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Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.
Xu Y, Hashizume T, Shuhart MC, Davis CL, Nelson WL, Sakaki T, Kalhorn TF, Watkins PB, Schuetz EG, Thummel KE. Xu Y, et al. Among authors: shuhart mc. Mol Pharmacol. 2006 Jan;69(1):56-65. doi: 10.1124/mol.105.017392. Epub 2005 Oct 5. Mol Pharmacol. 2006. PMID: 16207822
The decline in bone mineral density that occurs after long-term treatment with some antiepileptic drugs is thought to be mediated by increased vitamin D(3) metabolism. ...
The decline in bone mineral density that occurs after long-term treatment with some antiepileptic drugs is thought to be mediated by …
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia.
Wang Z, Lin YS, Dickmann LJ, Poulton EJ, Eaton DL, Lampe JW, Shen DD, Davis CL, Shuhart MC, Thummel KE. Wang Z, et al. Among authors: shuhart mc. J Bone Miner Res. 2013 May;28(5):1101-16. doi: 10.1002/jbmr.1839. J Bone Miner Res. 2013. PMID: 23212742 Free PMC article.
Long-term therapy with certain drugs, especially cytochrome P450 (P450; CYP)-inducing agents, confers an increased risk of osteomalacia that is attributed to vitamin D deficiency. ...With healthy volunteers, the mean plasma concentration of 4beta,25(OH)2D3 was increased 60 …
Long-term therapy with certain drugs, especially cytochrome P450 (P450; CYP)-inducing agents, confers an increased risk of osteomalac …
Marrow transplantation from hepatitis C virus seropositive donors: transmission rate and clinical course.
Shuhart MC, Myerson D, Childs BH, Fingeroth JD, Perry JJ, Snyder DS, Spurgeon CL, Bevan CA, McDonald GB. Shuhart MC, et al. Blood. 1994 Nov 1;84(9):3229-35. Blood. 1994. PMID: 7949194 Free article.
The acute infection was subclinical in all patients. The long-term risk of chronic hepatitis C virus infection in these patients remains to be determined....
The acute infection was subclinical in all patients. The long-term risk of chronic hepatitis C virus infection in these patients rema …
Hepatitis C virus (HCV) infection in bone marrow transplant patients after transfusions from anti-HCV-positive blood donors.
Shuhart MC, Myerson D, Spurgeon CL, Bevan CA, Sayers MH, McDonald GB. Shuhart MC, et al. Bone Marrow Transplant. 1996 Apr;17(4):601-6. Bone Marrow Transplant. 1996. PMID: 8722362
We conclude that HCV RNA-positivity in blood components accurately predicts transmission of virus. Infection with HCV did not adversely affect short-term patient outcome following bone marrow transplantation....
We conclude that HCV RNA-positivity in blood components accurately predicts transmission of virus. Infection with HCV did not adversely affe …