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Association of Elevated Body Mass Index with Functional Outcome and Mortality following Acute Ischemic Stroke: The Obesity Paradox Revisited.
Dicpinigaitis AJ, Palumbo KE, Gandhi CD, Cooper JB, Hanft S, Kamal H, Shapiro SD, Feldstein E, Kafina M, Kurian C, Chong JY, Mayer SA, Al-Mufti F. Dicpinigaitis AJ, et al. Among authors: shapiro sd. Cerebrovasc Dis. 2022;51(5):565-569. doi: 10.1159/000521513. Epub 2022 Feb 14. Cerebrovasc Dis. 2022. PMID: 35158366
CONCLUSION: This cross-sectional analysis demonstrates a lower likelihood of discharge to home as well as in-hospital mortality in obese patients following AIS, suggestive of a protective effect of obesity against mortality but not against all poststroke neurological deficits in …
CONCLUSION: This cross-sectional analysis demonstrates a lower likelihood of discharge to home as well as in-hospital mortality in obese pat …
Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis.
Bakalov V, Reyes-Uribe L, Deshpande R, Maloy AL, Shapiro SD, Angus DC, Chang CH, Le Moyec L, Wendell SG, Kaynar AM. Bakalov V, et al. Among authors: shapiro sd. PLoS One. 2020 Nov 5;15(11):e0241122. doi: 10.1371/journal.pone.0241122. eCollection 2020. PLoS One. 2020. PMID: 33151963 Free PMC article.
Sepsis is the leading cause of death in hospitalized patients and beyond the hospital stay and these long-term sequelae are due in part to unresolved inflammation. Metabolic shift from oxidative phosphorylation to aerobic glycolysis links metabolism to inflammation and suc …
Sepsis is the leading cause of death in hospitalized patients and beyond the hospital stay and these long-term sequelae are due in pa …
Effects of intra-abdominal sepsis on atherosclerosis in mice.
Kaynar AM, Yende S, Zhu L, Frederick DR, Chambers R, Burton CL, Carter M, Stolz DB, Agostini B, Gregory AD, Nagarajan S, Shapiro SD, Angus DC. Kaynar AM, et al. Among authors: shapiro sd. Crit Care. 2014 Sep 3;18(5):469. doi: 10.1186/s13054-014-0469-1. Crit Care. 2014. PMID: 25182529 Free PMC article.
These findings support observations in humans and demonstrate the feasibility of a long-term follow-up murine model of sepsis....
These findings support observations in humans and demonstrate the feasibility of a long-term follow-up murine model of sepsis....
Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury.
Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, Shapiro SD, Cataltepe S. Hirakawa H, et al. Among authors: shapiro sd. Am J Respir Crit Care Med. 2007 Oct 15;176(8):778-85. doi: 10.1164/rccm.200704-519OC. Epub 2007 Aug 2. Am J Respir Crit Care Med. 2007. PMID: 17673697 Free PMC article.
RATIONALE: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. ...
RATIONALE: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as …
CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.
Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD. Maeno T, et al. Among authors: shapiro sd. J Immunol. 2007 Jun 15;178(12):8090-6. doi: 10.4049/jimmunol.178.12.8090. J Immunol. 2007. PMID: 17548647
In contrast to wild-type C57BL/6J mice that displayed macrophage, lymphocyte, and neutrophil recruitment to the lung followed by emphysema in response to cigarette smoke, CD8+ T cell-deficient (CD8-/-) mice had a blunted inflammatory response and did not develop emphysema when ex …
In contrast to wild-type C57BL/6J mice that displayed macrophage, lymphocyte, and neutrophil recruitment to the lung followed by emphysema i …
Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure.
Buckley C, Wyble CW, Borhani M, Ennis TL, Kobayashi DK, Curci JA, Shapiro SD, Thompson RW. Buckley C, et al. Among authors: shapiro sd. J Am Coll Surg. 2004 Dec;199(6):896-903. doi: 10.1016/j.jamcollsurg.2004.08.010. J Am Coll Surg. 2004. PMID: 15555973 Free article.

Although all animals had developed AAAs by 12 weeks after elastase perfusion, the overall extent of aortic dilatation was 50% greater in smoking mice compared with nonsmoking controls (Delta AD smoking, 204 +/- 23% versus nonsmoking, 135 +/- 17%; p < 0.05). CONCLUSIONS: Short-

…
Although all animals had developed AAAs by 12 weeks after elastase perfusion, the overall extent of aortic dilatation was 50% greater in smo …
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
Shapiro SD, Goldstein NM, Houghton AM, Kobayashi DK, Kelley D, Belaaouaj A. Shapiro SD, et al. Am J Pathol. 2003 Dec;163(6):2329-35. doi: 10.1016/S0002-9440(10)63589-4. Am J Pathol. 2003. PMID: 14633606 Free PMC article.
To address the role of neutrophil elastase in pulmonary emphysema, neutrophil elastase-deficient mice and wild-type littermate controls were exposed to long-term cigarette smoke. Compared to wild-type littermates, mice that were deficient in neutrophil elastase were signif …
To address the role of neutrophil elastase in pulmonary emphysema, neutrophil elastase-deficient mice and wild-type littermate controls were …
Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice.
Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Hautamaki RD, et al. Among authors: shapiro sd. Science. 1997 Sep 26;277(5334):2002-4. doi: 10.1126/science.277.5334.2002. Science. 1997. PMID: 9302297
In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME-/- mice that received monthly intratracheal instillations of monocy …
In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in res …
Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression.
Belaaouaj A, Shipley JM, Kobayashi DK, Zimonjic DB, Popescu N, Silverman GA, Shapiro SD. Belaaouaj A, et al. Among authors: shapiro sd. J Biol Chem. 1995 Jun 16;270(24):14568-75. doi: 10.1074/jbc.270.24.14568. J Biol Chem. 1995. PMID: 7782320 Free article.
HME mRNA is not detectable in normal adult tissues but is induced in rapidly remodeling tissues such as the term placenta. In situ hybridization and immunohistochemistry of placental tissue demonstrated HME mRNA and protein expression in macrophages and stromal cells. ...
HME mRNA is not detectable in normal adult tissues but is induced in rapidly remodeling tissues such as the term placenta. In situ hy …
Prospective study of long-term pulmonary manifestations of mantle irradiation.
Shapiro SJ, Shapiro SD, Mill WB, Campbell EJ. Shapiro SJ, et al. Among authors: shapiro sd. Int J Radiat Oncol Biol Phys. 1990 Sep;19(3):707-14. doi: 10.1016/0360-3016(90)90500-j. Int J Radiat Oncol Biol Phys. 1990. PMID: 2211219
Prior studies of patients receiving mantle irradiation demonstrated short-term (up to 24 months) abnormalities of pulmonary function. In the present study, we prospectively studied 13 patients for up to 60 months after irradiation only with serial pulmonary function tests, …
Prior studies of patients receiving mantle irradiation demonstrated short-term (up to 24 months) abnormalities of pulmonary function. …
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