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Hemodynamic Effects of the Osmopressor Response: A Systematic Review and Meta-Analysis.
Oyewunmi OA, Lei LY, Laurin JKH, Morillo CA, Sheldon RS, Raj SR. Oyewunmi OA, et al. Among authors: sheldon rs. J Am Heart Assoc. 2023 Nov 7;12(21):e029645. doi: 10.1161/JAHA.122.029645. Epub 2023 Nov 6. J Am Heart Assoc. 2023. PMID: 37929748 Free PMC article.
Conclusions In patients with orthostatic hypotension, rapid water intake elevated short-term systolic BP and diastolic BP, with mild HR reduction when seated or supine. ...
Conclusions In patients with orthostatic hypotension, rapid water intake elevated short-term systolic BP and diastolic BP, with mild …
Canadian Cardiovascular Society 2023 Guidelines on the Fitness to Drive.
Co-chairs:; Guerra PG, Simpson CS, Van Spall HGC; Writing Panel:; Asgar AW, Billia P, Cadrin-Tourigny J, Chakrabarti S, Cheung CC, Dore A, Fordyce CB, Gouda P, Hassan A, Krahn A, Luc JGY, Mak S, McMurtry S, Norris C, Philippon F, Sapp J, Sheldon R, Silversides C, Steinberg C, Wood DA. Co-chairs:, et al. Among authors: sheldon r. Can J Cardiol. 2024 Apr;40(4):500-523. doi: 10.1016/j.cjca.2023.09.033. Epub 2023 Oct 10. Can J Cardiol. 2024. PMID: 37820870
We suggest appropriate waiting times after cardiac interventions or acute illnesses before driving resumption. When short-term driving cessation is recommended, recommendations are on the basis of expert consensus rather than the Risk of Harm formula because risk elevation …
We suggest appropriate waiting times after cardiac interventions or acute illnesses before driving resumption. When short-term drivin …
A rapid microglial metabolic response controls metabolism and improves memory.
Drougard A, Ma EH, Wegert V, Sheldon R, Panzeri I, Vatsa N, Apostle S, Fagnocchi L, Schaf J, Gossens K, Völker J, Pang S, Bremser A, Dror E, Giacona F, Sagar, Henderson MX, Prinz M, Jones RG, Pospisilik JA. Drougard A, et al. Among authors: sheldon r. bioRxiv [Preprint]. 2023 Apr 4:2023.04.03.535373. doi: 10.1101/2023.04.03.535373. bioRxiv. 2023. PMID: 37066282 Free PMC article. Preprint.
Together, these data identify microglial cells as a critical nutrient regulatory node in the brain, metabolizing away harmful fatty acids and liberating the same carbons instead as alternate bioenergetic and protective substrates. The data identify a surprisingly beneficial effec …
Together, these data identify microglial cells as a critical nutrient regulatory node in the brain, metabolizing away harmful fatty acids an …
Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19.
Hira R, Baker JR, Siddiqui T, Ranada SI, Soroush A, Karalasingham K, Ahmad H, Mavai V, Ayala Valani LM, Ambreen S, Bourne KM, Lloyd MG, Morillo CA, Sheldon RS, Raj SR; Canadian Long COVID Autonomic Network (CanLoCAN). Hira R, et al. Among authors: sheldon rs. Can J Cardiol. 2023 Jun;39(6):767-775. doi: 10.1016/j.cjca.2022.12.002. Epub 2022 Dec 9. Can J Cardiol. 2023. PMID: 36509178 Free PMC article.
Finally, even nonhospitalized "mild" infections can result in long-term CAAs....
Finally, even nonhospitalized "mild" infections can result in long-term CAAs....
Current approach to the treatment of vasovagal syncope in adults.
Hatoum T, Raj S, Sheldon RS. Hatoum T, et al. Among authors: sheldon rs. Intern Emerg Med. 2023 Jan;18(1):23-30. doi: 10.1007/s11739-022-03102-w. Epub 2022 Sep 18. Intern Emerg Med. 2023. PMID: 36117230 Review.
