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Efficacy, safety and tolerability of rozanolixizumab in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a randomised, subject-blind, investigator-blind, placebo-controlled, phase 2a trial and open-label extension study.
Querol L, De Sèze J, Dysgaard T, Levine T, Rao TH, Rivner M, Hartung HP, Kiessling P, Shimizu S, Marmol D, Bozorg A, Colson AO, Massow U, Eftimov F; CIDP01 Study Investigators. Querol L, et al. J Neurol Neurosurg Psychiatry. 2024 May 10:jnnp-2023-333112. doi: 10.1136/jnnp-2023-333112. Online ahead of print. J Neurol Neurosurg Psychiatry. 2024. PMID: 38729747 Free article.
CONCLUSIONS: Rozanolixizumab did not show efficacy in patients with CIDP in this study, although this could be due to a relatively high placebo stability rate. Rozanolixizumab was well tolerated over medium-to-long-term weekly use, with an acceptable safety profile....
CONCLUSIONS: Rozanolixizumab did not show efficacy in patients with CIDP in this study, although this could be due to a relatively high plac …
Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque.
Schmidt JK, Wilson RL, Davenport BN, Hacker TA, Fitz C, Simmons HA, Schotzko ML, Golos TG, Jones HN. Schmidt JK, et al. bioRxiv [Preprint]. 2024 Apr 14:2024.04.10.588902. doi: 10.1101/2024.04.10.588902. bioRxiv. 2024. PMID: 38645086 Free PMC article. Preprint.
The uterine artery catheterization approach enabled successful delivery of nanoparticles to maternal circulation in close proximity to the placenta with no concerns to maternal or fetal health in this short-term feasibility study. In the future, this delivery approach can …
The uterine artery catheterization approach enabled successful delivery of nanoparticles to maternal circulation in close proximity to the p …
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight.
Garcia-Medina JS, Sienkiewicz K, Narayanan SA, Overbey EG, Grigorev K, Ryon KA, Burke M, Proszynski J, Tierney B, Schmidt CM, Mencia-Trinchant N, Klotz R, Ortiz V, Foox J, Chin C, Najjar D, Matei I, Chan I, Cruchaga C, Kleinman A, Kim J, Lucaci A, Loy C, Mzava O, De Vlaminck I, Singaraju A, Taylor LE, Schmidt JC, Schmidt MA, Blease K, Moreno J, Boddicker A, Zhao J, Lajoie B, Altomare A, Kruglyak S, Levy S, Yu M, Hassane DC, Bailey SM, Bolton K, Mateus J, Mason CE. Garcia-Medina JS, et al. Among authors: schmidt jc. Precis Clin Med. 2024 Apr 8;7(1):pbae007. doi: 10.1093/pcmedi/pbae007. eCollection 2024 Mar. Precis Clin Med. 2024. PMID: 38634106 Free PMC article.
No significant clonal hematopoiesis of indeterminate potential (CHIP) or whole-genome instability was observed. The long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months post-flight. ...
No significant clonal hematopoiesis of indeterminate potential (CHIP) or whole-genome instability was observed. The long-term gene ex …
Impact of 24 h shifts on urinary catecholamine in emergency physicians: a cross-over randomized trial.
Dutheil F, Fournier A, Perrier C, Richard D, Trousselard M, Mnatzaganian G, Baker JS, Bagheri R, Mermillod M, Clinchamps M, Schmidt J, Bouillon-Minois JB. Dutheil F, et al. Among authors: schmidt j. Sci Rep. 2024 Mar 27;14(1):7329. doi: 10.1038/s41598-024-58070-2. Sci Rep. 2024. PMID: 38538760 Free PMC article. Clinical Trial.
Catecholamines are supposed to be chronic stress biomarker. However, no study has used catecholamines to assess short-term residual stress or measured them over multiple shifts. A shift-randomized trial was conducted to study urinary catecholamines levels of 17 emergency p …
Catecholamines are supposed to be chronic stress biomarker. However, no study has used catecholamines to assess short-term residual s …
[Transcranial direct current stimulation to enhance training effectiveness in chronic poststroke aphasia-A challenge for recruiting participants].
