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β-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition.
Orr AL, Hanson JE, Li D, Klotz A, Wright S, Schenk D, Seubert P, Madison DV. Orr AL, et al. Among authors: seubert p. Neuron. 2014 Jun 18;82(6):1334-45. doi: 10.1016/j.neuron.2014.04.039. Neuron. 2014. PMID: 24945775 Free PMC article.
It has been widely reported that beta-amyloid peptide (Abeta) blocks long-term potentiation (LTP) of hippocampal synapses. Here, we show evidence that Abeta more potently blocks the potentiation of excitatory postsynaptic potential (EPSP)-spike coupling (E-S potentiation). …
It has been widely reported that beta-amyloid peptide (Abeta) blocks long-term potentiation (LTP) of hippocampal synapses. Here, we s …
Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.
Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Welzel AT, et al. Among authors: seubert p. Biochemistry. 2014 Jun 24;53(24):3908-21. doi: 10.1021/bi5003053. Biochemistry. 2014. PMID: 24840308 Free PMC article.
Mass spectrometry confirmed its identity as a noncovalently bonded Abeta40 homodimer that impaired hippocampal long-term potentiation (LTP) in vivo. We further report the detection of Abeta-containing fragments of APP in the 7PA2 medium that extend N-terminal from Asp1 of …
Mass spectrometry confirmed its identity as a noncovalently bonded Abeta40 homodimer that impaired hippocampal long-term potentiation …
Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice.
Larson J, Lynch G, Games D, Seubert P. Larson J, et al. Among authors: seubert p. Brain Res. 1999 Sep 4;840(1-2):23-35. doi: 10.1016/s0006-8993(99)01698-4. Brain Res. 1999. PMID: 10517949
The transgenic mice at 4-5 months of age, prior to the formation of amyloid-beta peptide deposits in these animals, differed from non-transgenic control mice in three respects: (1) paired-pulse facilitation (PPF) was enhanced; (2) responses to high frequency stimulation bursts we …
The transgenic mice at 4-5 months of age, prior to the formation of amyloid-beta peptide deposits in these animals, differed from non-transg …
Long-term potentiation: persisting problems and recent results.
Lynch G, Muller D, Seubert P, Larson J. Lynch G, et al. Among authors: seubert p. Brain Res Bull. 1988 Sep;21(3):363-72. doi: 10.1016/0361-9230(88)90148-7. Brain Res Bull. 1988. PMID: 2850841 Review.
In this paper we discuss recent experimental results pertinent to three unresolved issues regarding the long-term potentiation (LTP) effect: the nature of its enduring substrates, the biochemical mechanisms that produce it, and its potential role in memory. ...
In this paper we discuss recent experimental results pertinent to three unresolved issues regarding the long-term potentiation (LTP) …