Physical counterpressure maneuvers might be helpful but can be of limited efficacy in older patients and those with short or no prodromes. Orthostatic training lacks long term efficacy and is troubled by non-compliance. Yoga might be helpful, although the biomedical mechan …
Physical counterpressure maneuvers might be helpful but can be of limited efficacy in older patients and those with short or no prodromes. O …
A Rational Evaluation of the Syncope Patient: Optimizing the Emergency Department Visit.
Hatoum T, Sheldon RS. Hatoum T, et al. Among authors: sheldon rs. Medicina (Kaunas). 2021 May 21;57(6):514. doi: 10.3390/medicina57060514. Medicina (Kaunas). 2021. PMID: 34064050 Free PMC article. Review.
We will outline a structured approach to the syncope patient in the emergency department, highlighting the evidence supporting the role of clinical judgement and the initial electrocardiogram (ECG) in making the preliminary diagnosis and in safely identifying the patients at low …
We will outline a structured approach to the syncope patient in the emergency department, highlighting the evidence supporting the role of c …
Ambulance Use, Health Outcomes, and Costs for Emergency Department Visits for Primary Diagnosis of Syncope in Canada.
Gupta AK, Savu A, Sheldon RS, Raj SR, Kaul P, Sandhu RK. Gupta AK, et al. Among authors: sheldon rs. CJC Open. 2020 May 12;2(5):365-369. doi: 10.1016/j.cjco.2020.04.012. eCollection 2020 Sep. CJC Open. 2020. PMID: 32995722 Free PMC article.
CONCLUSION: A majority of syncope patients arrived to the ED by ambulance, and over 3 quarters were directly discharged home. Although discharged patients had a favourable short-term prognosis, they incurred high transportation costs. Strategies aimed at preventing unneces …
CONCLUSION: A majority of syncope patients arrived to the ED by ambulance, and over 3 quarters were directly discharged home. Although disch …
Biocatalysis and biomass conversion: enabling a circular economy.
Sheldon RA. Sheldon RA. Philos Trans A Math Phys Eng Sci. 2020 Jul 24;378(2176):20190274. doi: 10.1098/rsta.2019.0274. Epub 2020 Jul 6. Philos Trans A Math Phys Eng Sci. 2020. PMID: 32623984
Additionally, they are derived from inexpensive renewable resources which are readily available and not subject to the large price fluctuations which undermine the long-term commercial viability of scarce precious metal catalysts. Thanks to spectacular advances in molecula …
Additionally, they are derived from inexpensive renewable resources which are readily available and not subject to the large price fluctuati …
Stemming the Tide of Opioid Addiction-Dramatic Reductions in Postoperative Opioid Requirements Through Preoperative Education and a Standardized Analgesic Regimen.
Sheldon RR, Weiss JB, Do WS, Forte DM, Carter PL, Eckert MJ, Sohn VY. Sheldon RR, et al. Mil Med. 2020 Mar 2;185(3-4):436-443. doi: 10.1093/milmed/usz279. Mil Med. 2020. PMID: 31621868
INTRODUCTION: Surgery is a known gateway to opioid use that may result in long-term morbidity. Given the paucity of evidence regarding the appropriate amount of postoperative opioid analgesia and variable prescribing education, we investigated prescribing habits before and …
INTRODUCTION: Surgery is a known gateway to opioid use that may result in long-term morbidity. Given the paucity of evidence regardin …
Strain-Related Differences in Mouse Neonatal Hypoxia-Ischemia.
Sheldon RA, Windsor C, Ferriero DM. Sheldon RA, et al. Dev Neurosci. 2018;40(5-6):490-496. doi: 10.1159/000495880. Epub 2019 Feb 28. Dev Neurosci. 2018. PMID: 30820007 Free PMC article.
Recently, the P9 or P10 mouse brain was recognized as the developmental equivalent of a term neonatal human brain, rather than P7. Consequently, the Vannucci procedure has again been modified, and a commonly used protocol employs 10% oxygen for 50 min in C57Bl/6 mice. ...
Recently, the P9 or P10 mouse brain was recognized as the developmental equivalent of a term neonatal human brain, rather than P7. Co …
35 results