Unger N, Stahl B, Darkow R, Scholz V, Weinmar I, Schmidt J, Breitenstein C, Meinzer M, Grewe T, Flöel A. Unger N, et al. Among authors: schmidt j. Nervenarzt. 2024 Apr;95(4):368-375. doi: 10.1007/s00115-023-01572-7. Epub 2024 Jan 4. Nervenarzt. 2024. PMID: 38175228 Free PMC article. Review. German.
PROVISIONAL RESULTS: Up until now, 110 patients have been included into the study. The largest short-term response was achieved via television and radio. The largest long-term response was obtained through recruitment via logopaedic and neurological facilities, pati …
PROVISIONAL RESULTS: Up until now, 110 patients have been included into the study. The largest short-term response was achieved via t …
Herpes Simplex Virus Hepatitis in Patients Requiring Intensive Care Unit Admission: A Retrospective, Multicenter, Observational Study.
Frapard T, Amaddeo G, Decavele M, Abback PS, Gaillet A, Bouzbib C, Vanlemmens C, Younan R, Canet E, Moreau AS, Neuville M, Azoulay E, Sitbon A, Mokart D, Radenne S, Abergel A, Guichon C, Roux O, Bonadona A, Mekontso Dessap A, De Jong A, Dumortier J, de Prost N; GrrrOH and Gref2 study groups. Frapard T, et al. Open Forum Infect Dis. 2023 Oct 3;10(11):ofad484. doi: 10.1093/ofid/ofad484. eCollection 2023 Nov. Open Forum Infect Dis. 2023. PMID: 37942463 Free PMC article.
The clinical features and short-term prognosis of patients admitted to the intensive care unit for herpes hepatitis are lacking. ...
The clinical features and short-term prognosis of patients admitted to the intensive care unit for herpes hepatitis are lacking. ...
Is nitrification inhibition the bottleneck of integrating hydrothermal liquefaction in wastewater treatment plants?
Macêdo WV, Schmidt JS, Jensen SB, Biller P, Vergeynst L. Macêdo WV, et al. Among authors: schmidt js. J Environ Manage. 2023 Dec 15;348:119046. doi: 10.1016/j.jenvman.2023.119046. Epub 2023 Oct 11. J Environ Manage. 2023. PMID: 37832286 Free article.
Potential nitrification inhibition is concerning, and further long-term studies are needed to fully investigate the impacts....
Potential nitrification inhibition is concerning, and further long-term studies are needed to fully investigate the impacts....
Which severe COVID-19 patients could benefit from high dose dexamethasone? A Bayesian post-hoc reanalysis of the COVIDICUS randomized clinical trial.
Chevret S, Bouadma L, Dupuis C, Burdet C, Timsit JF; COVIDICUS RCT group. Chevret S, et al. Ann Intensive Care. 2023 Aug 27;13(1):75. doi: 10.1186/s13613-023-01168-z. Ann Intensive Care. 2023. PMID: 37634234 Free PMC article.
TRIAL REGISTRATION: NCT04344730, date of registration April 14, 2020 ( https://clinicaltrials.gov/ct2/show/NCT04344730?term=NCT04344730&draw=2&rank=1 ); EudraCT: 2020-001457-43 ( https://www.clinicaltrialsregister.eu/ctr-search/search?...
TRIAL REGISTRATION: NCT04344730, date of registration April 14, 2020 ( https://clinicaltrials.gov/ct2/show/NCT04344730?term=NCT043447 …
Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus macaque (Macaca mulatta) model.
Koenig MR, Mitzey AM, Zeng X, Reyes L, Simmons HA, Morgan TK, Bohm EK, Pritchard JC, Schmidt JA, Ren E, Leyva Jaimes FB, Winston E, Basu P, Weiler AM, Friedrich TC, Aliota MT, Mohr EL, Golos TG. Koenig MR, et al. Among authors: schmidt ja. PLoS Pathog. 2023 Aug 7;19(8):e1011274. doi: 10.1371/journal.ppat.1011274. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37549143 Free PMC article.
Zika virus (ZIKV) can be transmitted vertically from mother to fetus during pregnancy, resulting in a range of outcomes including severe birth defects and fetal/infant death. Potential pathways of vertical transmission in utero have been proposed but remain undefined. ...T …
Zika virus (ZIKV) can be transmitted vertically from mother to fetus during pregnancy, resulting in a range of outcomes including severe …
342 results