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Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.
Rheault MN, Alpers CE, Barratt J, Bieler S, Canetta P, Chae DW, Coppock G, Diva U, Gesualdo L, Heerspink HJL, Inrig JK, Kirsztajn GM, Kohan D, Komers R, Kooienga LA, Lieberman K, Mercer A, Noronha IL, Perkovic V, Radhakrishnan J, Rote W, Rovin B, Tesar V, Trimarchi H, Tumlin J, Wong MG, Trachtman H; DUPRO Steering Committee and DUPLEX Investigators. Rheault MN, et al. N Engl J Med. 2023 Dec 28;389(26):2436-2445. doi: 10.1056/NEJMoa2308550. Epub 2023 Nov 3. N Engl J Med. 2023. PMID: 37921461 Clinical Trial.
In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The efficacy and safety of longer-term treatment with sparsentan for FSGS are unknown. METHODS: In this phase 3 trial, we enrolled patient …
In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The e …
Hypertensive patients using thiazide diuretics as primary stroke prevention make better functional outcome after ischemic stroke.
Shih HM, Lin WC, Wang CH, Lin LC. Shih HM, et al. J Stroke Cerebrovasc Dis. 2014 Oct;23(9):2414-8. doi: 10.1016/j.jstrokecerebrovasdis.2014.05.021. Epub 2014 Aug 31. J Stroke Cerebrovasc Dis. 2014. PMID: 25183562
CONCLUSION: Hypertensive patients treated with thiazides long term had a lesser severity of stroke and better functional outcomes after ischemic stroke....
CONCLUSION: Hypertensive patients treated with thiazides long term had a lesser severity of stroke and better functional outcomes aft …
Different sham procedures for rats in traumatic brain injury experiments induce corresponding increases in levels of trauma markers.
Wu JC, Chen KY, Yo YW, Huang SW, Shih HM, Chiu WT, Chiang YH, Shiau CY. Wu JC, et al. Among authors: shih hm. J Surg Res. 2013 Jan;179(1):138-44. doi: 10.1016/j.jss.2012.09.013. Epub 2012 Oct 10. J Surg Res. 2013. PMID: 23122667
Although the report demonstrated that the procedure may result in less favorable long-term outcomes despite the decrease in intracranial pressure and shorter length of intensive care unit stay, the study has been criticized, and the debate is still inconclusive partly beca …
Although the report demonstrated that the procedure may result in less favorable long-term outcomes despite the decrease in intracran …