SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.
Lee B, An HJ, Kim DH, Lee MK, Jeong HH, Chung KW, Go Y, Seo AY, Kim IY, Seong JK, Yu BP, Lee J, Im E, Lee IK, Lee MS, Yamada KI, Chung HY.
Lee B, et al. Among authors: seo ay.
Exp Mol Med. 2022 Nov;54(11):2036-2046. doi: 10.1038/s12276-022-00888-9. Epub 2022 Nov 25.
Exp Mol Med. 2022.
PMID: 36434042
Free PMC article.
SMP30-KO mice gained more weight than WT mice without a change in food intake in response to short-term high-fat diet feeding. Indirect calorimetry and cold-challenge experiments indicated that energy expenditure is lower in SMP30-KO mice, which is associated with decrease …
SMP30-KO mice gained more weight than WT mice without a change in food intake in response to short-term high-fat diet feeding. Indire …