Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex.
Astrinidis A, Li C, Zhang EY, Zhao X, Zhao S, Guo M, Olatoke T, Mattam U, Huang R, Zhang AG, Pitstick L, Kopras EJ, Gupta N, Jandarov R, Smith EP, Fugate E, Lindquist D, Markiewski MM, Karbowniczek M, Wikenheiser-Brokamp KA, Setchell KDR, McCormack FX, Xu Y, Yu JJ.
Astrinidis A, et al. Among authors: setchell kdr.
JCI Insight. 2023 May 8;8(9):e166850. doi: 10.1172/jci.insight.166850.
JCI Insight. 2023.
PMID: 36927688
Free PMC article.
In vivo, 17a significantly decreased the growth of TSC2-null cell-derived mouse xenografts and short-term lung colonization by TSC2-null cells. Combined rapamycin and 17a treatment synergistically inhibited renal cystadenoma growth in Tsc2+/- mice, consistent with increase …
In vivo, 17a significantly decreased the growth of TSC2-null cell-derived mouse xenografts and short-term lung colonization by TSC2-n …