Induced Emphysema-Dominant COPD Mouse Model.
Takahashi N, Nakashima R, Nasu A, Hayashi M, Fujikawa H, Kawakami T, Eto Y, Kishimoto T, Fukuyama A, Ogasawara C, Kawano K, Fujiwara Y, Suico MA, Kai H, Shuto T. Takahashi N, et al. Among authors: shuto t. Antioxidants (Basel). 2023 Dec 22;13(1):30. doi: 10.3390/antiox13010030. Antioxidants (Basel). 2023. PMID: 38247455 Free PMC article.
T(3)-dependent improvement is likely linked to the up-regulation of Ppargc1a, a master regulator of mitochondrial biogenesis, and Gclm, a factor associated with oxidative stress. Conversely, neither short- nor long-term T(3) treatments improved COPD pathology in the C57BL/ …
T(3)-dependent improvement is likely linked to the up-regulation of Ppargc1a, a master regulator of mitochondrial biogenesis, and Gclm, a fa …
Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial.
Saito Y, Tanaka A, Imai T, Nakamura I, Kanda J, Matsuhisa M, Uehara H, Kario K, Kobayashi Y, Node K; PROTECT investigators. Saito Y, et al. Hypertens Res. 2024 Jan;47(1):168-176. doi: 10.1038/s41440-023-01494-6. Epub 2023 Nov 14. Hypertens Res. 2024. PMID: 37964067 Clinical Trial.
Although previous reports have shown that sodium-glucose cotransporter-2 (SGLT2) inhibitors have a blood pressure (BP) lowering effect, relevant long-term data is limited. This study aimed to evaluate the effect of the SGLT2 inhibitor ipragliflozin on BP, and associations …
Although previous reports have shown that sodium-glucose cotransporter-2 (SGLT2) inhibitors have a blood pressure (BP) lowering effect, rele …
Outcomes of Gamma Knife Radiosurgery for Brain Metastases From Anaplastic Lymphoma Kinase Rearrangement-Positive and EGFR Mutation-Positive Non-Small Cell Lung Cancer.
Matsunaga S, Shuto T. Matsunaga S, et al. Among authors: shuto t. Cureus. 2021 Dec 13;13(12):e20398. doi: 10.7759/cureus.20398. eCollection 2021 Dec. Cureus. 2021. PMID: 35047245 Free PMC article.
Conclusions ALK rearrangement-positive NSCLC patients tended to have significantly longer survival, but had higher incidence of new intracranial metastases due to long-term survival after GKRS, compared with EGFR mutation-negative and driver gene mutation-negative NSCLC pa …
Conclusions ALK rearrangement-positive NSCLC patients tended to have significantly longer survival, but had higher incidence of new intracra …
Aortic valve neocuspidization with in-body tissue-engineered autologous membranes: preliminary results in a long-term goat model.
Kawashima T, Umeno T, Terazawa T, Wada T, Shuto T, Nishida H, Anai H, Nakayama Y, Miyamoto S. Kawashima T, et al. Among authors: shuto t. Interact Cardiovasc Thorac Surg. 2021 May 27;32(6):969-977. doi: 10.1093/icvts/ivab015. Interact Cardiovasc Thorac Surg. 2021. PMID: 33543242 Free PMC article.
This study applied an autologous collagenous membrane (Biosheet), produced by in-body tissue architecture, to aortic valve neocuspidization and investigated its long-term outcome in a goat model. METHODS: Moulds were embedded subcutaneously in 6 goats. ...
This study applied an autologous collagenous membrane (Biosheet), produced by in-body tissue architecture, to aortic valve neocuspidization …
The impact of EGFR-TKI use on clinical outcomes of lung adenocarcinoma patients with brain metastases after Gamma Knife radiosurgery: a propensity score-matched analysis based on extended JLGK0901 dataset (JLGK0901-EGFR-TKI).
Yomo S, Serizawa T, Yamamoto M, Higuchi Y, Sato Y, Shuto T, Akabane A, Jokura H, Kawagishi J, Aoyama H. Yomo S, et al. Among authors: shuto t. J Neurooncol. 2019 Oct;145(1):151-157. doi: 10.1007/s11060-019-03282-0. Epub 2019 Sep 5. J Neurooncol. 2019. PMID: 31487030

EGFR-TKI use was associated with longer OS (median 25.5 vs. 11.0 months, HR 0.60, 95% CI 0.48-0.75, p < 0.001), although the long-term OS curves eventually crossed. Distant intracranial recurrence was more likely in patients receiving EGFR-TKI (HR 1.45, 95% CI 1.12-1.89

EGFR-TKI use was associated with longer OS (median 25.5 vs. 11.0 months, HR 0.60, 95% CI 0.48-0.75, p < 0.001), although the long-term

Mild electrical stimulation with heat shock reduces inflammatory symptoms in the imiquimod-induced psoriasis mouse model.
Tsurekawa Y, Morita M, Suico MA, Moriuchi M, Nakano Y, Piruzyan M, Takada M, Fukami S, Shuto T, Kai H. Tsurekawa Y, et al. Among authors: shuto t. Exp Dermatol. 2018 Oct;27(10):1092-1097. doi: 10.1111/exd.13720. Epub 2018 Jul 30. Exp Dermatol. 2018. PMID: 29928760
Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biological responses by modulating intracellular signaling pathways. ...
Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces …
Ten-year experience of the thoraco-abdominal aortic aneurysm treatment using a hybrid thoracic endovascular aortic repair.
Shuto T, Wada T, Miyamoto S, Kamei N, Hongo N, Mori H. Shuto T, et al. Interact Cardiovasc Thorac Surg. 2018 Jun 1;26(6):951-956. doi: 10.1093/icvts/ivy021. Interact Cardiovasc Thorac Surg. 2018. PMID: 29415193
The other 2 patients died due to an aneurysmal rupture in the long-term period after preventive renovisceral debranching. Two (3%) patients experienced spinal cord ischaemia after the stenting procedure. ...CONCLUSIONS: The hybrid repair is considered to be a good option f …
The other 2 patients died due to an aneurysmal rupture in the long-term period after preventive renovisceral debranching. Two (3%) pa …
A Multi-institutional Prospective Observational Study of Stereotactic Radiosurgery for Patients With Multiple Brain Metastases (JLGK0901 Study Update): Irradiation-related Complications and Long-term Maintenance of Mini-Mental State Examination Scores.
Yamamoto M, Serizawa T, Higuchi Y, Sato Y, Kawagishi J, Yamanaka K, Shuto T, Akabane A, Jokura H, Yomo S, Nagano O, Aoyama H. Yamamoto M, et al. Among authors: shuto t. Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):31-40. doi: 10.1016/j.ijrobp.2017.04.037. Epub 2017 Aug 7. Int J Radiat Oncol Biol Phys. 2017. PMID: 28816158
However, observation periods were not long enough to allow confirmation of the long-term safety of SRS alone in patients with 5 to 10 BMs. METHODS AND MATERIALS: This was a prospective observational study of Gamma Knife SRS-treated patients with 1 to 10 newly diagnosed BMs …
However, observation periods were not long enough to allow confirmation of the long-term safety of SRS alone in patients with 5 to 10 …
32 results