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Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: National Heart, Lung, and Blood Institute Workshop Report.
Palakshappa JA, Batt JAE, Bodine SC, Connolly BA, Doles J, Falvey JR, Ferrante LE, Files DC, Harhay MO, Harrell K, Hippensteel JA, Iwashyna TJ, Jackson JC, Lane-Fall MB, Monje M, Moss M, Needham DM, Semler MW, Lahiri S, Larsson L, Sevin CM, Sharshar T, Singer B, Stevens T, Taylor SP, Gomez CR, Zhou G, Girard TD, Hough CL. Palakshappa JA, et al. Among authors: semler mw. Am J Respir Crit Care Med. 2024 Mar 13. doi: 10.1164/rccm.202311-2130WS. Online ahead of print. Am J Respir Crit Care Med. 2024. PMID: 38477657
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. ...
Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly i …
Oxygen-Saturation Targets and Cognitive and Functional Outcomes in Mechanically Ventilated Adults.
Mart MF, Semler MW, Jenkins CA, Wang G, Casey JD, Ely EW, Jackson JC, Kiehl AL, Bryant PT, Pugh SK, Wang L, DeMasi S, Rice TW, Bernard GR, Freundlich RE, Self WH, Han JH. Mart MF, et al. Among authors: semler mw. Am J Respir Crit Care Med. 2024 Apr 1;209(7):861-870. doi: 10.1164/rccm.202310-1826OC. Am J Respir Crit Care Med. 2024. PMID: 38285550
Rationale: Among mechanically ventilated critically ill adults, the PILOT (Pragmatic Investigation of Optimal Oxygen Targets) trial demonstrated no difference in ventilator-free days among lower, intermediate, and higher oxygen-saturation targets. The effects on long-term …
Rationale: Among mechanically ventilated critically ill adults, the PILOT (Pragmatic Investigation of Optimal Oxygen Targets) trial demonstr …
Modifiable in-hospital factors for 12-month global cognition, post-traumatic stress disorder symptoms, and depression symptoms in adults hospitalized with COVID-19.
Han JH, Jackson JC, Orun OM, Brown SM, Casey JD, Clark L, Collins SP, Cordero K, Ginde AA, Gong MN, Hough CL, Iwashyna TJ, Kiehl AL, Lauck A, Leither LM, Lindsell CJ, Patel MB, Raman R, Rice TW, Ringwood NJ, Sheppard KL, Semler MW, Thompson BT, Ely EW, Self WH; National Heart, Lung, and Blood Institute PETAL Clinical Trials Network. Han JH, et al. Among authors: semler mw. Influenza Other Respir Viruses. 2023 Sep;17(9):e13197. doi: 10.1111/irv.13197. Influenza Other Respir Viruses. 2023. PMID: 37752063 Free PMC article.
CONCLUSION: Potentially modifiable factors associated with better long-term outcomes included remdesivir use (associated with better cognitive function), avoidance of delirium (associated with less PTSD and depression symptoms), and increased virtual interactions with frie …
CONCLUSION: Potentially modifiable factors associated with better long-term outcomes included remdesivir use (associated with better …
Laryngoscopy and Tracheal Intubation: Does Use of a Video Laryngoscope Facilitate Both Steps of the Procedure?
Prekker ME, Trent SA, Lofrano A, Russell DW, Barnes CR, Brewer JM, Doerschug KC, Gaillard JP, Gandotra S, Ginde AA, Ghamande S, Gibbs KW, Hughes CG, Janz DR, Khan A, Mitchell SH, Page DB, Rice TW, Self WH, Smith LM, Stempek SB, Vonderhaar DJ, West JR, Whitson MR, Casey JD, Semler MW, Driver BE. Prekker ME, et al. Among authors: semler mw. Ann Emerg Med. 2023 Oct;82(4):425-431. doi: 10.1016/j.annemergmed.2023.02.016. Epub 2023 Apr 5. Ann Emerg Med. 2023. PMID: 37028995
Video laryngoscope use modified the association between grade of view and successful intubation on the first attempt such that intubation on the first attempt was similar between video laryngoscope and direct laryngoscope at a grade 1 view and higher for video laryngoscope than d …
Video laryngoscope use modified the association between grade of view and successful intubation on the first attempt such that intubation on …
Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial.
Williams Roberson S, Nwosu S, Collar EM, Kiehl AL, Harrison FE, Bastarache J, Wilson JE, Mart MF, Sevransky JE, Ely EW, Lindsell CJ, Jackson JC; VICTAS Investigators. Williams Roberson S, et al. JAMA Netw Open. 2023 Feb 1;6(2):e230380. doi: 10.1001/jamanetworkopen.2023.0380. JAMA Netw Open. 2023. PMID: 36853612 Free PMC article. Clinical Trial.
