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Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy.
Mizuno K, Capparelli EV, Fukuda T, Dong M, Adamson PC, Blumer JL, Cnaan A, Clark PO, Reed MD, Shinnar S, Vinks AA, Glauser TA; Childhood Absence Epilepsy Study Group. Mizuno K, et al. Among authors: shinnar s. Clin Pharmacol Ther. 2023 Aug;114(2):459-469. doi: 10.1002/cpt.2965. Epub 2023 Jun 25. Clin Pharmacol Ther. 2023. PMID: 37316457 Clinical Trial.
However, 47% of ethosuximide initial monotherapy participants experienced short-term treatment failure. This study aimed to characterize the initial monotherapy ethosuximide exposure-response relationship and to propose model-informed precision dosing guidance. ...
However, 47% of ethosuximide initial monotherapy participants experienced short-term treatment failure. This study aimed to character …
Blood Pressure Classification Status in Children With CKD Following Adoption of the 2017 American Academy of Pediatrics Guideline.
Ng DK, Carroll MK, Furth SL, Warady BA, Flynn JT; CKiD Study Investigators. Ng DK, et al. Am J Kidney Dis. 2023 May;81(5):545-553. doi: 10.1053/j.ajkd.2022.10.009. Epub 2022 Dec 12. Am J Kidney Dis. 2023. PMID: 36521780
Overall, there was good reproducibility (kappa=0.799 [95% CI, 0.778-0.819]) of classification by ambulatory BP monitoring. LIMITATIONS: Relationship with long-term progression and target organ damage was not assessed. CONCLUSIONS: A greater percentage of children with CKD …
Overall, there was good reproducibility (kappa=0.799 [95% CI, 0.778-0.819]) of classification by ambulatory BP monitoring. LIMITATIONS: Rela …
Decreased Electroencephalographic Alpha Power During Anesthesia Induction Is Associated With EEG Discontinuity in Human Infants.
Chao JY, Gutiérrez R, Legatt AD, Yozawitz EG, Lo Y, Adams DC, Delphin ES, Shinnar S, Purdon PL. Chao JY, et al. Among authors: shinnar s. Anesth Analg. 2022 Dec 1;135(6):1207-1216. doi: 10.1213/ANE.0000000000005864. Epub 2022 Nov 16. Anesth Analg. 2022. PMID: 35041633 Free PMC article.
Isoelectric events on the EEG, a more extreme degree of voltage suppression, have been shown to be associated with worse long-term neurologic outcomes in neonates undergoing cardiac surgery. ...
Isoelectric events on the EEG, a more extreme degree of voltage suppression, have been shown to be associated with worse long-term ne …
Differences in brain changes between adults with childhood-onset epilepsy and controls: A prospective population-based study.
Sillanpää M, Hermann B, Rinne JO, Parkkola R, Saarinen MM, Karrasch M, Saunavaara J, Rissanen E, Joutsa J, Shinnar S. Sillanpää M, et al. Among authors: shinnar s. Acta Neurol Scand. 2022 Mar;145(3):322-331. doi: 10.1111/ane.13560. Epub 2021 Nov 26. Acta Neurol Scand. 2022. PMID: 34837220 Free PMC article.
In the combined study cohort of COE subjects and controls, presenting neurologic signs increased both in the subjects and in the controls from the 2012 to 2017 study. CONCLUSIONS: At ultra-long-term follow-up, clinical and neuroimaging findings show tendencies to brain agi …
In the combined study cohort of COE subjects and controls, presenting neurologic signs increased both in the subjects and in the controls fr …
Presurgical depression and anxiety are not associated with worse epilepsy surgery outcome five years postoperatively.
Altalib HH, Berg AT, Cong X, Vickrey BG, Sperling MR, Shinnar S, Langfitt JT, Walczak TS, Bazil CW, Sukumar N, Devinsky O. Altalib HH, et al. Among authors: shinnar s. Epilepsy Behav. 2018 Jun;83:7-12. doi: 10.1016/j.yebeh.2018.01.040. Epub 2018 Apr 7. Epilepsy Behav. 2018. PMID: 29631157
Depression was not a risk factor for poor epilepsy surgical outcome in the long term. CONCLUSION: These findings from a prospective study that utilized a standardized protocol for psychiatric and seizure outcome assessment suggest that presurgical mood disorders have no su …
Depression was not a risk factor for poor epilepsy surgical outcome in the long term. CONCLUSION: These findings from a prospective s …
Extrapolating evidence of antiepileptic drug efficacy in adults to children ≥2 years of age with focal seizures: The case for disease similarity.
