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Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.
Rheault MN, Alpers CE, Barratt J, Bieler S, Canetta P, Chae DW, Coppock G, Diva U, Gesualdo L, Heerspink HJL, Inrig JK, Kirsztajn GM, Kohan D, Komers R, Kooienga LA, Lieberman K, Mercer A, Noronha IL, Perkovic V, Radhakrishnan J, Rote W, Rovin B, Tesar V, Trimarchi H, Tumlin J, Wong MG, Trachtman H; DUPRO Steering Committee and DUPLEX Investigators. Rheault MN, et al. N Engl J Med. 2023 Dec 28;389(26):2436-2445. doi: 10.1056/NEJMoa2308550. Epub 2023 Nov 3. N Engl J Med. 2023. PMID: 37921461 Clinical Trial.
In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The efficacy and safety of longer-term treatment with sparsentan for FSGS are unknown. METHODS: In this phase 3 trial, we enrolled patient …
In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The e …
Prognostic Value of Initial Diagnostic Imaging Findings for Patient Outcomes in Adult Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
Yu H, Ande SR, Batoo D, Linton J, Shankar J. Yu H, et al. Among authors: shankar j. Tomography. 2023 Feb 24;9(2):509-528. doi: 10.3390/tomography9020042. Tomography. 2023. PMID: 36961001 Free PMC article. Review.
INTRODUCTION: Termed the "silent epidemic," traumatic brain injury (TBI) is one of the greatest global contributors not only to post-traumatic death but also to post-traumatic long-term disability. This systematic review and meta-analysis aims to specifically evaluate the …
INTRODUCTION: Termed the "silent epidemic," traumatic brain injury (TBI) is one of the greatest global contributors not only to post-traumat …
Long term safety and effectiveness of LVIS Jr for treatment of intracranial aneurysms- a Canadian Multicenter registry.
McEachern J, Iancu D, van Adel B, Drake B, Kaderali Z, Spirou M, Lesiuk H, Weill A, Roy D, Raymond J, Hadziomerovic IS, Shankar J. McEachern J, et al. Among authors: shankar j. Interv Neuroradiol. 2023 Apr;29(2):134-140. doi: 10.1177/15910199221077588. Epub 2022 Feb 3. Interv Neuroradiol. 2023. PMID: 35112888 Free PMC article.
BACKGROUND: The Low-profile Visible Intraluminal Support device (LVIS Jr) has become a commonly used intracranial stent for the treatment of intracranial aneurysms. However long-term stability and effectiveness remains to be seen. The purpose of the study was to assess the …
BACKGROUND: The Low-profile Visible Intraluminal Support device (LVIS Jr) has become a commonly used intracranial stent for the treatment of …
Noninvasive Angiographic Results of Clipped or Coiled Intracranial Aneurysms: An Inter- and Intraobserver Reliability Study.
Benomar A, Farzin B, Gevry G, Boisseau W, Roy D, Weill A, Iancu D, Guilbert F, Létourneau-Guillon L, Jacquin G, Chaalala C, Bojanowski MW, Labidi M, Fahed R, Volders D, Nguyen TN, Gentric JC, Magro E, Boulouis G, Forestier G, Hak JF, Ghostine JS, Kaderali Z, Shankar JJ, Kotowski M, Darsaut TE, Raymond J. Benomar A, et al. Among authors: shankar jj. AJNR Am J Neuroradiol. 2021 Sep;42(9):1615-1620. doi: 10.3174/ajnr.A7236. Epub 2021 Jul 29. AJNR Am J Neuroradiol. 2021. PMID: 34326106 Free PMC article.
Raters were asked which angiographic grade and management decision (retreatment; close or long-term follow-up) would be most appropriate for each case. Agreement was analyzed using the Krippendorff alpha (alpha(K)) statistic, and the relationship between angiographic grade …
Raters were asked which angiographic grade and management decision (retreatment; close or long-term follow-up) would be most appropri …
Imaging Improves Efficacy of Vertebroplasty - A Systematic Review and Meta-Analysis.
