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Basolateral amygdala response to food cues in the absence of hunger is associated with weight gain susceptibility.
Sun X, Kroemer NB, Veldhuizen MG, Babbs AE, de Araujo IE, Gitelman DR, Sherwin RS, Sinha R, Small DM. Sun X, et al. Among authors: sherwin rs. J Neurosci. 2015 May 20;35(20):7964-76. doi: 10.1523/JNEUROSCI.3884-14.2015. J Neurosci. 2015. PMID: 25995480 Free PMC article.
This behavior is disrupted by the disconnection of amygdala pathways to the lateral hypothalamus (Petrovich et al., 2002). Whether this circuit contributes to long-term weight gain is unknown. Using fMRI in 32 healthy individuals, we demonstrate here that the amygdala resp …
This behavior is disrupted by the disconnection of amygdala pathways to the lateral hypothalamus (Petrovich et al., 2002). Whether this circ …
Increased brain transport and metabolism of acetate in hypoglycemia unawareness.
Gulanski BI, De Feyter HM, Page KA, Belfort-DeAguiar R, Mason GF, Rothman DL, Sherwin RS. Gulanski BI, et al. Among authors: sherwin rs. J Clin Endocrinol Metab. 2013 Sep;98(9):3811-20. doi: 10.1210/jc.2013-1701. Epub 2013 Jun 24. J Clin Endocrinol Metab. 2013. PMID: 23796565 Free PMC article.
CONTEXT: Intensive insulin therapy reduces the risk for long-term complications in patients with type 1 diabetes mellitus (T1DM) but increases the risk for hypoglycemia-associated autonomic failure (HAAF), a syndrome that includes hypoglycemia unawareness and defective glu …
CONTEXT: Intensive insulin therapy reduces the risk for long-term complications in patients with type 1 diabetes mellitus (T1DM) but …
Long-term, intermittent, insulin-induced hypoglycemia produces marked obesity without hyperphagia or insulin resistance: a model for weight gain with intensive insulin therapy.
McNay EC, Teske JA, Kotz CM, Dunn-Meynell A, Levin BE, McCrimmon RJ, Sherwin RS. McNay EC, et al. Among authors: sherwin rs. Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E131-8. doi: 10.1152/ajpendo.00262.2012. Epub 2012 Nov 20. Am J Physiol Endocrinol Metab. 2013. PMID: 23169787 Free PMC article.
Diabetes. Can tight glycemic control in diabetes benefit cognition?
Herzog RI, Sherwin RS. Herzog RI, et al. Among authors: sherwin rs. Nat Rev Neurol. 2012 Jan 31;8(3):124-6. doi: 10.1038/nrneurol.2012.10. Nat Rev Neurol. 2012. PMID: 22290574 Free PMC article.
Intensive glucose management, if begun early, diminishes the long-term complications of diabetes. Whether the cognitive domain also benefits from such therapy is not clear, and has remained subject to investigation. ...
Intensive glucose management, if begun early, diminishes the long-term complications of diabetes. Whether the cognitive domain also b …
Ghrelin controls hippocampal spine synapse density and memory performance.
Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschöp MH, Horvath TL. Diano S, et al. Among authors: sherwin rs. Nat Neurosci. 2006 Mar;9(3):381-8. doi: 10.1038/nn1656. Epub 2006 Feb 19. Nat Neurosci. 2006. PMID: 16491079
Here we report that circulating ghrelin enters the hippocampus and binds to neurons of the hippocampal formation, where it promotes dendritic spine synapse formation and generation of long-term potentiation. These ghrelin-induced synaptic changes are paralleled by enhanced …
Here we report that circulating ghrelin enters the hippocampus and binds to neurons of the hippocampal formation, where it promotes dendriti …
Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats.
McNay EC, Sherwin RS. McNay EC, et al. Among authors: sherwin rs. Diabetes. 2004 Feb;53(2):418-25. doi: 10.2337/diabetes.53.2.418. Diabetes. 2004. PMID: 14747293
We used a model of RH in nondiabetic and diabetic rats to examine the effects of short-term (3 h daily for 3 days) RH on subsequent hippocampally dependent spatial memory, tested either at euglycemia or under acute hypoglycemia. ...
We used a model of RH in nondiabetic and diabetic rats to examine the effects of short-term (3 h daily for 3 days) RH on subsequent h …
Brain glucose levels are elevated in chronically hyperglycemic diabetic rats: no evidence for protective adaptation by the blood brain barrier.
Jacob RJ, Fan X, Evans ML, Dziura J, Sherwin RS. Jacob RJ, et al. Among authors: sherwin rs. Metabolism. 2002 Dec;51(12):1522-4. doi: 10.1053/meta.2002.36347. Metabolism. 2002. PMID: 12489061
Hence, brain tissue may be chronically exposed to markedly elevated levels of glucose and other metabolic fuels during poorly controlled diabetes, and therefore it may be subject to the same long-term adverse effects of hyperglycemia seen in peripheral tissues....
Hence, brain tissue may be chronically exposed to markedly elevated levels of glucose and other metabolic fuels during poorly controlled dia …
Effects of methyltestosterone on insulin secretion and sensitivity in women.
Diamond MP, Grainger D, Diamond MC, Sherwin RS, Defronzo RA. Diamond MP, et al. Among authors: sherwin rs. J Clin Endocrinol Metab. 1998 Dec;83(12):4420-5. doi: 10.1210/jcem.83.12.5333. J Clin Endocrinol Metab. 1998. PMID: 9851788
The frequent coexistence of hyperandrogenism and insulin resistance is well established; however, whether a cause and effect relationship exists remains to be established. In this study we tested the hypothesis that short-term androgen administered to women would induce in …
The frequent coexistence of hyperandrogenism and insulin resistance is well established; however, whether a cause and effect relationship ex …
Peroral gene therapy of lactose intolerance using an adeno-associated virus vector.
During MJ, Xu R, Young D, Kaplitt MG, Sherwin RS, Leone P. During MJ, et al. Among authors: sherwin rs. Nat Med. 1998 Oct;4(10):1131-5. doi: 10.1038/2625. Nat Med. 1998. PMID: 9771745
Gene therapy is usually reserved for severe and medically refractory disorders because of the toxicity, potential long-term risks and invasiveness of most gene transfer protocols. Here we show that an orally administered adeno-associated viral vector leads to persistent ex …
Gene therapy is usually reserved for severe and medically refractory disorders because of the toxicity, potential long-term risks and …
19 results