IMPORTANCE: Sepsis is associated with long-term cognitive impairment and worse psychological and functional outcomes. ...These findings challenge the hypothesis that antioxidant and anti-inflammatory therapy during critical illness mitigates the development of long-term …
IMPORTANCE: Sepsis is associated with long-term cognitive impairment and worse psychological and functional outcomes. ...These findin …
Cognitive Outcomes in the Pragmatic Investigation of optimaL Oxygen Targets (CO-PILOT) trial: protocol and statistical analysis plan.
Mart MF, Semler MW, Bernard G, Casey JD, Ely EW, Freundlich R, Jackson JC, Kiehl A, Jenkins C, Wang G, Lindsell C, Bryant P, Rice TW, Self WH, Stollings J, Wanderer JP, Wang L, Han JH. Mart MF, et al. Among authors: semler mw. BMJ Open. 2022 Nov 1;12(11):e064517. doi: 10.1136/bmjopen-2022-064517. BMJ Open. 2022. PMID: 36319061 Free PMC article.
INTRODUCTION: Long-term cognitive impairment is one of the most common complications of critical illness among survivors who receive mechanical ventilation. ...Different oxygen targets during mechanical ventilation have the potential to alter long-term cognitive fun …
INTRODUCTION: Long-term cognitive impairment is one of the most common complications of critical illness among survivors who receive …
Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.
Sunderraj A, Cho C, Cai X, Gupta S, Mehta R, Isakova T, Leaf DE, Srivastava A; STOP-COVID Investigators. Sunderraj A, et al. Crit Care Explor. 2022 Aug 29;4(9):e0755. doi: 10.1097/CCE.0000000000000755. eCollection 2022 Sep. Crit Care Explor. 2022. PMID: 36050992 Free PMC article.
Effect modification by the number of risk factors was assessed through a multiplicative interaction term in the logistic regression model. Among the 5,037 patients included (mean age, 60.9 yr [ 14.7], 3,179 [63.1%] male), 1,786 (35.4%) died within 28 days. ...
Effect modification by the number of risk factors was assessed through a multiplicative interaction term in the logistic regression m …
Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults.
Han JH, Ginde AA, Brown SM, Baughman A, Collar EM, Ely EW, Gong MN, Hope AA, Hou PC, Hough CL, Iwashyna TJ, Jackson JC, Khan A, Orun OM, Patel MB, Raman R, Rice TW, Ringwood N, Semler MW, Shapiro NI, Talmor DS, Self WH; Vitamin D to Improve Outcomes by Leveraging Early Treatment Network Investigators. Han JH, et al. Among authors: semler mw. Chest. 2021 Sep;160(3):909-918. doi: 10.1016/j.chest.2021.03.046. Epub 2021 Apr 2. Chest. 2021. PMID: 33819472 Free PMC article. Clinical Trial.
BACKGROUND: Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. RESEARCH QUESTION: Does a single high-dose (540,000 International Units) enteral treatment of vitamin D3 given shortly after …
BACKGROUND: Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term …
Effect of Early Balanced Crystalloids Before ICU Admission on Sepsis Outcomes.
Jackson KE, Wang L, Casey JD, Bernard GR, Self WH, Rice TW, Semler MW; SMART Investigators and the Pragmatic Critical Care Research Group. Jackson KE, et al. Among authors: semler mw. Chest. 2021 Feb;159(2):585-595. doi: 10.1016/j.chest.2020.08.2068. Epub 2020 Aug 31. Chest. 2021. PMID: 32882244 Free PMC article. Clinical Trial.
We performed logistic regression modeling for 30-day in-hospital mortality with an interaction term between randomized group (balanced crystalloids vs saline) and study period (ICU-only period vs ED and ICU period). ...
We performed logistic regression modeling for 30-day in-hospital mortality with an interaction term between randomized group (balance …
Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.
Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. Semler MW, et al. Am J Respir Crit Care Med. 2020 Aug 15;202(4):511-523. doi: 10.1164/rccm.201908-1595WS. Am J Respir Crit Care Med. 2020. PMID: 32150460 Free PMC article.
This working group identified recommendations for future research, including 1) focusing on understanding the clinical, physiological, and biological underpinnings of heterogeneity in syndromes, diseases, and treatment response with the goal of developing targeted, personalized i …
This working group identified recommendations for future research, including 1) focusing on understanding the clinical, physiological, and b …
11 results