TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice.
Chen S, Peng J, Sherchan P, Ma Y, Xiang S, Yan F, Zhao H, Jiang Y, Wang N, Zhang JH, Zhang H.
Chen S, et al. Among authors: sherchan p.
J Neuroinflammation. 2020 May 28;17(1):168. doi: 10.1186/s12974-020-01853-x.
J Neuroinflammation. 2020.
PMID: 32466767
Free PMC article.
TREM2 was expressed on microglia, astrocytes, and neurons. COG1410 improved both short-term and long-term neurological functions, reduced brain edema, inhibited microglia/macrophage activation and neutrophil infiltration, and suppressed neuronal apoptotic cell death …
TREM2 was expressed on microglia, astrocytes, and neurons. COG1410 improved both short-term and long-term neurological functio …