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Tailored approach to study Legionella infection using a lattice light sheet microscope (LLSM).
Yi X, Miao H, Lo JK, Elsheikh MM, Lee TH, Jiang C, Zhang Y, Segelke BW, Overton KW, Bremer PT, Laurence TA. Yi X, et al. Among authors: segelke bw. Biomed Opt Express. 2022 Jul 7;13(8):4134-4159. doi: 10.1364/BOE.459012. eCollection 2022 Aug 1. Biomed Opt Express. 2022. PMID: 36032581 Free PMC article.
Our work demonstrates the benefits of using LLSM for studying long-term questions in bacterial infection. Our free-for-use modifications and workflow designs on the use of LLSM system contributes to the adoption and promotion of the state-of-the-art LLSM technology for bot …
Our work demonstrates the benefits of using LLSM for studying long-term questions in bacterial infection. Our free-for-use modificati …
A fixed-target platform for serial femtosecond crystallography in a hydrated environment.
Shelby ML, Gilbile D, Grant TD, Seuring C, Segelke BW, He W, Evans AC, Pakendorf T, Fischer P, Hunter MS, Batyuk A, Barthelmess M, Meents A, Coleman MA, Kuhl TL, Frank M. Shelby ML, et al. Among authors: segelke bw. IUCrJ. 2020 Jan 1;7(Pt 1):30-41. doi: 10.1107/S2052252519014003. eCollection 2020 Jan 1. IUCrJ. 2020. PMID: 31949902 Free PMC article.
The encapsulated sample is delivered into the X-ray beam on fixed targets for rapid scanning using the Roadrunner fixed-target system towards a long-term goal of low-background measurements on weakly diffracting samples. ...
The encapsulated sample is delivered into the X-ray beam on fixed targets for rapid scanning using the Roadrunner fixed-target system toward …
Structure and function of REP34 implicates carboxypeptidase activity in Francisella tularensis host cell invasion.
Feld GK, El-Etr S, Corzett MH, Hunter MS, Belhocine K, Monack DM, Frank M, Segelke BW, Rasley A. Feld GK, et al. Among authors: segelke bw. J Biol Chem. 2014 Oct 31;289(44):30668-30679. doi: 10.1074/jbc.M114.599381. Epub 2014 Sep 17. J Biol Chem. 2014. PMID: 25231992 Free PMC article.
Previously, we identified seven F. tularensis proteins that induce a rapid encystment phenotype (REP) in the free-living amoeba, Acanthamoeba castellanii. Encystment is essential to the pathogen's long term intracellular survival in the amoeba. Here, we characterize the ce …
Previously, we identified seven F. tularensis proteins that induce a rapid encystment phenotype (REP) in the free-living amoeba, Acanthamoeb …
Practical applications of structural genomics technologies for mutagen research.
Zemla A, Segelke BW. Zemla A, et al. Among authors: segelke bw. Mutat Res. 2011 Jun 17;722(2):165-70. doi: 10.1016/j.mrgentox.2010.12.006. Epub 2010 Dec 21. Mutat Res. 2011. PMID: 21182983
Here we present a perspective on a range of practical uses of structural genomics for mutagen research. Structural genomics is an overloaded term and requires some definition to bound the discussion; we give a brief description of public and private structural genomics end …
Here we present a perspective on a range of practical uses of structural genomics for mutagen research. Structural genomics is an overloaded …