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Regional versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN): protocol for a pragmatic, international multicentre trial.
Neuman MD, Ellenberg SS, Sieber FE, Magaziner JS, Feng R, Carson JL; REGAIN Investigators. Neuman MD, et al. BMJ Open. 2016 Nov 15;6(11):e013473. doi: 10.1136/bmjopen-2016-013473. BMJ Open. 2016. PMID: 27852723 Free PMC article. Clinical Trial.
Limited randomised evidence exists regarding potential short-term or long-term differences in outcomes between patients receiving spinal or general anaesthesia for hip fracture surgery. ...
Limited randomised evidence exists regarding potential short-term or long-term differences in outcomes between patients receiv …
Update on erythropoiesis-stimulating agents.
Goodnough LT, Shander A. Goodnough LT, et al. Among authors: shander a. Best Pract Res Clin Anaesthesiol. 2013 Mar;27(1):121-9. doi: 10.1016/j.bpa.2012.11.006. Best Pract Res Clin Anaesthesiol. 2013. PMID: 23590921 Review.
Subsequently, a number of clinical trials were undertaken in which the haemoglobin end points were targeted to be maintained at normal or high-normal ranges, in an attempt to demonstrate improvements in long-term survival. For patients undergoing spine surgery, patients wi …
Subsequently, a number of clinical trials were undertaken in which the haemoglobin end points were targeted to be maintained at normal or hi …
Economic considerations on transfusion medicine and patient blood management.
Hofmann A, Ozawa S, Farrugia A, Farmer SL, Shander A. Hofmann A, et al. Among authors: shander a. Best Pract Res Clin Anaesthesiol. 2013 Mar;27(1):59-68. doi: 10.1016/j.bpa.2013.02.001. Best Pract Res Clin Anaesthesiol. 2013. PMID: 23590916 Review.
Moreover, a large and increasing body of literature points to a dose-dependent increase of morbidity and mortality and adverse long-term outcomes associated with transfusion whereas published evidence for benefit is extremely limited. ...
Moreover, a large and increasing body of literature points to a dose-dependent increase of morbidity and mortality and adverse long-term …
The impact of blood conservation on outcomes in cardiac surgery: is it safe and effective?
Moskowitz DM, McCullough JN, Shander A, Klein JJ, Bodian CA, Goldweit RS, Ergin MA. Moskowitz DM, et al. Among authors: shander a. Ann Thorac Surg. 2010 Aug;90(2):451-8. doi: 10.1016/j.athoracsur.2010.04.089. Ann Thorac Surg. 2010. PMID: 20667328
BACKGROUND: Increasing evidence shows that perioperative blood transfusion in cardiac surgery is associated with increased postoperative morbidity and mortality and decreased long-term survival. Tolerance of "permissive anemia" is an important element of perioperative bloo …
BACKGROUND: Increasing evidence shows that perioperative blood transfusion in cardiac surgery is associated with increased postoperative mor …
Iron overload and toxicity: the hidden risk of multiple blood transfusions.
Shander A, Cappellini MD, Goodnough LT. Shander A, et al. Vox Sang. 2009 Oct;97(3):185-97. doi: 10.1111/j.1423-0410.2009.01207.x. Epub 2009 Aug 3. Vox Sang. 2009. PMID: 19663936 Review.
CONCLUSION: Increased awareness of the risks of iron overload from chronic transfusion therapy should result in greater use of interventions such as iron chelation to reduce total body iron and the risk of long-term sequelae....
CONCLUSION: Increased awareness of the risks of iron overload from chronic transfusion therapy should result in greater use of interventions …
Blood salvage use in gynecologic oncology.
Nagarsheth NP, Sharma T, Shander A, Awan A. Nagarsheth NP, et al. Among authors: shander a. Transfusion. 2009 Oct;49(10):2048-53. doi: 10.1111/j.1537-2995.2009.02256.x. Epub 2009 Jun 23. Transfusion. 2009. PMID: 19555419
Three patients that had reinfusion of cell salvage blood (all reinfusions were performed after filtration with a LRF) were studied further with emphasis placed on long-term outcomes. RESULTS: Two of the three patients did not show any evidence of metastases after surgery. …
Three patients that had reinfusion of cell salvage blood (all reinfusions were performed after filtration with a LRF) were studied further w …
Optimizing transfusion in vascular surgery: is bloodless surgery an option?
Shander A. Shander A. Vascular. 2008 Mar-Apr;16 Suppl 1:S37-47. Vascular. 2008. PMID: 18544304 Review.
However, critical situations still occur in which transfusions are necessary or unavoidable for the short-term survival of the patient. The decision-making processes for determining when to transfuse, which blood products to give, and how much are presented here with an ev …
However, critical situations still occur in which transfusions are necessary or unavoidable for the short-term survival of the patien …
Bloodless surgery in a Jehovah's Witness patient with a 12.7-kg uterine leiomyosarcoma.
Nagarsheth NP, Shander A, Malovany R, Tzeng J, Ibrahim I. Nagarsheth NP, et al. Among authors: shander a. J Surg Educ. 2007 Jul-Aug;64(4):212-9. doi: 10.1016/j.jsurg.2007.03.008. J Surg Educ. 2007. PMID: 17706574
Although her intraoperative course was significant for severe anemia with a hemoglobin of 2.5 g/dl and her postoperative course required long-term hospitalization, the patient regained full function to her preoperative performance status. ...
Although her intraoperative course was significant for severe anemia with a hemoglobin of 2.5 g/dl and her postoperative course required lon …
Anemia in the critically ill.
Shander A. Shander A. Crit Care Clin. 2004 Apr;20(2):159-78. doi: 10.1016/j.ccc.2004.01.002. Crit Care Clin. 2004. PMID: 15135458 Review.
Although the optimal hemoglobin in critically ill patients is not determined, this organ system has a generous reserve. Short-term compensated anemia is tolerated well, while exogenous erythropoietin allows patients to achieve higher hemoglobin concentrations without expos …
Although the optimal hemoglobin in critically ill patients is not determined, this organ system has a generous reserve. Short-term co …
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