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SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.
Lee B, An HJ, Kim DH, Lee MK, Jeong HH, Chung KW, Go Y, Seo AY, Kim IY, Seong JK, Yu BP, Lee J, Im E, Lee IK, Lee MS, Yamada KI, Chung HY. Lee B, et al. Among authors: seo ay. Exp Mol Med. 2022 Nov;54(11):2036-2046. doi: 10.1038/s12276-022-00888-9. Epub 2022 Nov 25. Exp Mol Med. 2022. PMID: 36434042 Free PMC article.
SMP30-KO mice gained more weight than WT mice without a change in food intake in response to short-term high-fat diet feeding. Indirect calorimetry and cold-challenge experiments indicated that energy expenditure is lower in SMP30-KO mice, which is associated with decrease …
SMP30-KO mice gained more weight than WT mice without a change in food intake in response to short-term high-fat diet feeding. Indire …
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept.
Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, Seo AY, Chung JH, Jung YS, Im E, Lee J, Kim ND, Choi YJ, Im DS, Yu BP. Chung HY, et al. Among authors: seo ay. Aging Dis. 2019 Apr 1;10(2):367-382. doi: 10.14336/AD.2018.0324. eCollection 2019 Apr. Aging Dis. 2019. PMID: 31011483 Free PMC article. Review.
The later sections of this review present our expanded view of age-related senescent inflammation, a process we term "senoinflammation", that we propose here as a novel concept. ...
The later sections of this review present our expanded view of age-related senescent inflammation, a process we term "senoinflammatio …
AMPK and vacuole-associated Atg14p orchestrate mu-lipophagy for energy production and long-term survival under glucose starvation.
Seo AY, Lau PW, Feliciano D, Sengupta P, Gros MAL, Cinquin B, Larabell CA, Lippincott-Schwartz J. Seo AY, et al. Elife. 2017 Apr 10;6:e21690. doi: 10.7554/eLife.21690. Elife. 2017. PMID: 28394250 Free PMC article.
Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-drop …
Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability a …
Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae.
Aris JP, Fishwick LK, Marraffini ML, Seo AY, Leeuwenburgh C, Dunn WA Jr. Aris JP, et al. Among authors: seo ay. Subcell Biochem. 2012;57:161-86. doi: 10.1007/978-94-007-2561-4_8. Subcell Biochem. 2012. PMID: 22094422 Free PMC article. Review.
Understanding how non-dividing cells remain viable over long periods of time, which may be decades in humans, is of central importance in understanding mechanisms of aging and longevity. The long-term viability of non-dividing cells, known as chronological longevity, relie …
Understanding how non-dividing cells remain viable over long periods of time, which may be decades in humans, is of central importance in un …
Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise.
Seo AY, Hofer T, Sung B, Judge S, Chung HY, Leeuwenburgh C. Seo AY, et al. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):529-38. doi: 10.1089/ars.2006.8.529. Antioxid Redox Signal. 2006. PMID: 16677097
The authors investigated whether mild calorie restriction and long-term voluntary exercise could attenuate these changes. Four groups of male Fischer 344 rats were compared: young (6 mo), old (24 mo), old calorie restricted (8% CR, 24 mo) and old CR with daily voluntary wh …
The authors investigated whether mild calorie restriction and long-term voluntary exercise could attenuate these changes. Four groups …