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When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?
Wu Y, Allegaert K, Flint RB, Goulooze SC, Välitalo PAJ, de Hoog M, Mulla H, Sherwin CMT, Simons SHP, Krekels EHJ, Knibbe CAJ, Völler S. Wu Y, et al. Among authors: sherwin cmt. Pharm Res. 2024 Apr;41(4):637-649. doi: 10.1007/s11095-024-03677-3. Epub 2024 Mar 12. Pharm Res. 2024. PMID: 38472610 Free PMC article.
AIMS: Whether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation model for (pre)term-born individuals from birth to 18 years of age. ...We developed a GFR function consistin …
AIMS: Whether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop …
Treatment optimization of maintenance immunosuppressive agents in pediatric renal transplant recipients.
Job KM, Roberts JK, Enioutina EY, Illamola SM, Kumar SS, Rashid J, Ward RM, Fukuda T, Sherbotie J, Sherwin CM. Job KM, et al. Among authors: sherwin cm. Expert Opin Drug Metab Toxicol. 2021 Jul;17(7):747-765. doi: 10.1080/17425255.2021.1943356. Epub 2021 Jun 29. Expert Opin Drug Metab Toxicol. 2021. PMID: 34121566 Free PMC article. Review.
Despite these developments in graft survival for patients, there is still improvement needed, particularly in long-term care in pediatric patients receiving grafts from deceased donor patients. ...
Despite these developments in graft survival for patients, there is still improvement needed, particularly in long-term care in pedia …
Population Pharmacokinetic Modeling in the Presence of Missing Time-Dependent Covariates: Impact of Body Weight on Pharmacokinetics of Paracetamol in Neonates.
Krzyzanski W, Cook SF, Wilbaux M, Sherwin CMT, Allegaert K, Vermeulen A, van den Anker JN. Krzyzanski W, et al. Among authors: sherwin cmt. AAPS J. 2019 May 28;21(4):68. doi: 10.1208/s12248-019-0331-0. AAPS J. 2019. PMID: 31140019 Free PMC article.
The objective of this study is to determine if missing body weights in preterm and term neonates affect estimates of model parameters and which methods can be used to improve performance of a population pharmacokinetic model of paracetamol. ...
The objective of this study is to determine if missing body weights in preterm and term neonates affect estimates of model parameters …
Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target.
Bhongsatiern J, Stockmann C, Roberts JK, Yu T, Korgenski KE, Spigarelli MG, Desai PB, Sherwin CM. Bhongsatiern J, et al. Among authors: sherwin cm. Ther Drug Monit. 2015 Dec;37(6):756-65. doi: 10.1097/FTD.0000000000000216. Ther Drug Monit. 2015. PMID: 26562817 Free PMC article.
AIM: To develop a vancomycin population pharmacokinetic model and assess the probability of attaining a pharmacodynamic target associated with clinical and microbiological success, a ratio of the 24-hour area under the concentration-time curve to the minimum inhibitory concentrat …
AIM: To develop a vancomycin population pharmacokinetic model and assess the probability of attaining a pharmacodynamic target associated wi …
Population Pharmacokinetics of Intravenous Paracetamol (Acetaminophen) in Preterm and Term Neonates: Model Development and External Evaluation.
Cook SF, Roberts JK, Samiee-Zafarghandy S, Stockmann C, King AD, Deutsch N, Williams EF, Allegaert K, Wilkins DG, Sherwin CM, van den Anker JN. Cook SF, et al. Among authors: sherwin cm. Clin Pharmacokinet. 2016 Jan;55(1):107-19. doi: 10.1007/s40262-015-0301-3. Clin Pharmacokinet. 2016. PMID: 26201306 Free PMC article.
OBJECTIVES: The aims of this study were to develop a population pharmacokinetic model for intravenous paracetamol in preterm and term neonates and to assess the generalizability of the model by testing its predictive performance in an external dataset. ...CONCLUSIONS: Weig …
OBJECTIVES: The aims of this study were to develop a population pharmacokinetic model for intravenous paracetamol in preterm and term …
Neonatal magnesium levels correlate with motor outcomes in premature infants: a long-term retrospective cohort study.