Pellock JM, Arzimanoglou A, D'Cruz O, Holmes GL, Nordli D, Shinnar S; Pediatric Epilepsy Academic Consortium for Extrapolation. Pellock JM, et al. Among authors: shinnar s. Epilepsia. 2017 Oct;58(10):1686-1696. doi: 10.1111/epi.13859. Epub 2017 Jul 29. Epilepsia. 2017. PMID: 28755452 Review.
The scientific rationale, clinical consensus, and published data support a future approach accepting efficacy data from adult trials and focusing exclusively on prospective pharmacokinetic, tolerability, and safety studies and long-term follow-up in children. Whereas toler …
The scientific rationale, clinical consensus, and published data support a future approach accepting efficacy data from adult trials and foc …
Pretreatment seizure semiology in childhood absence epilepsy.
Kessler SK, Shinnar S, Cnaan A, Dlugos D, Conry J, Hirtz DG, Hu F, Liu C, Mizrahi EM, Moshé SL, Clark P, Glauser TA; Childhood Absence Epilepsy Study Group. Kessler SK, et al. Among authors: shinnar s. Neurology. 2017 Aug 15;89(7):673-679. doi: 10.1212/WNL.0000000000004226. Epub 2017 Jul 19. Neurology. 2017. PMID: 28724582 Free PMC article. Clinical Trial.
OBJECTIVE: To determine seizure semiology in children with newly diagnosed childhood absence epilepsy and to evaluate associations with short-term treatment outcomes. METHODS: For participants enrolled in a multicenter, randomized, double-blind, comparative-effectiveness t …
OBJECTIVE: To determine seizure semiology in children with newly diagnosed childhood absence epilepsy and to evaluate associations with shor …
Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis.
Lamberink HJ, Otte WM, Geerts AT, Pavlovic M, Ramos-Lizana J, Marson AG, Overweg J, Sauma L, Specchio LM, Tennison M, Cardoso TMO, Shinnar S, Schmidt D, Geleijns K, Braun KPJ. Lamberink HJ, et al. Among authors: shinnar s. Lancet Neurol. 2017 Jul;16(7):523-531. doi: 10.1016/S1474-4422(17)30114-X. Epub 2017 May 5. Lancet Neurol. 2017. PMID: 28483337 Free article. Review.
The objectives of our study were to identify predictors of seizure recurrence and long-term seizure outcomes and to produce nomograms for estimation of individualised outcomes. ...The nomograms facilitate prediction of outcomes following drug withdrawal for the individual …
The objectives of our study were to identify predictors of seizure recurrence and long-term seizure outcomes and to produce nomograms …
Remission in epilepsy: How long is enough?
Sillanpää M, Schmidt D, Saarinen MM, Shinnar S. Sillanpää M, et al. Among authors: shinnar s. Epilepsia. 2017 May;58(5):901-906. doi: 10.1111/epi.13732. Epub 2017 Apr 4. Epilepsia. 2017. PMID: 28374950 Free article.
Brain structure and organization five decades after childhood onset epilepsy.
Garcia-Ramos C, Bobholz S, Dabbs K, Hermann B, Joutsa J, Rinne JO, Karrasch M, Prabhakaran V, Shinnar S, Sillanpää M; TACOE Study Group. Garcia-Ramos C, et al. Among authors: shinnar s. Hum Brain Mapp. 2017 Jun;38(6):3289-3299. doi: 10.1002/hbm.23593. Epub 2017 Apr 3. Hum Brain Mapp. 2017. PMID: 28370719 Free PMC article.
Also, contrary to the group with remitted epilepsy, patients with active epilepsy presented most of their high BC Z-score regions in subcortical areas including the amygdala, thalamus, hippocampus, pallidum, and accumbens. Overall, this population-based investigation of long t …
Also, contrary to the group with remitted epilepsy, patients with active epilepsy presented most of their high BC Z-score regions in subcort …
59 results