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UDP-Glucose/P2Y14 Receptor Signaling Exacerbates Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats.
Kanamaru H, Zhu S, Dong S, Takemoto Y, Huang L, Sherchan P, Suzuki H, Tang J, Zhang JH. Kanamaru H, et al. Among authors: sherchan p. Stroke. 2024 May;55(5):1381-1392. doi: 10.1161/STROKEAHA.123.044422. Epub 2024 Mar 25. Stroke. 2024. PMID: 38525592
Although P2Y14 inhibitor decreased neurological dysfunction, neuronal apoptosis, and proapoptotic molecules, exogenous UDP-G exacerbated these outcomes at 24 hours after SAH. Early inhibition of P2Y14 preserved long-term neuronal survival in the hippocampus, amygdala, and …
Although P2Y14 inhibitor decreased neurological dysfunction, neuronal apoptosis, and proapoptotic molecules, exogenous UDP-G exacerbated the …
Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage.
Flores JJ, Ding Y, Sherchan P, Zhang JH, Tang J. Flores JJ, et al. Among authors: sherchan p. Exp Neurol. 2023 Jan;359:114257. doi: 10.1016/j.expneurol.2022.114257. Epub 2022 Oct 21. Exp Neurol. 2023. PMID: 36279933 Free PMC article.
AnxA1 and FPR2 Inhibitor (Boc2) were given at 1-h post-GMH via intranasal administration. FPR2 CRISPR was given 48-h prior to GMH induction. Short-term neurological deficits were assessed using negative geotaxis test. ...We have demonstrated that AnxA1 treatment enhances h …
AnxA1 and FPR2 Inhibitor (Boc2) were given at 1-h post-GMH via intranasal administration. FPR2 CRISPR was given 48-h prior to GMH induction. …
Kynurenine/Aryl Hydrocarbon Receptor Modulates Mitochondria-Mediated Oxidative Stress and Neuronal Apoptosis in Experimental Intracerebral Hemorrhage.
Ren R, Fang Y, Sherchan P, Lu Q, Lenahan C, Zhang JH, Zhang J, Tang J. Ren R, et al. Among authors: sherchan p. Antioxid Redox Signal. 2022 Dec;37(16-18):1111-1129. doi: 10.1089/ars.2021.0215. Epub 2022 Nov 2. Antioxid Redox Signal. 2022. PMID: 35481813 Free PMC article.
The ICH insult resulted in an increase of total and nucleus AHR protein levels and AHR transcriptional activity. Inhibition of AHR provided both short- and long- term neurological benefits by attenuating mitochondria-mediated oxidative stress and neuronal apoptosis after I …
The ICH insult resulted in an increase of total and nucleus AHR protein levels and AHR transcriptional activity. Inhibition of AHR provided …
Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice.
Deng S, Jin P, Sherchan P, Liu S, Cui Y, Huang L, Zhang JH, Gong Y, Tang J. Deng S, et al. Among authors: sherchan p. J Neuroinflammation. 2021 Mar 1;18(1):62. doi: 10.1186/s12974-021-02112-3. J Neuroinflammation. 2021. PMID: 33648537 Free PMC article.
CCR4 was found to co-localize with microglia, neurons, and astrocytes. rCCL17 treatment decreased brain water content, attenuated short- and long-term neurological deficits, deceased activation of microglia/macrophages and infiltration of neutrophils, and inhibited neurona …
CCR4 was found to co-localize with microglia, neurons, and astrocytes. rCCL17 treatment decreased brain water content, attenuated short- and …
Surgically-induced brain injury: where are we now?
Travis ZD, Sherchan P, Hayes WK, Zhang JH. Travis ZD, et al. Among authors: sherchan p. Chin Neurosurg J. 2019 Dec 16;5:29. doi: 10.1186/s41016-019-0181-8. eCollection 2019. Chin Neurosurg J. 2019. PMID: 32922928 Free PMC article. Review.
