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Inhibition of p90 ribosomal S6 kinases disrupts melanoma cell growth and immune evasion.
Kosnopfel C, Wendlinger S, Niessner H, Siewert J, Sinnberg T, Hofmann A, Wohlfarth J, Schrama D, Berthold M, Siedel C, Sauer B, Jayanthan A, Lenz G, Dunn SE, Schilling B, Schittek B. Kosnopfel C, et al. Among authors: schilling b. J Exp Clin Cancer Res. 2023 Jul 19;42(1):175. doi: 10.1186/s13046-023-02755-5. J Exp Clin Cancer Res. 2023. PMID: 37464364 Free PMC article.
METHODS: RSK activity and the functional effects of its inhibition by specific small molecule inhibitors were investigated in established melanoma cell lines and patient-derived short-term cultures from different MAPK pathway-hyperactivated genomic subgroups (NRAS(Mut), BR …
METHODS: RSK activity and the functional effects of its inhibition by specific small molecule inhibitors were investigated in established me …
Author Correction: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.
Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, Graf GH, Kraus VB, Kraus WE, Lin DTS, Pieper CF, Ramaker ME, Bhapkar M, Das SK, Ferrucci L, Hastings WJ, Kebbe M, Parker DC, Racette SB, Shalev I, Schilling B, Belsky DW. Waziry R, et al. Among authors: schilling b. Nat Aging. 2023 Jun;3(6):753. doi: 10.1038/s43587-023-00432-y. Nat Aging. 2023. PMID: 37161091 Free PMC article. No abstract available.
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.
Waziry R, Ryan CP, Corcoran DL, Huffman KM, Kobor MS, Kothari M, Graf GH, Kraus VB, Kraus WE, Lin DTS, Pieper CF, Ramaker ME, Bhapkar M, Das SK, Ferrucci L, Hastings WJ, Kebbe M, Parker DC, Racette SB, Shalev I, Schilling B, Belsky DW. Waziry R, et al. Among authors: schilling b. Nat Aging. 2023 Mar;3(3):248-257. doi: 10.1038/s43587-022-00357-y. Epub 2023 Feb 9. Nat Aging. 2023. PMID: 37118425 Free PMC article. Clinical Trial.
Here we report the results of a post hoc analysis of the influence of CR on DNAm measures of aging in blood samples from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, a randomized controlled trial in which n = 220 adults wi …
Here we report the results of a post hoc analysis of the influence of CR on DNAm measures of aging in blood samples from the Comprehensive A …
A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence.
Kang T, Moore EC, Kopania EEK, King CD, Schilling B, Campisi J, Good JM, Brem RB. Kang T, et al. Among authors: schilling b. G3 (Bethesda). 2023 Jul 5;13(7):jkad091. doi: 10.1093/g3journal/jkad091. G3 (Bethesda). 2023. PMID: 37097016 Free PMC article.
In acute irradiation experiments, cells lacking USF2 had compromised DNA damage repair and response. Longer-term senescent cultures without USF2 mounted an exaggerated senescence regulatory program-shutting down cell cycle and DNA repair pathways, and turning up cytokine e …
In acute irradiation experiments, cells lacking USF2 had compromised DNA damage repair and response. Longer-term senescent cultures w …
Effects of a Short-Term Heat Acclimation Protocol in Elite Amateur Boxers.
Stone BL, Ashley JD, Skinner RM, Polanco JP, Walters MT, Schilling BK, Kellawan JM. Stone BL, et al. Among authors: schilling bk. J Strength Cond Res. 2022 Jul 1;36(7):1966-1971. doi: 10.1519/JSC.0000000000004233. Epub 2022 May 2. J Strength Cond Res. 2022. PMID: 35510889
Although heat and humidity negatively affect acute exercise performance, short-term exercise training in hot and humid environments can lead to physiological adaptations that enhance exercise performance in both hot and thermoneutral conditions. In highly trained endurance …
Although heat and humidity negatively affect acute exercise performance, short-term exercise training in hot and humid environments c …
MAPKinase inhibition after failure of immune checkpoint blockade in patients with advanced melanoma - An evaluation of the multicenter prospective skin cancer registry ADOREG.