Shankar JJS, Merdad R, Finitsis S, Parker R. Shankar JJS, et al. Can J Neurol Sci. 2019 Sep;46(5):540-549. doi: 10.1017/cjn.2019.236. Can J Neurol Sci. 2019. PMID: 31232247
Eight of the 10 studies (938 participants) that used imaging to confirm oedema in the target vertebral bodies showed PVA (compared to nonsurgical treatment) was effective in reducing pain (immediate term: mean difference (MD) of -1.89; 95% confidence interval -1.93 to -1.8 …
Eight of the 10 studies (938 participants) that used imaging to confirm oedema in the target vertebral bodies showed PVA (compared to nonsur …
Are Anterior Communicating Aneurysms Truly Anterior Communicating Aneurysms? An Observational Study.
Wong H, Banfield J, Hughes N, Shankar JJS. Wong H, et al. Among authors: shankar jjs. World Neurosurg. 2019 May;125:e1089-e1092. doi: 10.1016/j.wneu.2019.01.249. Epub 2019 Feb 18. World Neurosurg. 2019. PMID: 30790745
OBJECTIVE: The term anterior communicating (ACom) aneurysm is often broadly used to classify any aneurysm formed on the A1-A2 junction, A1, A2, or ACom arteries. ...
OBJECTIVE: The term anterior communicating (ACom) aneurysm is often broadly used to classify any aneurysm formed on the A1-A2 junctio …
Carbofuran hampers oligodendrocytes development leading to impaired myelination in the hippocampus of rat brain.
Seth B, Yadav A, Tandon A, Shankar J, Chaturvedi RK. Seth B, et al. Among authors: shankar j. Neurotoxicology. 2019 Jan;70:161-179. doi: 10.1016/j.neuro.2018.11.007. Epub 2018 Nov 22. Neurotoxicology. 2019. PMID: 30471306
Myelin is essential for efficient and rapid conduction of electric impulses and its loss in the hippocampus of the brain may result in impaired memory and long-term neurological deficits. Carbofuran, a carbamate pesticide is known to cause inhibition of hippocampal neuroge …
Myelin is essential for efficient and rapid conduction of electric impulses and its loss in the hippocampus of the brain may result in impai …
Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze.
Turi KN, Shankar J, Anderson LJ, Rajan D, Gaston K, Gebretsadik T, Das SR, Stone C, Larkin EK, Rosas-Salazar C, Brunwasser SM, Moore ML, Peebles RS Jr, Hartert TV. Turi KN, et al. Among authors: shankar j. Am J Respir Crit Care Med. 2018 Oct 15;198(8):1064-1073. doi: 10.1164/rccm.201711-2348OC. Am J Respir Crit Care Med. 2018. PMID: 29733679 Free PMC article.
OBJECTIVES: To identify nasal immune phenotypes in response to RSV infection and their association with recurrent wheeze. METHODS: A birth cohort of term healthy infants born June to December were recruited and followed to capture the first infant RSV infection. ...
OBJECTIVES: To identify nasal immune phenotypes in response to RSV infection and their association with recurrent wheeze. METHODS: A birt
Oral subchronic exposure to silver nanoparticles causes renal damage through apoptotic impairment and necrotic cell death.
Tiwari R, Singh RD, Khan H, Gangopadhyay S, Mittal S, Singh V, Arjaria N, Shankar J, Roy SK, Singh D, Srivastava V. Tiwari R, et al. Among authors: shankar j. Nanotoxicology. 2017 Jun;11(5):671-686. doi: 10.1080/17435390.2017.1343874. Epub 2017 Jul 4. Nanotoxicology. 2017. PMID: 28617070
There is limited information on their effect on renal system following long-term animal exposure especially at the ultramicroscopic and molecular level. ...These changes, in the long term, could lead to inhibition of the beneficial apoptotic pathway and promotion of …
There is limited information on their effect on renal system following long-term animal exposure especially at the ultramicroscopic a …
LVIS Jr 'shelf' technique: an alternative to Y stent-assisted aneurysm coiling.
Du EHY, Shankar JJS. Du EHY, et al. Among authors: shankar jjs. J Neurointerv Surg. 2016 Dec;8(12):1256-1259. doi: 10.1136/neurintsurg-2015-012246. Epub 2016 Feb 4. J Neurointerv Surg. 2016. PMID: 26847331
Our small, albeit important, case series demonstrates that the 'shelf' technique is feasible and safe with very good short-term clinical and angiographic outcomes, and may obviate the need for Y-stenting....
Our small, albeit important, case series demonstrates that the 'shelf' technique is feasible and safe with very good short-term clini …
17 results