Incisions, retraction, thermal damage from electrocautery, and intraoperative hemorrhage cause immediate and long-term brain injuries that are directly linked to neurosurgical operations, and these types of injuries, collectively, have been termed surgical brain injury (SB …
Incisions, retraction, thermal damage from electrocautery, and intraoperative hemorrhage cause immediate and long-term brain injuries …
Recombinant CCL17 Enhances Hematoma Resolution and Activation of CCR4/ERK/Nrf2/CD163 Signaling Pathway After Intracerebral Hemorrhage in Mice.
Deng S, Sherchan P, Jin P, Huang L, Travis Z, Zhang JH, Gong Y, Tang J. Deng S, et al. Among authors: sherchan p. Neurotherapeutics. 2020 Oct;17(4):1940-1953. doi: 10.1007/s13311-020-00908-4. Neurotherapeutics. 2020. PMID: 32783091 Free PMC article.
Clustered regularly interspaced short palindromic repeats (CRISPR) knockout for CD163 was administered by intracerebroventricular injection at 48 h before ICH. Brain edema, short- and long-term neurobehavior evaluation, hematoma volume, hemoglobin content, western blot, an …
Clustered regularly interspaced short palindromic repeats (CRISPR) knockout for CD163 was administered by intracerebroventricular injection …
Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice.
Li T, Xu W, Ouyang J, Lu X, Sherchan P, Lenahan C, Irio G, Zhang JH, Zhao J, Zhang Y, Tang J. Li T, et al. Among authors: sherchan p. J Neuroinflammation. 2020 Jun 15;17(1):187. doi: 10.1186/s12974-020-01841-1. J Neuroinflammation. 2020. PMID: 32539736 Free PMC article.
Expression of OXA decreased whereas OXR1 and OXR2 increased after ICH. OXA treatment significantly improved not only short-term but also long-term neurofunctional outcomes and reduced brain edema in ipsilateral hemisphere. ...
Expression of OXA decreased whereas OXR1 and OXR2 increased after ICH. OXA treatment significantly improved not only short-term but a …
TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice.
Chen S, Peng J, Sherchan P, Ma Y, Xiang S, Yan F, Zhao H, Jiang Y, Wang N, Zhang JH, Zhang H. Chen S, et al. Among authors: sherchan p. J Neuroinflammation. 2020 May 28;17(1):168. doi: 10.1186/s12974-020-01853-x. J Neuroinflammation. 2020. PMID: 32466767 Free PMC article.
TREM2 was expressed on microglia, astrocytes, and neurons. COG1410 improved both short-term and long-term neurological functions, reduced brain edema, inhibited microglia/macrophage activation and neutrophil infiltration, and suppressed neuronal apoptotic cell death …
TREM2 was expressed on microglia, astrocytes, and neurons. COG1410 improved both short-term and long-term neurological functio …
Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats.
Zhuang K, Zuo YC, Sherchan P, Wang JK, Yan XX, Liu F. Zhuang K, et al. Among authors: sherchan p. Front Neurosci. 2020 Jan 21;13:1441. doi: 10.3389/fnins.2019.01441. eCollection 2019. Front Neurosci. 2020. PMID: 32038143 Free PMC article.
Hydrogen inhalation reduced the expression of these inflammatory and apoptotic makers in the vessels, brain edema, microthrombi formation, and vasospasm in rats with SAH relative to control. Hydrogen inhalation also improved short-term and long-term neurological rec …
Hydrogen inhalation reduced the expression of these inflammatory and apoptotic makers in the vessels, brain edema, microthrombi formation, a …
Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model.
Zakhary G, Sherchan P, Li Q, Tang J, Zhang JH. Zakhary G, et al. Among authors: sherchan p. J Neurosci Res. 2020 Jan;98(1):155-167. doi: 10.1002/jnr.24489. Epub 2019 Jun 30. J Neurosci Res. 2020. PMID: 31257634 Free PMC article.
Treatment with RO 61-8048 (40 mg/kg) reduced brain water content and improved long-term neurological function after SBI. RO 61-8048 increased the expression of kynurenic acid while reducing QUIN and apoptotic markers in the surrounding brain tissue after SBI. ...
Treatment with RO 61-8048 (40 mg/kg) reduced brain water content and improved long-term neurological function after SBI. RO 61-8048 i …
15 results