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Following the Status of Visual Cortex Over Time in Patients With Macular Degeneration Reveals Atrophy of Visually Deprived Brain Regions.
Hanson RLW, Gale RP, Gouws AD, Airody A, Scott MTW, Akthar F, Waterson S, Wells MT, Wright AJ, Bell K, Silson E, Baseler HA, Morland AB. Hanson RLW, et al. Among authors: scott mtw. Invest Ophthalmol Vis Sci. 2019 Dec 2;60(15):5045-5051. doi: 10.1167/iovs.18-25823. Invest Ophthalmol Vis Sci. 2019. PMID: 31800962 Free article.
Whole brain, T1-weighted magnetic resonance imaging was taken at diagnosis (before antiangiogenic treatment to stabilize the retina), during the 3- to 4-month initial treatment period, with a long-term follow-up approximately 5 (range 3.8-6.1 years) years later. RESULTS: S …
Whole brain, T1-weighted magnetic resonance imaging was taken at diagnosis (before antiangiogenic treatment to stabilize the retina), during …
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors.
Baquero P, Dawson A, Mukhopadhyay A, Kuntz EM, Mitchell R, Olivares O, Ianniciello A, Scott MT, Dunn K, Nicastri MC, Winkler JD, Michie AM, Ryan KM, Halsey C, Gottlieb E, Keaney EP, Murphy LO, Amaravadi RK, Holyoake TL, Helgason GV. Baquero P, et al. Among authors: scott mt. Leukemia. 2019 Apr;33(4):981-994. doi: 10.1038/s41375-018-0252-4. Epub 2018 Sep 5. Leukemia. 2019. PMID: 30185934 Free PMC article.
In parallel, we use cell division tracing, phenotyping of primary CML cells, and a robust xenotransplantation model of human CML, to investigate the effect of Lys05, a highly potent lysosomotropic agent, and PIK-III, a selective inhibitor of VPS34, on the survival and function of …
In parallel, we use cell division tracing, phenotyping of primary CML cells, and a robust xenotransplantation model of human CML, to investi …
hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.
Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL. Pellicano F, et al. Among authors: scott mt. Blood. 2018 Apr 5;131(14):1532-1544. doi: 10.1182/blood-2017-05-783845. Epub 2018 Feb 5. Blood. 2018. PMID: 29437554 Free PMC article.
Understanding the mechanisms by which leukemic SPCs maintain quiescence will help to clarify how they persist during long-term targeted treatment. We have identified a novel BCR-ABL1 protein kinase-dependent pathway mediated by the upregulation of hsa-mir183, the downregul …
Understanding the mechanisms by which leukemic SPCs maintain quiescence will help to clarify how they persist during long-term target …
Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition.
Scott MT, Korfi K, Saffrey P, Hopcroft LE, Kinstrie R, Pellicano F, Guenther C, Gallipoli P, Cruz M, Dunn K, Jorgensen HG, Cassels JE, Hamilton A, Crossan A, Sinclair A, Holyoake TL, Vetrie D. Scott MT, et al. Cancer Discov. 2016 Nov;6(11):1248-1257. doi: 10.1158/2159-8290.CD-16-0263. Epub 2016 Sep 14. Cancer Discov. 2016. PMID: 27630125 Free PMC article.
Strikingly, treatment of primary CML cells with either EZH2i or TKI alone caused significant upregulation of H3K27me3 targets, and combined treatment further potentiated these effects and resulted in significant loss of LSCs compared to TKI alone, in vitro, and in long-term …
Strikingly, treatment of primary CML cells with either EZH2i or TKI alone caused significant upregulation of H3K27me3 targets, and combined …
Fear potentiated startle increases phospholipase D (PLD) expression/activity and PLD-linked metabotropic glutamate receptor mediated post-tetanic potentiation in rat amygdala.
Krishnan B, Scott MT, Pollandt S, Schroeder B, Kurosky A, Shinnick-Gallagher P. Krishnan B, et al. Among authors: scott mt. Neurobiol Learn Mem. 2016 Feb;128:65-79. doi: 10.1016/j.nlm.2015.12.009. Epub 2015 Dec 31. Neurobiol Learn Mem. 2016. PMID: 26748024 Free PMC article.
Long-term memory (LTM) of fear stores activity dependent modifications that include changes in amygdala signaling. ...FPS Post-tetanic potentiation (PTP) immediately following long-term potentiation (LTP) induction was significantly increased. Blocking PLD-mGluR sig …
Long-term memory (LTM) of fear stores activity dependent modifications that include changes in amygdala signaling. ...FPS Post-tetani …
Radiation therapy for hemangioendothelioma: the university of Florida experience.
Scott MT, Indelicato DJ, Morris CG, Gibbs CP Jr, Scarborough MT, Reith JD, Marcus RB Jr, Zlotecki R, Mendenhall WM. Scott MT, et al. Am J Clin Oncol. 2014 Aug;37(4):360-3. doi: 10.1097/COC.0b013e31827a7cde. Am J Clin Oncol. 2014. PMID: 23275275
OBJECTIVES: The benefit of radiotherapy (RT) for unresectable hemangioendotheliomas or patients with a high risk of local recurrence is unclear. This single-institution report describes the long-term effectiveness of RT for hemangioendothelioma. METHODS: From 1976 to 2009, …
OBJECTIVES: The benefit of radiotherapy (RT) for unresectable hemangioendotheliomas or patients with a high risk of local recurrence is uncl …