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Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE; GRADE Research Group. Rasouli N, et al. Diabetes Care. 2024 Apr 1;47(4):580-588. doi: 10.2337/dc23-1070. Diabetes Care. 2024. PMID: 38211595 Clinical Trial.
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity and beta-cell function. ...After adjustment for HOMA2-%S to obtain an estimate of …
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and si …
Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): Differential Treatment Effects of Dual Therapy.
Utzschneider KM, Younes N, Butera NM, Balasubramanyam A, Bergenstal RM, Barzilay J, DeSouza C, DeFronzo RA, Elasy T, Krakoff J, Kahn SE, Rasouli N, Valencia WM, Sivitz WI; GRADE Research Group. Utzschneider KM, et al. Diabetes Care. 2024 Apr 1;47(4):571-579. doi: 10.2337/dc23-1059. Diabetes Care. 2024. PMID: 38190619 Clinical Trial.
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in the sitagliptin group on initial (short-term) HbA1c response in comparison with the glimepiride and liraglutide groups....
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in …
Zinc isotopes in Late Pleistocene fossil teeth from a Southeast Asian cave setting preserve paleodietary information.
Bourgon N, Jaouen K, Bacon AM, Jochum KP, Dufour E, Duringer P, Ponche JL, Joannes-Boyau R, Boesch Q, Antoine PO, Hullot M, Weis U, Schulz-Kornas E, Trost M, Fiorillo D, Demeter F, Patole-Edoumba E, Shackelford LL, Dunn TE, Zachwieja A, Duangthongchit S, Sayavonkhamdy T, Sichanthongtip P, Sihanam D, Souksavatdy V, Hublin JJ, Tütken T. Bourgon N, et al. Among authors: shackelford ll. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4675-4681. doi: 10.1073/pnas.1911744117. Epub 2020 Feb 18. Proc Natl Acad Sci U S A. 2020. PMID: 32071235 Free PMC article.
While further work is needed to explore preservation for settings with different taphonomic conditions, the diet-related delta(66)Zn values in fossil enamel from THM cave suggest an excellent long-term preservation potential, even under tropical conditions that are well kn …
While further work is needed to explore preservation for settings with different taphonomic conditions, the diet-related delta(66)Zn values …
Dietary acid load and bone turnover during long-duration spaceflight and bed rest.
Zwart SR, Rice BL, Dlouhy H, Shackelford LC, Heer M, Koslovsky MD, Smith SM. Zwart SR, et al. Among authors: shackelford lc. Am J Clin Nutr. 2018 May 1;107(5):834-844. doi: 10.1093/ajcn/nqy029. Am J Clin Nutr. 2018. PMID: 29722847 Free PMC article. Clinical Trial.
The results were compared with data from a 70-d bed rest study, in which control (but not exercising) subjects' APro:K was associated with higher NTX during bed rest. CONCLUSIONS: Long-term lowering of NEAP by increasing vegetable and fruit intake may protect against chang …
The results were compared with data from a 70-d bed rest study, in which control (but not exercising) subjects' APro:K was associated with h …
Bone metabolism and renal stone risk during International Space Station missions.
Smith SM, Heer M, Shackelford LC, Sibonga JD, Spatz J, Pietrzyk RA, Hudson EK, Zwart SR. Smith SM, et al. Among authors: shackelford lc. Bone. 2015 Dec;81:712-720. doi: 10.1016/j.bone.2015.10.002. Epub 2015 Oct 8. Bone. 2015. PMID: 26456109
Loss of bone calcium leads to concerns about fracture risk and increased long-term risk of osteoporosis. Bone metabolism involves many factors and is interconnected with muscle metabolism and diet. ...
Loss of bone calcium leads to concerns about fracture risk and increased long-term risk of osteoporosis. Bone metabolism involves man …
Natural calcium isotopic composition of urine as a marker of bone mineral balance.
Skulan J, Bullen T, Anbar AD, Puzas JE, Shackelford L, LeBlanc A, Smith SM. Skulan J, et al. Among authors: shackelford l. Clin Chem. 2007 Jun;53(6):1155-8. doi: 10.1373/clinchem.2006.080143. Epub 2007 Apr 26. Clin Chem. 2007. PMID: 17463176
If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that cannot be detected with other techniques. ...
If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that c …
Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the mir space station.
Smith SM, Wastney ME, O'Brien KO, Morukov BV, Larina IM, Abrams SA, Davis-Street JE, Oganov V, Shackelford LC. Smith SM, et al. Among authors: shackelford lc. J Bone Miner Res. 2005 Feb;20(2):208-18. doi: 10.1359/JBMR.041105. Epub 2004 Nov 8. J Bone Miner Res. 2005. PMID: 15647814 Free article.
Bone loss is a current limitation for long-term space exploration. Bone markers, calcitropic hormones, and calcium kinetics of crew members on space missions of 4-6 months were evaluated. ...
Bone loss is a current limitation for long-term space exploration. Bone markers, calcitropic hormones, and calcium kinetics of crew m …
Hologic QDR 2000 whole-body scans: a comparison of three combinations of scan modes and analysis software.
Spector E, LeBlanc A, Shackelford L. Spector E, et al. Among authors: shackelford l. Osteoporos Int. 1995;5(6):440-5. doi: 10.1007/BF01626605. Osteoporos Int. 1995. PMID: 8695965
This study reports on the short-term in vivo precision and absolute measurements of three combinations of whole-body scan modes and analysis software using a Hologic QDR 2000 dual-energy X-ray densitometer. ...In general, there was no significant difference among the three …
This study reports on the short-term in vivo precision and absolute measurements of three combinations of whole-body scan modes and a …