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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Lacey DL, et al. Among authors: shalhoub v. Cell. 1998 Apr 17;93(2):165-76. doi: 10.1016/s0092-8674(00)81569-x. Cell. 1998. PMID: 9568710 Free article.
OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. ...
OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteocl …
Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes.
Shalhoub V, Conlon D, Tassinari M, Quinn C, Partridge N, Stein GS, Lian JB. Shalhoub V, et al. J Cell Biochem. 1992 Dec;50(4):425-40. doi: 10.1002/jcb.240500411. J Cell Biochem. 1992. PMID: 1469073
At this time, a rise in collagen and TGF beta was also observed suggesting turnover of the matrix. Short term (48 h) effects of glucocorticoid on histone H4 (reflecting cell proliferation), alkaline phosphatase, osteopontin, and osteocalcin mRNA levels reveal both up or do …
At this time, a rise in collagen and TGF beta was also observed suggesting turnover of the matrix. Short term (48 h) effects of gluco …