Kreft S, Glutsch V, Zaremba A, Schummer P, Mohr P, Grimmelmann I, Gutzmer R, Meier F, Pföhler C, Sachse MM, Meiss F, Forschner A, Haferkamp S, Welzel J, Terheyden P, Herbst R, Utikal J, Kaatz M, Weishaupt C, Kreuter A, Debus D, Duecker P, Sindrilaru A, Löffler H, Schley G, Weichenthal M, Schadendorf D, Ugurel S, Gesierich A, Schilling B. Kreft S, et al. Among authors: schilling b. Eur J Cancer. 2022 May;167:32-41. doi: 10.1016/j.ejca.2022.02.023. Epub 2022 Mar 30. Eur J Cancer. 2022. PMID: 35366571 Free article.
CONCLUSIONS: BRAF plus MEK inhibition shows meaningful activity and outcome in patients with advanced melanoma resistant to anti-PD-1-based immunotherapy. Rates of long-term benefit and survival in our study were similar to those reported for treatment-naive patients recei …
CONCLUSIONS: BRAF plus MEK inhibition shows meaningful activity and outcome in patients with advanced melanoma resistant to anti-PD-1-based …
Proteome plasticity in response to persistent environmental change.
Domnauer M, Zheng F, Li L, Zhang Y, Chang CE, Unruh JR, Conkright-Fincham J, McCroskey S, Florens L, Zhang Y, Seidel C, Fong B, Schilling B, Sharma R, Ramanathan A, Si K, Zhou C. Domnauer M, et al. Among authors: schilling b. Mol Cell. 2021 Aug 19;81(16):3294-3309.e12. doi: 10.1016/j.molcel.2021.06.028. Epub 2021 Jul 21. Mol Cell. 2021. PMID: 34293321 Free PMC article.
Acute temperature change activates cellular stress responses, resulting in refolding or removal of damaged proteins. However, how organisms adapt to long-term temperature change remains largely unexplored. Here we report that budding yeast responds to long-term high …
Acute temperature change activates cellular stress responses, resulting in refolding or removal of damaged proteins. However, how organisms …
DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma.
Filipski K, Scherer M, Zeiner KN, Bucher A, Kleemann J, Jurmeister P, Hartung TI, Meissner M, Plate KH, Fenton TR, Walter J, Tierling S, Schilling B, Zeiner PS, Harter PN. Filipski K, et al. Among authors: schilling b. J Immunother Cancer. 2021 Jul;9(7):e002226. doi: 10.1136/jitc-2020-002226. J Immunother Cancer. 2021. PMID: 34281986 Free PMC article.
BACKGROUND: Therapies based on targeting immune checkpoints have revolutionized the treatment of metastatic melanoma in recent years. Still, biomarkers predicting long-term therapy responses are lacking. METHODS: A novel approach of reference-free deconvolution of large-sc …
BACKGROUND: Therapies based on targeting immune checkpoints have revolutionized the treatment of metastatic melanoma in recent years. Still, …
[Endocrine side effects of cancer immunotherapy].
Kroiß M, Schilling B, Deutschbein T. Kroiß M, et al. Among authors: schilling b. Dtsch Med Wochenschr. 2020 Dec;145(24):1736-1741. doi: 10.1055/a-1140-2920. Epub 2020 Nov 30. Dtsch Med Wochenschr. 2020. PMID: 33254246 German.
Therapy consists of immediate intravenous glucocorticoid replacement while therapeutic doses of glucocorticoids are rarely necessary. Oral replacement of all affected hormonal axes is the long-term treatment. Thyroiditis is common also in PD-1/PD-L1 monotherapy. ...
Therapy consists of immediate intravenous glucocorticoid replacement while therapeutic doses of glucocorticoids are rarely necessary. Oral r …
29 results