Doll E, Wilkes J, Cook LJ, Korgenski EK, Faix RG, Yoder BA, Srivastava R, Sherwin CM, Spigarelli MG, Clark EA, Bonkowsky JL. Doll E, et al. Among authors: sherwin cm. Front Pediatr. 2014 Nov 5;2:120. doi: 10.3389/fped.2014.00120. eCollection 2014. Front Pediatr. 2014. PMID: 25414842 Free PMC article.
Our objective was to determine whether higher neonatal serum magnesium levels were associated with better long-term neurodevelopmental outcomes in very-low birth weight infants. ...CONCLUSION: This study demonstrates a correlation between higher neonatal magnesium l …
Our objective was to determine whether higher neonatal serum magnesium levels were associated with better long-term neurodevelopmenta …
Development of an optimal sampling schedule for children receiving ketamine for short-term procedural sedation and analgesia.
Sherwin CM, Stockmann C, Grimsrud K, Herd DW, Anderson BJ, Spigarelli MG. Sherwin CM, et al. Paediatr Anaesth. 2015 Feb;25(2):211-6. doi: 10.1111/pan.12521. Epub 2014 Sep 12. Paediatr Anaesth. 2015. PMID: 25212712
CONCLUSION: An optimal sampling schedule was developed that allowed assessment of the pharmacokinetic parameters of ketamine among children requiring short-term procedural sedation....
CONCLUSION: An optimal sampling schedule was developed that allowed assessment of the pharmacokinetic parameters of ketamine among children …
Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration.
De Cock RF, Allegaert K, Brussee JM, Sherwin CM, Mulla H, de Hoog M, van den Anker JN, Danhof M, Knibbe CA. De Cock RF, et al. Among authors: sherwin cm. Pharm Res. 2014 Oct;31(10):2643-54. doi: 10.1007/s11095-014-1361-z. Epub 2014 May 2. Pharm Res. 2014. PMID: 24789450 Free PMC article.
Population clearance values (Cldrug) for gentamicin, tobramycin and vancomycin were 0.21, 0.28 and 0.39 L/h for a full term neonate of 4 kg, respectively. DISCUSSION: Based on an integrated analysis of gentamicin, tobramycin and vancomycin, a semi-physiological function fo …
Population clearance values (Cldrug) for gentamicin, tobramycin and vancomycin were 0.21, 0.28 and 0.39 L/h for a full term neonate o …
Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity.
Schoen K, Yu T, Stockmann C, Spigarelli MG, Sherwin CM. Schoen K, et al. Among authors: sherwin cm. Paediatr Drugs. 2014 Apr;16(2):169-77. doi: 10.1007/s40272-013-0063-z. Paediatr Drugs. 2014. PMID: 24399614 Free PMC article. Review.
Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more than 80 % of neonates with a birth weight less than 1,000 g. ...When used as a therapeutic agent, larger doses of caffeine citrate have been shown to improve acute neonatal outc …
Apnea of prematurity (AOP) is a common complication of preterm birth, which affects more than 80 % of neonates with a birth we …
Considerations in the pharmacologic treatment and prevention of neonatal sepsis.
Stockmann C, Spigarelli MG, Campbell SC, Constance JE, Courter JD, Thorell EA, Olson J, Sherwin CM. Stockmann C, et al. Among authors: sherwin cm. Paediatr Drugs. 2014 Feb;16(1):67-81. doi: 10.1007/s40272-013-0057-x. Paediatr Drugs. 2014. PMID: 24218112 Review.
Antifungal prophylaxis with fluconazole has also been reported to dramatically reduce rates of neonatal invasive fungal infections and to improve long-term neurodevelopmental outcomes among treated children. Additionally, several large multicenter studies are currently inv …
Antifungal prophylaxis with fluconazole has also been reported to dramatically reduce rates of neonatal invasive fungal infections and to im …
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